BGC0000133 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000133 (Amycolatopsis orientalis)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	82,338	abyssomicin C / atrop-abyssomicin C	Polyketide:Modular type I	35%

BGC0000133 - Region 1 - T1PKS

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Location: 1 - 82,338 nt. (total: 82,338 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 82,339
Label		BGC0000133

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000133.1	0.66	Polyketide	quartromicin A1	Amycolatopsis orientalis
BGC0000041.1	0.36	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000719.1	0.30	Saccharide	tobramycin	Streptoalloteichus hindustanus
BGC0001988.1	0.29	Polyketide	neosartorin	Aspergillus novofumigatus IBT 16806
BGC0001257.1	0.29	Polyketide	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001906.1	0.29	Polyketide	naphthalene	Daldinia eschscholzii IFB-TL01
BGC0000057.1	0.29	Polyketide	F9775A, F9775B, orsellinic acid	Aspergillus nidulans FGSC A4
BGC0001265.1	0.29	Polyketide	melanin	Bipolaris oryzae
BGC0000156.1	0.29	Polyketide	TAN-1612, 1-(2,3,5,10-tetrahydroxy-7-methoxy-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl)pentane-2,4-dione, desmethyl TAN-1612	Aspergillus niger
BGC0000107.1	0.28	Polyketide	naphthopyrone	Aspergillus nidulans FGSC A4

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000133.1	0.90	Polyketide	quartromicin A1	Amycolatopsis orientalis
BGC0000041.1	0.69	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000719.1	0.64	Saccharide	tobramycin	Streptoalloteichus hindustanus
BGC0001988.1	0.63	Polyketide	neosartorin	Aspergillus novofumigatus IBT 16806
BGC0001257.1	0.63	Polyketide	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001906.1	0.63	Polyketide	naphthalene	Daldinia eschscholzii IFB-TL01
BGC0000057.1	0.63	Polyketide	F9775A, F9775B, orsellinic acid	Aspergillus nidulans FGSC A4
BGC0001265.1	0.62	Polyketide	melanin	Bipolaris oryzae
BGC0000156.1	0.62	Polyketide	TAN-1612, 1-(2,3,5,10-tetrahydroxy-7-methoxy-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl)pentane-2,4-dione, desmethyl TAN-1612	Aspergillus niger
BGC0000107.1	0.62	Polyketide	naphthopyrone	Aspergillus nidulans FGSC A4

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 3934 - 70896:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - Me-ccmal - Me-ccmal - ccmal) + (Me-ccmal) + (mal)
Non-colinear ordering:: AFI57005.1 + AFI57006.1 + AFI57007.1

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

AFI57005.1

PKS_AT (493..778): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 83.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 205.9
inactive: 116.8
Methoxymalonyl-CoA: 69.0
Methylmalonyl-CoA: 62.7
Propionyl-CoA: 44.9
Isobutyryl-CoA: 34.7
Ethylmalonyl-CoA: 22.8
Acetyl-CoA: 16.9
2-Methylbutyryl-CoA: 15.2
fatty_acid: 12.7
Benzoyl-CoA: 10.5
CHC-CoA: 10.1
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (1471..1758): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 217.4
Ethylmalonyl-CoA: 211.8
Methoxymalonyl-CoA: 175.7
trans-1,2-CPDA: 145.8
2-Methylbutyryl-CoA: 141.1
Propionyl-CoA: 114.1
Malonyl-CoA: 103.1
CHC-CoA: 85.7
Isobutyryl-CoA: 81.4
Benzoyl-CoA: 65.2
Acetyl-CoA: 48.3
fatty_acid: 42.4
3-Methylbutyryl-CoA: 36.5
inactive: 22.9

PKS_AT (3116..3408): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 218.4
Ethylmalonyl-CoA: 206.1
Methoxymalonyl-CoA: 166.7
2-Methylbutyryl-CoA: 149.3
trans-1,2-CPDA: 127.1
Propionyl-CoA: 106.6
Malonyl-CoA: 90.8
CHC-CoA: 90.0
Benzoyl-CoA: 73.8
Isobutyryl-CoA: 67.8
fatty_acid: 33.6
Acetyl-CoA: 32.4
3-Methylbutyryl-CoA: 29.7
inactive: 14.2

PKS_AT (4787..5068): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 217.4
inactive: 108.2
Methoxymalonyl-CoA: 65.7
Methylmalonyl-CoA: 55.2
Propionyl-CoA: 43.6
Benzoyl-CoA: 31.4
Ethylmalonyl-CoA: 29.6
Isobutyryl-CoA: 28.2
2-Methylbutyryl-CoA: 23.4
Acetyl-CoA: 22.6
fatty_acid: 17.4
trans-1,2-CPDA: 16.6
CHC-CoA: 15.1
3-Methylbutyryl-CoA: 0.0

AFI57006.1

PKS_AT (568..867): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 213.6
Ethylmalonyl-CoA: 209.4
Methoxymalonyl-CoA: 176.2
2-Methylbutyryl-CoA: 155.5
trans-1,2-CPDA: 132.8
Propionyl-CoA: 116.3
Malonyl-CoA: 112.9
CHC-CoA: 106.5
Isobutyryl-CoA: 76.9
Benzoyl-CoA: 56.5
Acetyl-CoA: 38.9
3-Methylbutyryl-CoA: 36.7
fatty_acid: 29.9
inactive: 16.4

AFI57007.1

PKS_AT (563..854): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 204.2
inactive: 105.5
Methoxymalonyl-CoA: 62.9
Methylmalonyl-CoA: 48.8
Isobutyryl-CoA: 35.1
Propionyl-CoA: 30.7
Acetyl-CoA: 14.9
Benzoyl-CoA: 11.9
fatty_acid: 10.6
CHC-CoA: 6.8
trans-1,2-CPDA: 6.3
Ethylmalonyl-CoA: 5.2
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0