BGC0000157 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000157 (Streptomyces sp. CK4412)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	70,100	tautomycetin	Polyketide:Modular type I	66%

BGC0000157 - Region 1 - T1PKS

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Location: 1 - 70,100 nt. (total: 70,100 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 70,101
Label		BGC0000157

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000157.1	0.73	Polyketide	tautomycetin	Streptomyces sp. CK4412
BGC0000158.1	0.56	Polyketide	tautomycetin	Streptomyces griseochromogenes
BGC0000019.1	0.27	Polyketide	angolamycin	Streptomyces eurythermus
BGC0000138.1	0.27	Polyketide	rimocidin	Streptomyces diastaticus
BGC0000706.1	0.26	Saccharide	kanamycin	Streptomyces kanamyceticus
BGC0000076.1	0.25	Polyketide	hypothemycin	Hypomyces subiculosus
BGC0000077.1	0.25	Polyketide	hypothemycin	Hypomyces subiculosus
BGC0002063.1	0.22	Polyketide	cryptosporioptide A, cryptosporioptide B, cryptosporioptide C	Cryptosporiopsis sp. 8999
BGC0001245.1	0.21	Polyketide	lasiodiplodin	Lasiodiplodia theobromae
BGC0000886.1	0.21	Other	allylmalonyl-CoA	Streptomyces tsukubensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000157.1	0.90	Polyketide	tautomycetin	Streptomyces sp. CK4412
BGC0000158.1	0.82	Polyketide	tautomycetin	Streptomyces griseochromogenes
BGC0000019.1	0.61	Polyketide	angolamycin	Streptomyces eurythermus
BGC0000138.1	0.61	Polyketide	rimocidin	Streptomyces diastaticus
BGC0000706.1	0.60	Saccharide	kanamycin	Streptomyces kanamyceticus
BGC0000076.1	0.59	Polyketide	hypothemycin	Hypomyces subiculosus
BGC0000077.1	0.59	Polyketide	hypothemycin	Hypomyces subiculosus
BGC0002063.1	0.55	Polyketide	cryptosporioptide A, cryptosporioptide B, cryptosporioptide C	Cryptosporiopsis sp. 8999
BGC0001245.1	0.54	Polyketide	lasiodiplodin	Lasiodiplodia theobromae
BGC0000886.1	0.54	Other	allylmalonyl-CoA	Streptomyces tsukubensis

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 70100:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - Me-ccmal - ohmal - Me-ccmal - ccmal - Me-redmal) + (Me-redmal - redmal - pk - ohmal)
Non-colinear ordering:: ABI94379.1 + ABI94380.1

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ABI94379.1

PKS_AT (645..919): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 70.8%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 210.8
inactive: 96.1
Methoxymalonyl-CoA: 70.4
Methylmalonyl-CoA: 53.1
Propionyl-CoA: 38.9
Isobutyryl-CoA: 31.6
Benzoyl-CoA: 30.1
Acetyl-CoA: 24.8
fatty_acid: 22.0
2-Methylbutyryl-CoA: 16.7
trans-1,2-CPDA: 15.9
Ethylmalonyl-CoA: 12.9
CHC-CoA: 9.9
3-Methylbutyryl-CoA: 0.0

PKS_AT (1622..1904): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 196.2
Ethylmalonyl-CoA: 187.2
Methoxymalonyl-CoA: 160.8
2-Methylbutyryl-CoA: 129.4
Propionyl-CoA: 105.2
trans-1,2-CPDA: 102.6
Malonyl-CoA: 99.9
CHC-CoA: 96.4
Isobutyryl-CoA: 80.3
Benzoyl-CoA: 79.7
Acetyl-CoA: 56.2
inactive: 36.1
3-Methylbutyryl-CoA: 33.5
fatty_acid: 25.8

PKS_AT (3295..3571): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 70.8%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 213.2
inactive: 95.5
Methoxymalonyl-CoA: 70.9
Methylmalonyl-CoA: 53.4
Propionyl-CoA: 43.2
Isobutyryl-CoA: 31.6
Benzoyl-CoA: 28.8
Acetyl-CoA: 25.1
fatty_acid: 21.5
2-Methylbutyryl-CoA: 19.5
Ethylmalonyl-CoA: 14.8
trans-1,2-CPDA: 11.7
CHC-CoA: 9.6
3-Methylbutyryl-CoA: 0.0

PKS_AT (4788..5066): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 195.6
Ethylmalonyl-CoA: 187.5
Methoxymalonyl-CoA: 162.0
2-Methylbutyryl-CoA: 121.3
trans-1,2-CPDA: 116.9
Malonyl-CoA: 110.7
Propionyl-CoA: 108.8
CHC-CoA: 95.8
Benzoyl-CoA: 80.4
Isobutyryl-CoA: 76.6
Acetyl-CoA: 50.0
inactive: 42.1
fatty_acid: 24.7
3-Methylbutyryl-CoA: 24.6

PKS_AT (6414..6690): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 70.8%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 211.0
inactive: 97.1
Methoxymalonyl-CoA: 71.6
Methylmalonyl-CoA: 55.8
Propionyl-CoA: 42.7
Isobutyryl-CoA: 32.8
Benzoyl-CoA: 29.3
Acetyl-CoA: 25.6
fatty_acid: 20.5
2-Methylbutyryl-CoA: 19.4
Ethylmalonyl-CoA: 16.2
trans-1,2-CPDA: 12.1
CHC-CoA: 10.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (8112..8394): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 195.7
Ethylmalonyl-CoA: 185.2
Methoxymalonyl-CoA: 160.5
2-Methylbutyryl-CoA: 128.9
Propionyl-CoA: 105.2
trans-1,2-CPDA: 102.7
Malonyl-CoA: 101.1
CHC-CoA: 96.6
Isobutyryl-CoA: 80.2
Benzoyl-CoA: 78.9
Acetyl-CoA: 55.6
inactive: 35.6
3-Methylbutyryl-CoA: 33.0
fatty_acid: 26.0

ABI94380.1

PKS_AT (626..907): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 198.4
Ethylmalonyl-CoA: 192.8
Methoxymalonyl-CoA: 165.6
2-Methylbutyryl-CoA: 135.3
trans-1,2-CPDA: 121.5
Propionyl-CoA: 111.8
Malonyl-CoA: 102.5
CHC-CoA: 97.5
Isobutyryl-CoA: 77.1
Benzoyl-CoA: 71.9
Acetyl-CoA: 53.3
inactive: 37.3
fatty_acid: 27.1
3-Methylbutyryl-CoA: 20.7

PKS_AT (2631..2908): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 70.8%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 209.8
inactive: 96.2
Methoxymalonyl-CoA: 70.1
Methylmalonyl-CoA: 53.5
Propionyl-CoA: 38.4
Isobutyryl-CoA: 31.6
Benzoyl-CoA: 30.7
Acetyl-CoA: 24.9
fatty_acid: 20.9
2-Methylbutyryl-CoA: 16.1
trans-1,2-CPDA: 16.0
Ethylmalonyl-CoA: 12.6
CHC-CoA: 9.7
3-Methylbutyryl-CoA: 0.0

PKS_AT (4647..4940): pk

ATSignature: Ethylmalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 100.0%; Methylmalonyl-CoA: 83.3%; Methoxymalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 168.4
Ethylmalonyl-CoA: 165.6
Methoxymalonyl-CoA: 140.6
2-Methylbutyryl-CoA: 128.3
Propionyl-CoA: 105.6
trans-1,2-CPDA: 103.5
CHC-CoA: 90.4
Malonyl-CoA: 72.9
Isobutyryl-CoA: 62.8
Benzoyl-CoA: 44.5
fatty_acid: 36.8
Acetyl-CoA: 26.1
3-Methylbutyryl-CoA: 25.8
inactive: 22.5

PKS_AT (6357..6634): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 70.8%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 209.8
inactive: 96.2
Methoxymalonyl-CoA: 70.1
Methylmalonyl-CoA: 53.5
Propionyl-CoA: 38.4
Isobutyryl-CoA: 31.6
Benzoyl-CoA: 30.7
Acetyl-CoA: 24.9
fatty_acid: 20.9
2-Methylbutyryl-CoA: 16.1
trans-1,2-CPDA: 16.0
Ethylmalonyl-CoA: 12.6
CHC-CoA: 9.7
3-Methylbutyryl-CoA: 0.0