BGC0000290 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000290 (Streptomyces toyocaensis)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS,T3PKS	1	69,301	teicoplanin	NRP	55%

BGC0000290 - Region 1 - NRPS,T3PKS

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Location: 1 - 69,301 nt. (total: 69,301 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 69,302
Label		BGC0000290

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000290.1	1.01	NRP	A-47934	Streptomyces toyocaensis
BGC0001249.1	0.65	NRP	dimethylcoprogen	Alternaria alternata
BGC0001831.1	0.64	Polyketide	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0000900.1	0.63	Other	ferrichrome	Aspergillus oryzae
BGC0000348.1	0.62	NRP	ergovaline	Epichloe festucae var. lolii
BGC0001717.1	0.58	Alkaloid	okaramine B	Penicillium simplicissimum
BGC0000351.1	0.57	NRP	exochelin	Mycolicibacterium smegmatis
BGC0001718.1	0.56	NRP	okaramine D	Aspergillus aculeatus ATCC 16872
BGC0001479.1	0.54	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0000889.1	0.54	Other	bagremycin A, bagremycin B	Streptomyces sp. WK-5344

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000290.1	0.89	NRP	A-47934	Streptomyces toyocaensis
BGC0000427.1	0.68	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0000902.1	0.67	Other	flaviolin	Saccharopolyspora erythraea NRRL 2338
BGC0000285.1	0.67	Polyketide, Saccharide	flaviolin rhamnoside, 3,3'-diflaviolin, flaviolin	Saccharopolyspora erythraea
BGC0001310.1	0.67	Terpene	naringenin	Streptomyces clavuligerus ATCC 27064
BGC0000351.1	0.66	NRP	exochelin	Mycolicibacterium smegmatis
BGC0001050.1	0.66	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0000876.1	0.66	Other	neopolyoxin C	Streptomyces tendae
BGC0001249.1	0.66	NRP	dimethylcoprogen	Alternaria alternata
BGC0000457.1	0.66	NRP	vicibactin	Rhizobium etli CFN 42

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 69301:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (hpg - D-tyr) + (D-dhpg) + (D-hpg - D-hpg - bht) + (dhpg)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 0 - 61458:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (hpg - D-tyr) + (D-dhpg) + (D-hpg - D-hpg - bht) + (dhpg)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 32220 - 69301:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (hpg - D-tyr) + (D-dhpg)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

AAM80536.1

Search NORINE for peptide: strict or relaxed

AMP-binding (470..865): dhpg

NRPSPredictor2: dhpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: dhpg, hpg
Single AA prediction:: dhpg

Stachelhaus prediction details:

Stachelhaus sequence:: DAYHGGTLCK
Nearest Stachelhaus code:: dhpg
Stachelhaus code match:: 100% (strong)

AAM80537.1

Search NORINE for peptide: strict or relaxed

AMP-binding (459..854): hpg

NRPSPredictor2: hpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: dhpg, hpg
Single AA prediction:: hpg

Stachelhaus prediction details:

Stachelhaus sequence:: DIFHLGLLCK
Nearest Stachelhaus code:: hpg
Stachelhaus code match:: 100% (strong)

AMP-binding (1955..2345): hpg

NRPSPredictor2: hpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: dhpg, hpg
Single AA prediction:: hpg

Stachelhaus prediction details:

Stachelhaus sequence:: DAFHLGLLCK
Nearest Stachelhaus code:: hpg
Stachelhaus code match:: 100% (strong)

AMP-binding (3467..3854): bht

NRPSPredictor2: bht

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: tyr, bht
Single AA prediction:: bht

Stachelhaus prediction details:

Stachelhaus sequence:: DASTVAGVCK
Nearest Stachelhaus code:: bht
Stachelhaus code match:: 100% (strong)

AAM80538.1

Search NORINE for peptide: strict or relaxed

AMP-binding (467..855): dhpg

NRPSPredictor2: dhpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: dhpg, hpg
Single AA prediction:: dhpg

Stachelhaus prediction details:

Stachelhaus sequence:: DAYNLGTLCK
Nearest Stachelhaus code:: dhpg
Stachelhaus code match:: 100% (strong)

AAM80539.1

Search NORINE for peptide: strict or relaxed

AMP-binding (13..401): hpg

NRPSPredictor2: hpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: dhpg, hpg
Single AA prediction:: hpg

Stachelhaus prediction details:

Stachelhaus sequence:: DAFHLGLLCK
Nearest Stachelhaus code:: hpg
Stachelhaus code match:: 100% (strong)

AMP-binding (1036..1423): tyr

NRPSPredictor2: tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: tyr, bht
Single AA prediction:: tyr

Stachelhaus prediction details:

Stachelhaus sequence:: DASTVAAVCK
Nearest Stachelhaus code:: tyr
Stachelhaus code match:: 100% (strong)