BGC0000377 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000377 (Bacillus sp. NK2003)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS,NRPS-like	1	30,538

BGC0000377 - Region 1 - NRPS,NRPS-like

Download region GenBank file

Download region SVG

Location: 1 - 30,538 nt. (total: 30,538 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 30,539
Label		BGC0000377

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000377.1	1.73	NRP	koranimine	Bacillus sp. NK2003
BGC0000426.1	0.76	NRP	sevadicin	Paenibacillus larvae
BGC0001168.1	0.67	NRP	livipeptin	Streptomyces lividans 1326
BGC0001599.1	0.66	NRP	fragin	Burkholderia cenocepacia H111
BGC0001900.1	0.66	NRP	fragin	Burkholderia cenocepacia H111
BGC0000416.1	0.61	NRP	rhabdopeptide 1, rhabdopeptide 2, rhabdopeptide 3, rhabdopeptide 4	Xenorhabdus nematophila ATCC 19061
BGC0001434.1	0.61	NRP	nematophin	Xenorhabdus budapestensis
BGC0001698.1	0.61	NRP	nevaltophin A, nevaltophin B, nevaltophin C, nevaltophin D	Xenorhabdus budapestensis
BGC0001629.1	0.59	NRP	Jessenipeptin	Pseudomonas sp. QS1027
BGC0000389.1	0.56	NRP	massetolide A	Pseudomonas fluorescens SS101

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000377.1	1.00	NRP	koranimine	Bacillus sp. NK2003
BGC0000426.1	0.70	NRP	sevadicin	Paenibacillus larvae
BGC0001168.1	0.67	NRP	livipeptin	Streptomyces lividans 1326
BGC0001599.1	0.66	NRP	fragin	Burkholderia cenocepacia H111
BGC0001900.1	0.66	NRP	fragin	Burkholderia cenocepacia H111
BGC0001527.1	0.65	Other	basidioferrin	Gelatoporia subvermispora
BGC0000416.1	0.63	NRP	rhabdopeptide 1, rhabdopeptide 2, rhabdopeptide 3, rhabdopeptide 4	Xenorhabdus nematophila ATCC 19061
BGC0001434.1	0.62	NRP	nematophin	Xenorhabdus budapestensis
BGC0001698.1	0.62	NRP	nevaltophin A, nevaltophin B, nevaltophin C, nevaltophin D	Xenorhabdus budapestensis
BGC0001629.1	0.62	NRP	Jessenipeptin	Pseudomonas sp. QS1027

Similar known gene clusters

No matches found.

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 30538:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (thr - D-leu) + (D-X) + (D-tyr) + (val)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 4522 - 30538:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (thr - D-leu) + (D-X) + (D-tyr) + (val)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

korA

Search NORINE for peptide: strict or relaxed

AMP-binding (9..406): thr

NRPSPredictor2: thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: thr
Single AA prediction:: thr

Stachelhaus prediction details:

Stachelhaus sequence:: DFWNIGMVHK
Nearest Stachelhaus code:: thr
Stachelhaus code match:: 100% (strong)

AMP-binding (1070..1461): leu

NRPSPredictor2: leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: leu

Stachelhaus prediction details:

Stachelhaus sequence:: DAWFLGNVVK
Nearest Stachelhaus code:: leu
Stachelhaus code match:: 100% (strong)

korB

Search NORINE for peptide: strict or relaxed

AMP-binding (557..944): X

NRPSPredictor2: val, leu, ile, abu, iva

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAyVfGAVwK
Nearest Stachelhaus code:: phe
Stachelhaus code match:: 70% (weak)

korC

Search NORINE for peptide: strict or relaxed

AMP-binding (1099..1492): tyr

NRPSPredictor2: tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: tyr, bht
Single AA prediction:: tyr

Stachelhaus prediction details:

Stachelhaus sequence:: DsiigAGVCK
Nearest Stachelhaus code:: phe
Stachelhaus code match:: 60% (weak)

korD

Search NORINE for peptide: strict or relaxed

AMP-binding (14..403): val

NRPSPredictor2: val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: val

Stachelhaus prediction details:

Stachelhaus sequence:: DAFfvGGTFK
Nearest Stachelhaus code:: val
Stachelhaus code match:: 80% (moderate)