BGC0001205 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001205 (Penicillium expansum)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS,indole	1	47,244	ergotamine	Terpene	23%

BGC0001205 - Region 1 - T1PKS,indole

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Location: 1 - 47,244 nt. (total: 47,244 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
indole: (indsynth or dmat or indole_PTase)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 47,245
Label		BGC0001205

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001205.1	1.00	Polyketide	communesin A, communesin B, communesin C, communesin D, communesin E, communesin G, communesin H	Penicillium expansum
BGC0001775.1	0.46	Terpene	sespendole	Cordana terrestris
BGC0001241.1	0.42	Terpene	ergotamine	Claviceps fusiformis
BGC0001267.1	0.42	Terpene	lysergic acid, elymoclavine	Claviceps fusiformis
BGC0000823.1	0.39	Alkaloid	rebeccamycin	Lechevalieria aerocolonigenes
BGC0000822.1	0.37	Alkaloid	rebeccamycin	Lechevalieria aerocolonigenes
BGC0001538.1	0.36	NRP, Polyketide	caboxamycin	Streptomyces sp. NTK 937
BGC0000811.1	0.36	Alkaloid	fumigaclavine C	Aspergillus fumigatus Af293
BGC0001068.1	0.35	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0000821.1	0.35	Other, , (, A, m, i, n, o, c, o, u, m, a, r, i, n, )	rebeccamycin	Lechevalieria aerocolonigenes

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001205.1	0.87	Polyketide	communesin A, communesin B, communesin C, communesin D, communesin E, communesin G, communesin H	Penicillium expansum
BGC0001068.1	0.68	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0000046.1	0.65	Polyketide	depudecin	Alternaria brassicicola
BGC0001858.1	0.65	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0000003.1	0.60	Polyketide	AF-toxin	Alternaria alternata
BGC0001538.1	0.58	NRP, Polyketide	caboxamycin	Streptomyces sp. NTK 937
BGC0001892.1	0.58	Polyketide	botcinic acid	Botrytis cinerea B05.10
BGC0001405.1	0.57	Polyketide	chaetoviridin E, 11-epichaetomugilin A	Chaetomium globosum CBS 148.51
BGC0001909.1	0.57	Polyketide	strobilurin	Strobilurus tenacellus
BGC0000823.1	0.56	Alkaloid	rebeccamycin	Lechevalieria aerocolonigenes

Similar known gene clusters

Module view

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 1256 - 47244:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

PEXP_030520

Search NORINE for peptide: strict or relaxed

AMP-binding (39..375): X

NRPSPredictor2: val, leu, ile, abu, iva

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: N/A
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: sfsyiggpak
Nearest Stachelhaus code:: N, A
Stachelhaus code match:: 0% (weak)

PEXP_030540

PKS_AT (548..867): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; Methylmalonyl-CoA: 62.5%; Ethylmalonyl-CoA: 58.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 81.4
Methoxymalonyl-CoA: 80.4
Malonyl-CoA: 59.6
Isobutyryl-CoA: 56.1
Ethylmalonyl-CoA: 52.3
Propionyl-CoA: 35.9
Benzoyl-CoA: 27.8
2-Methylbutyryl-CoA: 26.5
inactive: 22.7
Acetyl-CoA: 16.4
trans-1,2-CPDA: 15.5
fatty_acid: 12.8
3-Methylbutyryl-CoA: 10.7
CHC-CoA: 0.0