BGC0001290 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001290 (Aspergillus nidulans FGSC A4)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS,T1PKS	1	37,424

BGC0001290 - Region 1 - NRPS,T1PKS

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Location: 1 - 37,424 nt. (total: 37,424 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 37,425
Label		BGC0001290

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001290.1	1.18	NRP	emericellamide A, emericellamide B	Aspergillus nidulans FGSC A4
BGC0001068.1	0.54	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0001858.1	0.47	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0000046.1	0.47	Polyketide	depudecin	Alternaria brassicicola
BGC0001124.1	0.42	Polyketide	pyranonigrin E	Aspergillus niger ATCC 1015
BGC0000107.1	0.42	Polyketide	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001252.1	0.42	Polyketide	UNII-YC2Q1O94PT	Alternaria alternata
BGC0000013.1	0.41	Polyketide	alternariol	Aspergillus nidulans FGSC A4
BGC0001258.1	0.41	Polyketide	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0001265.1	0.41	Polyketide	melanin	Bipolaris oryzae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001290.1	0.94	NRP	emericellamide A, emericellamide B	Aspergillus nidulans FGSC A4
BGC0001220.1	0.64	NRP	aculeacin A	Aspergillus japonicus
BGC0001166.1	0.63	NRP	HC-toxin	Alternaria jesenskae
BGC0001261.1	0.62	NRP	AM-toxin	Alternaria alternata
BGC0001135.1	0.62	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001833.1	0.61	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001758.1	0.61	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001240.1	0.61	NRP	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0001068.1	0.61	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0001128.1	0.60	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1

Similar known gene clusters

No matches found.

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 37424:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-pk) + (ala - X - X - pro - pro)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 4637 - 37424:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-pk) + (ala - X - X - pro - pro)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ANIA_02545

Search NORINE for peptide: strict or relaxed

AMP-binding (1002..1394): ala

NRPSPredictor2: ala

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: gly, ala
Single AA prediction:: ala

Stachelhaus prediction details:

Stachelhaus sequence:: diqgvlamqk
Nearest Stachelhaus code:: N, A
Stachelhaus code match:: 0% (weak)

AMP-binding (2535..2930): X

NRPSPredictor2: hydrophilic

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: dasqiggiyk
Nearest Stachelhaus code:: N, A
Stachelhaus code match:: 0% (weak)

AMP-binding (3619..4018): X

NRPSPredictor2: hydrophobic-aliphatic

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: dihfvgaiak
Nearest Stachelhaus code:: N, A
Stachelhaus code match:: 0% (weak)

AMP-binding (4731..5133): pro

NRPSPredictor2: pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: pro, pip
Small clusters prediction:: pro
Single AA prediction:: pro

Stachelhaus prediction details:

Stachelhaus sequence:: dllvvagilk
Nearest Stachelhaus code:: N, A
Stachelhaus code match:: 0% (weak)

AMP-binding (5823..6216): pro

NRPSPredictor2: pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: pro, pip
Small clusters prediction:: pro
Single AA prediction:: pro

Stachelhaus prediction details:

Stachelhaus sequence:: diailvailk
Nearest Stachelhaus code:: N, A
Stachelhaus code match:: 0% (weak)

ANIA_02547

PKS_AT (586..902): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; Methylmalonyl-CoA: 58.3%; inactive: 54.2%

minowa: Methoxymalonyl-CoA

Prediction, score:

Methoxymalonyl-CoA: 71.8
Methylmalonyl-CoA: 65.1
Malonyl-CoA: 50.2
Isobutyryl-CoA: 45.6
Ethylmalonyl-CoA: 34.2
fatty_acid: 26.3
Propionyl-CoA: 22.5
2-Methylbutyryl-CoA: 21.2
3-Methylbutyryl-CoA: 20.9
inactive: 17.9
Benzoyl-CoA: 11.0
trans-1,2-CPDA: 10.2
Acetyl-CoA: 9.0
CHC-CoA: 0.0

ANIA_02549

Search NORINE for peptide: strict or relaxed

AMP-binding (48..465): X

NRPSPredictor2: val, leu, ile, abu, iva

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: glgyvgavvk
Nearest Stachelhaus code:: N, A
Stachelhaus code match:: 0% (weak)