BGC0001635 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001635 (Nonomuraea sp. ATCC 55076)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS,T3PKS	1	49,434	A40926	NRP:Glycopeptide + Saccharide:Hybrid/tailoring	41%

BGC0001635 - Region 1 - NRPS,T3PKS

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Location: 1 - 49,434 nt. (total: 49,434 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 49,435
Label		BGC0001635

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001635.1	1.06	NRP, Polyketide	kistamicin A	Nonomuraea sp. ATCC 55076
BGC0001831.1	0.67	Polyketide	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0000902.1	0.60	Other	flaviolin	Saccharopolyspora erythraea NRRL 2338
BGC0000285.1	0.59	Polyketide, Saccharide	flaviolin rhamnoside, 3,3'-diflaviolin, flaviolin	Saccharopolyspora erythraea
BGC0001399.1	0.52	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0000457.1	0.52	NRP	vicibactin	Rhizobium etli CFN 42
BGC0001075.1	0.51	Terpene, Polyketide	aurachin RE	Rhodococcus erythropolis
BGC0001132.1	0.50	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001085.1	0.49	NRP, Terpene	teleocidin B1	Streptomyces blastmyceticus
BGC0000426.1	0.48	NRP	sevadicin	Paenibacillus larvae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001635.1	0.87	NRP, Polyketide	kistamicin A	Nonomuraea sp. ATCC 55076
BGC0001629.1	0.68	NRP	Jessenipeptin	Pseudomonas sp. QS1027
BGC0001831.1	0.67	Polyketide	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0000902.1	0.66	Other	flaviolin	Saccharopolyspora erythraea NRRL 2338
BGC0000285.1	0.66	Polyketide, Saccharide	flaviolin rhamnoside, 3,3'-diflaviolin, flaviolin	Saccharopolyspora erythraea
BGC0000426.1	0.66	NRP	sevadicin	Paenibacillus larvae
BGC0000457.1	0.66	NRP	vicibactin	Rhizobium etli CFN 42
BGC0000352.1	0.65	NRP	fimsbactin A	Acinetobacter sp. ADP1
BGC0001434.1	0.65	NRP	nematophin	Xenorhabdus budapestensis
BGC0001698.1	0.65	NRP	nevaltophin A, nevaltophin B, nevaltophin C, nevaltophin D	Xenorhabdus budapestensis

Similar known gene clusters

Module view

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 49434:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-X) + (D-dhpg) + (hpg - D-hpg - tyr) + (hpg)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 18928 - 49434:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (hpg - D-hpg - tyr) + (hpg)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

BKM31_54135

Search NORINE for peptide: strict or relaxed

AMP-binding (457..841): X

NRPSPredictor2: phe, trp, phg, tyr, bht

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVGiVGeItK
Nearest Stachelhaus code:: orn
Stachelhaus code match:: 70% (weak)

BKM31_54140

Search NORINE for peptide: strict or relaxed

AMP-binding (448..832): dhpg

NRPSPredictor2: dhpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: dhpg, hpg
Single AA prediction:: dhpg

Stachelhaus prediction details:

Stachelhaus sequence:: DAhqAGTLyK
Nearest Stachelhaus code:: dpg
Stachelhaus code match:: 70% (weak)

BKM31_54145

Search NORINE for peptide: strict or relaxed

AMP-binding (458..842): hpg

NRPSPredictor2: hpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: dhpg, hpg
Single AA prediction:: hpg

Stachelhaus prediction details:

Stachelhaus sequence:: DiYHLGLLCK
Nearest Stachelhaus code:: hpg
Stachelhaus code match:: 90% (moderate)

AMP-binding (1488..1878): hpg

NRPSPredictor2: hpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: dhpg, hpg
Single AA prediction:: hpg

Stachelhaus prediction details:

Stachelhaus sequence:: DiYHLGmLCK
Nearest Stachelhaus code:: hpg
Stachelhaus code match:: 80% (moderate)

AMP-binding (2992..3376): tyr

NRPSPredictor2: tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: tyr, bht
Single AA prediction:: tyr

Stachelhaus prediction details:

Stachelhaus sequence:: DASTVAAVCK
Nearest Stachelhaus code:: tyr
Stachelhaus code match:: 100% (strong)

BKM31_54150

Search NORINE for peptide: strict or relaxed

AMP-binding (451..848): hpg

NRPSPredictor2: hpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: dhpg, hpg
Single AA prediction:: hpg

Stachelhaus prediction details:

Stachelhaus sequence:: DAyHLGLLCK
Nearest Stachelhaus code:: hpg
Stachelhaus code match:: 90% (moderate)