BGC0000056 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000056 (Actinomadura verrucosospora)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	6,689	High	esperamicin	PKS

BGC0000056 - Region 1 - T1PKS

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Location: 1 - 6,689 nt. (total: 6,689 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 6,690
Label		BGC0000056

Tailoring functions

Ligases: synthase

espE: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000056.3	1.00	PKS	esperamicin	Actinomadura verrucosospora
BGC0001244.3	0.59	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001276.3	0.59	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.3	0.59	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0002171.2	0.45	NRPS, PKS	pyrophen, campyrone B	Aspergillus niger ATCC 1015
BGC0002275.2	0.45	NRPS, PKS	pyrophen, campyrone B	Aspergillus niger CBS 101883
BGC0002387.2	0.41	PKS	yangpumicin A	Micromonospora yangpuensis
BGC0002545.3	0.38	PKS	sungeidine C, sungeidine B, sungeidine D, sungeidine H, sungeidine A, sungeidine E, sungeidine F, sungeidine G	Micromonospora sp.
BGC0000979.3	0.37	NRPS, PKS	cylindrospermopsin	Aphanizomenon sp. 10E9
BGC0000980.3	0.37	NRPS, PKS	cylindrospermopsin	Aphanizomenon sp. 22D11

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000056.3	1.00	PKS	esperamicin	Actinomadura verrucosospora
BGC0001244.3	0.59	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001276.3	0.59	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.3	0.59	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0002171.2	0.45	NRPS, PKS	pyrophen, campyrone B	Aspergillus niger ATCC 1015
BGC0002275.2	0.45	NRPS, PKS	pyrophen, campyrone B	Aspergillus niger CBS 101883
BGC0002387.2	0.41	PKS	yangpumicin A	Micromonospora yangpuensis
BGC0002545.3	0.38	PKS	sungeidine C, sungeidine B, sungeidine D, sungeidine H, sungeidine A, sungeidine E, sungeidine F, sungeidine G	Micromonospora sp.
BGC0000979.3	0.37	NRPS, PKS	cylindrospermopsin	Aphanizomenon sp. 10E9
BGC0000980.3	0.37	NRPS, PKS	cylindrospermopsin	Aphanizomenon sp. 22D11

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

NRPS/PKS substrate predictions

espE: mal

PKS_AT (620..843): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; inactive: 62.5%; Propionyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 86.7
Methoxymalonyl-CoA: 65.8
Methylmalonyl-CoA: 62.4
Ethylmalonyl-CoA: 39.0
inactive: 38.6
Propionyl-CoA: 37.0
Isobutyryl-CoA: 36.1
fatty_acid: 35.0
trans-1,2-CPDA: 20.4
CHC-CoA: 20.3
2-Methylbutyryl-CoA: 14.8
Benzoyl-CoA: 13.1
Acetyl-CoA: 2.1
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor