BGC0000067 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000067 (Streptomyces hygroscopicus subsp. duamyceticus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS,NRPS-like	1	75,920	candicidin	Polyketide	23%

BGC0000067 - Region 1 - NRPS-like,T1PKS

Download region GenBank file

Download region SVG

Location: 1 - 75,920 nt. (total: 75,920 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 75,921
Label		BGC0000067

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000067.1	1.23	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000041.1	0.71	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001164.1	0.58	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000066.1	0.55	Polyketide	geldanamycin	Streptomyces hygroscopicus
BGC0001162.1	0.47	Polyketide	1-heptadecene	Moorea producens JHB
BGC0000143.1	0.47	Polyketide	salinomycin	Streptomyces albus
BGC0001215.1	0.43	NRP	conglobatin	Streptomyces conglobatus
BGC0001235.1	0.43	NRP, Polyketide	antalid	Polyangium spumosum
BGC0000074.1	0.42	Polyketide	herbimycin A	Streptomyces hygroscopicus
BGC0001012.1	0.42	NRP, Polyketide	meridamycin	Streptomyces violaceusniger

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000067.1	0.89	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000041.1	0.68	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000066.1	0.64	Polyketide	geldanamycin	Streptomyces hygroscopicus
BGC0001164.1	0.63	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001162.1	0.57	Polyketide	1-heptadecene	Moorea producens JHB
BGC0000090.1	0.55	Polyketide	macbecin, macbecin II	Actinosynnema pretiosum subsp. pretiosum
BGC0001235.1	0.54	NRP, Polyketide	antalid	Polyangium spumosum
BGC0000074.1	0.54	Polyketide	herbimycin A	Streptomyces hygroscopicus
BGC0001012.1	0.54	NRP, Polyketide	meridamycin	Streptomyces violaceusniger
BGC0000353.1	0.53	NRP	tacrolimus	Streptomyces sp. MA6548

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 75920:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-redmal - redmxmal - Me-ohmal) + (redmal - Me-ccmal) + (Me-ccmal - ohmxmal)
Non-colinear ordering:: ABB86408.1 + ABB86410.1 + ABB86409.1

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ABB86408.1

CAL_domain (34..442): pk

minowa: AHBA

Prediction, score:

AHBA: 538.5
shikimic_acid: 267.8
Acetyl-CoA: 12.5
fatty_acid: 0.0
NH2: 0.0

PKS_AT (1657..1954): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 91.7%; Methoxymalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 204.6
Ethylmalonyl-CoA: 188.2
Methoxymalonyl-CoA: 171.6
2-Methylbutyryl-CoA: 124.0
Propionyl-CoA: 109.7
Malonyl-CoA: 102.6
trans-1,2-CPDA: 96.8
CHC-CoA: 73.8
Isobutyryl-CoA: 69.7
Benzoyl-CoA: 58.4
Acetyl-CoA: 36.8
3-Methylbutyryl-CoA: 36.6
fatty_acid: 25.1
inactive: 22.9

PKS_AT (3727..4027): mxmal

ATSignature: Methoxymalonyl-CoA

Top 3 matches:: Methoxymalonyl-CoA: 100.0%; Ethylmalonyl-CoA: 91.7%; Methylmalonyl-CoA: 91.7%

minowa: Methoxymalonyl-CoA

Prediction, score:

Methoxymalonyl-CoA: 196.5
Methylmalonyl-CoA: 186.9
Ethylmalonyl-CoA: 180.8
2-Methylbutyryl-CoA: 134.0
trans-1,2-CPDA: 111.3
Propionyl-CoA: 96.3
Malonyl-CoA: 91.4
CHC-CoA: 87.9
Isobutyryl-CoA: 61.8
Benzoyl-CoA: 52.2
Acetyl-CoA: 42.1
3-Methylbutyryl-CoA: 37.9
inactive: 27.9
fatty_acid: 17.2

PKS_AT (5794..6093): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 91.7%; Methoxymalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 206.8
Ethylmalonyl-CoA: 187.4
Methoxymalonyl-CoA: 170.4
2-Methylbutyryl-CoA: 125.5
Propionyl-CoA: 106.0
Malonyl-CoA: 100.8
trans-1,2-CPDA: 94.6
CHC-CoA: 79.2
Isobutyryl-CoA: 67.5
Benzoyl-CoA: 61.2
Acetyl-CoA: 37.0
3-Methylbutyryl-CoA: 36.4
inactive: 24.0
fatty_acid: 23.4

ABB86409.1

PKS_AT (574..871): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 91.7%; Methoxymalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 202.5
Ethylmalonyl-CoA: 186.6
Methoxymalonyl-CoA: 169.2
2-Methylbutyryl-CoA: 123.1
Propionyl-CoA: 108.6
Malonyl-CoA: 100.1
trans-1,2-CPDA: 96.1
CHC-CoA: 72.7
Isobutyryl-CoA: 69.0
Benzoyl-CoA: 58.0
3-Methylbutyryl-CoA: 36.9
Acetyl-CoA: 34.3
fatty_acid: 25.3
inactive: 23.5

PKS_AT (2350..2650): mxmal

ATSignature: Methoxymalonyl-CoA

Top 3 matches:: Methoxymalonyl-CoA: 100.0%; Ethylmalonyl-CoA: 91.7%; Methylmalonyl-CoA: 91.7%

minowa: Methoxymalonyl-CoA

Prediction, score:

Methoxymalonyl-CoA: 198.1
Methylmalonyl-CoA: 189.5
Ethylmalonyl-CoA: 184.4
2-Methylbutyryl-CoA: 134.6
trans-1,2-CPDA: 110.3
Propionyl-CoA: 96.8
Malonyl-CoA: 94.7
CHC-CoA: 90.0
Isobutyryl-CoA: 63.6
Benzoyl-CoA: 54.2
Acetyl-CoA: 44.2
3-Methylbutyryl-CoA: 37.9
inactive: 27.4
fatty_acid: 17.3

ABB86410.1

PKS_AT (583..885): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 231.5
inactive: 122.6
Methoxymalonyl-CoA: 70.3
Methylmalonyl-CoA: 62.7
Propionyl-CoA: 40.8
Isobutyryl-CoA: 32.2
Benzoyl-CoA: 29.7
Ethylmalonyl-CoA: 21.5
Acetyl-CoA: 18.5
trans-1,2-CPDA: 14.6
CHC-CoA: 13.1
fatty_acid: 10.8
2-Methylbutyryl-CoA: 10.5
3-Methylbutyryl-CoA: 0.0

PKS_AT (2663..2962): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 91.7%; Methoxymalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 205.5
Ethylmalonyl-CoA: 189.0
Methoxymalonyl-CoA: 170.4
2-Methylbutyryl-CoA: 120.6
Propionyl-CoA: 106.5
Malonyl-CoA: 100.8
trans-1,2-CPDA: 95.7
CHC-CoA: 74.9
Isobutyryl-CoA: 67.2
Benzoyl-CoA: 62.8
Acetyl-CoA: 43.3
3-Methylbutyryl-CoA: 33.7
fatty_acid: 24.0
inactive: 18.7