BGC0000124 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000124 (Streptomyces piomogenus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	49,420	piericidin A1	Polyketide	100%

BGC0000124 - Region 1 - T1PKS

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Location: 1 - 49,420 nt. (total: 49,420 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 49,421
Label		BGC0000124

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000124.1	0.85	Polyketide	piericidin A1	Streptomyces piomogenus
BGC0001742.1	0.50	Polyketide	piericidin A1	Candidatus Streptomyces philanthi bv. triangulum
BGC0000041.1	0.44	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001169.1	0.41	Polyketide	piericidin A1	Streptomyces sp. SCSIO 03032
BGC0001257.1	0.29	Polyketide	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001164.1	0.29	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001906.1	0.29	Polyketide	naphthalene	Daldinia eschscholzii IFB-TL01
BGC0000156.1	0.29	Polyketide	TAN-1612, 1-(2,3,5,10-tetrahydroxy-7-methoxy-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl)pentane-2,4-dione, desmethyl TAN-1612	Aspergillus niger
BGC0001265.1	0.29	Polyketide	melanin	Bipolaris oryzae
BGC0000057.1	0.29	Polyketide	F9775A, F9775B, orsellinic acid	Aspergillus nidulans FGSC A4

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000124.1	0.95	Polyketide	piericidin A1	Streptomyces piomogenus
BGC0001742.1	0.78	Polyketide	piericidin A1	Candidatus Streptomyces philanthi bv. triangulum
BGC0000041.1	0.75	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001169.1	0.73	Polyketide	piericidin A1	Streptomyces sp. SCSIO 03032
BGC0001257.1	0.63	Polyketide	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001164.1	0.63	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001906.1	0.62	Polyketide	naphthalene	Daldinia eschscholzii IFB-TL01
BGC0000156.1	0.62	Polyketide	TAN-1612, 1-(2,3,5,10-tetrahydroxy-7-methoxy-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl)pentane-2,4-dione, desmethyl TAN-1612	Aspergillus niger
BGC0001265.1	0.62	Polyketide	melanin	Bipolaris oryzae
BGC0000057.1	0.62	Polyketide	F9775A, F9775B, orsellinic acid	Aspergillus nidulans FGSC A4

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 49420:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-mal - Me-ccmal) + (Me-ohmal - Me-ccmal) + (ccmal) + (Me-redmal) + (Me-mal - mal)
Non-colinear ordering:: AEZ54374.1 + AEZ54375.1 + AEZ54378.1 + AEZ54377.1 + AEZ54379.1

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

AEZ54374.1

PKS_AT (320..624): mmal

ATSignature: Isobutyryl-CoA, 2-Methylbutyryl-CoA

Top 3 matches:: Isobutyryl-CoA: 75.0%; 2-Methylbutyryl-CoA: 75.0%; Methylmalonyl-CoA: 66.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 145.2
Ethylmalonyl-CoA: 140.4
Methoxymalonyl-CoA: 125.0
2-Methylbutyryl-CoA: 123.7
Propionyl-CoA: 108.5
trans-1,2-CPDA: 98.0
CHC-CoA: 89.5
Malonyl-CoA: 52.5
Isobutyryl-CoA: 52.2
3-Methylbutyryl-CoA: 36.4
Benzoyl-CoA: 32.5
Acetyl-CoA: 24.1
fatty_acid: 21.8
inactive: 0.0

PKS_AT (1310..1604): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 222.9
Ethylmalonyl-CoA: 221.4
Methoxymalonyl-CoA: 168.8
2-Methylbutyryl-CoA: 155.4
trans-1,2-CPDA: 148.8
Propionyl-CoA: 116.6
Malonyl-CoA: 109.0
CHC-CoA: 104.1
Isobutyryl-CoA: 84.1
Benzoyl-CoA: 65.3
Acetyl-CoA: 49.8
3-Methylbutyryl-CoA: 30.7
fatty_acid: 30.1
inactive: 21.6

AEZ54375.1

PKS_AT (561..853): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 222.8
Ethylmalonyl-CoA: 221.7
Methoxymalonyl-CoA: 173.3
2-Methylbutyryl-CoA: 155.7
trans-1,2-CPDA: 147.8
Propionyl-CoA: 116.8
CHC-CoA: 111.8
Malonyl-CoA: 107.3
Isobutyryl-CoA: 83.1
Benzoyl-CoA: 66.5
Acetyl-CoA: 54.5
fatty_acid: 36.1
3-Methylbutyryl-CoA: 31.8
inactive: 22.0

PKS_AT (2099..2391): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 221.1
Ethylmalonyl-CoA: 219.2
Methoxymalonyl-CoA: 171.9
2-Methylbutyryl-CoA: 155.2
trans-1,2-CPDA: 150.1
Propionyl-CoA: 120.6
Malonyl-CoA: 107.6
CHC-CoA: 106.2
Isobutyryl-CoA: 85.8
Benzoyl-CoA: 67.9
Acetyl-CoA: 51.6
3-Methylbutyryl-CoA: 33.7
fatty_acid: 31.4
inactive: 18.8

AEZ54377.1

PKS_AT (539..833): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 220.1
Ethylmalonyl-CoA: 215.6
Methoxymalonyl-CoA: 169.9
2-Methylbutyryl-CoA: 151.9
trans-1,2-CPDA: 148.0
Propionyl-CoA: 120.3
CHC-CoA: 102.6
Malonyl-CoA: 102.1
Isobutyryl-CoA: 86.1
Benzoyl-CoA: 66.5
Acetyl-CoA: 49.4
3-Methylbutyryl-CoA: 32.2
fatty_acid: 29.4
inactive: 18.4

AEZ54378.1

PKS_AT (573..872): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 223.5
inactive: 116.1
Methoxymalonyl-CoA: 58.6
Methylmalonyl-CoA: 56.7
Propionyl-CoA: 39.8
Isobutyryl-CoA: 37.4
Benzoyl-CoA: 27.4
2-Methylbutyryl-CoA: 23.8
Ethylmalonyl-CoA: 18.9
fatty_acid: 17.1
Acetyl-CoA: 16.2
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0
CHC-CoA: -0.2

AEZ54379.1

PKS_AT (618..910): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 223.5
Ethylmalonyl-CoA: 222.1
Methoxymalonyl-CoA: 173.8
2-Methylbutyryl-CoA: 157.4
trans-1,2-CPDA: 146.9
Propionyl-CoA: 117.9
CHC-CoA: 109.2
Malonyl-CoA: 107.1
Isobutyryl-CoA: 83.4
Benzoyl-CoA: 67.0
Acetyl-CoA: 54.2
fatty_acid: 36.1
3-Methylbutyryl-CoA: 31.5
inactive: 22.0

PKS_AT (1650..1953): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 83.3%; inactive: 66.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 179.3
inactive: 79.2
Methoxymalonyl-CoA: 42.9
Methylmalonyl-CoA: 40.0
Isobutyryl-CoA: 21.4
Propionyl-CoA: 20.6
Acetyl-CoA: 13.7
Ethylmalonyl-CoA: 12.0
fatty_acid: 11.1
trans-1,2-CPDA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0