BGC0000167 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000167 (Streptomyces halstedii)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	64,492	sceliphrolactam	Polyketide	52%

BGC0000167 - Region 1 - T1PKS

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Location: 1 - 64,492 nt. (total: 64,492 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 64,493
Label		BGC0000167

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000167.1	0.75	Polyketide	vicenistatin	Streptomyces halstedii
BGC0000041.1	0.42	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001273.1	0.30	Polyketide	asperlactone	Aspergillus ochraceus
BGC0000068.1	0.30	Polyketide	geldanamycin	Streptomyces hygroscopicus
BGC0001276.1	0.30	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.1	0.30	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001050.1	0.29	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0001244.1	0.29	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001062.1	0.28	Polyketide	TLN-05220	Micromonospora echinospora subsp. challisensis
BGC0000465.1	0.28	NRP	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000167.1	0.91	Polyketide	vicenistatin	Streptomyces halstedii
BGC0000041.1	0.74	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001273.1	0.64	Polyketide	asperlactone	Aspergillus ochraceus
BGC0000068.1	0.64	Polyketide	geldanamycin	Streptomyces hygroscopicus
BGC0001276.1	0.63	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.1	0.63	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001050.1	0.63	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0001244.1	0.62	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001062.1	0.62	Polyketide	TLN-05220	Micromonospora echinospora subsp. challisensis
BGC0000465.1	0.61	NRP	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 64492:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (redmal - ccmal - Me-ccmal) + (Me-redmal) + (ccmal - Me-ohmal) + (ccmal - ccmal)
Non-colinear ordering:: vinP1 + vinP2 + vinP3 + vinP4

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

vinP2

PKS_AT (594..906): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 193.7
Ethylmalonyl-CoA: 169.7
Methoxymalonyl-CoA: 138.0
2-Methylbutyryl-CoA: 108.8
trans-1,2-CPDA: 102.0
Malonyl-CoA: 79.7
Propionyl-CoA: 75.0
CHC-CoA: 68.1
Benzoyl-CoA: 61.0
Isobutyryl-CoA: 57.1
Acetyl-CoA: 40.8
inactive: 32.0
3-Methylbutyryl-CoA: 25.1
fatty_acid: 20.9

vinP3

PKS_AT (565..861): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 207.2
inactive: 104.5
Methoxymalonyl-CoA: 46.8
Methylmalonyl-CoA: 46.5
Propionyl-CoA: 26.4
Acetyl-CoA: 20.9
Isobutyryl-CoA: 16.5
Benzoyl-CoA: 15.5
CHC-CoA: 10.7
2-Methylbutyryl-CoA: 8.8
fatty_acid: 8.5
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0
Ethylmalonyl-CoA: -1.0

PKS_AT (2274..2582): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 195.6
Ethylmalonyl-CoA: 173.2
Methoxymalonyl-CoA: 139.6
2-Methylbutyryl-CoA: 111.8
trans-1,2-CPDA: 101.3
Malonyl-CoA: 83.5
Propionyl-CoA: 76.3
CHC-CoA: 70.1
Benzoyl-CoA: 63.5
Isobutyryl-CoA: 61.2
Acetyl-CoA: 43.2
inactive: 34.4
3-Methylbutyryl-CoA: 26.8
fatty_acid: 20.9

vinP4

PKS_AT (569..866): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 211.4
inactive: 107.1
Methoxymalonyl-CoA: 49.1
Methylmalonyl-CoA: 46.8
Propionyl-CoA: 27.0
Acetyl-CoA: 20.9
Isobutyryl-CoA: 16.2
Benzoyl-CoA: 15.5
CHC-CoA: 13.0
Ethylmalonyl-CoA: 12.5
fatty_acid: 8.5
2-Methylbutyryl-CoA: 8.2
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2295..2591): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 208.3
inactive: 105.7
Methoxymalonyl-CoA: 48.6
Methylmalonyl-CoA: 47.5
Propionyl-CoA: 27.3
Acetyl-CoA: 20.3
CHC-CoA: 17.0
Isobutyryl-CoA: 15.8
Ethylmalonyl-CoA: 15.7
Benzoyl-CoA: 15.3
fatty_acid: 8.7
2-Methylbutyryl-CoA: 7.4
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

vinK

PKS_AT (40..301): pk

ATSignature: (unknown)

No matches above 50%

minowa: trans-1,2-CPDA

Prediction, score:

trans-1,2-CPDA: 0.0
inactive: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Methylmalonyl-CoA: 0.0
Methoxymalonyl-CoA: 0.0
Malonyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

vinM

Search NORINE for peptide: strict or relaxed

AMP-binding (15..428): X

NRPSPredictor2: val, leu, ile, abu, iva

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DcFFFalVtK
Nearest Stachelhaus code:: ile
Stachelhaus code match:: 60% (weak)

vinN

Search NORINE for peptide: strict or relaxed

AMP-binding (5..386): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: pro, pip
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DfYptSMriK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 50% (weak)

vinP1

PKS_AT (668..968): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 204.6
inactive: 104.5
Methoxymalonyl-CoA: 48.0
Methylmalonyl-CoA: 43.6
Propionyl-CoA: 26.8
Benzoyl-CoA: 17.1
CHC-CoA: 16.1
Ethylmalonyl-CoA: 13.4
Isobutyryl-CoA: 13.3
trans-1,2-CPDA: 11.6
Acetyl-CoA: 11.2
2-Methylbutyryl-CoA: 9.1
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2749..3042): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 201.9
inactive: 97.9
Methoxymalonyl-CoA: 45.2
Methylmalonyl-CoA: 44.4
Propionyl-CoA: 26.6
Benzoyl-CoA: 18.1
Acetyl-CoA: 15.2
CHC-CoA: 14.7
Ethylmalonyl-CoA: 14.5
Isobutyryl-CoA: 11.8
2-Methylbutyryl-CoA: 8.8
fatty_acid: 8.7
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (4500..4812): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 195.6
Ethylmalonyl-CoA: 173.2
Methoxymalonyl-CoA: 139.6
2-Methylbutyryl-CoA: 111.8
trans-1,2-CPDA: 101.3
Malonyl-CoA: 83.5
Propionyl-CoA: 76.3
CHC-CoA: 70.1
Benzoyl-CoA: 63.5
Isobutyryl-CoA: 61.2
Acetyl-CoA: 43.2
inactive: 34.4
3-Methylbutyryl-CoA: 26.8
fatty_acid: 20.9