BGC0000270 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000270 (Streptomyces antibioticus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T2PKS,aminocoumarin	1	39,428	simocyclinone D8	Saccharide + Polyketide:Modular type I + Polyketide:Type II + Other:Aminocoumarin	60%

BGC0000270 - Region 1 - T2PKS,aminocoumarin

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Location: 1 - 39,428 nt. (total: 39,428 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)
aminocoumarin: (novK or novJ or novI or novH or SpcDK_cou)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 39,429
Label		BGC0000270

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000835.1	1.34	Polyketide	simocyclinone	Streptomyces antibioticus
BGC0000270.1	1.11	Polyketide	simocyclinone D8	Streptomyces antibioticus
BGC0000231.1	0.78	Polyketide	griseusin	Streptomyces griseus
BGC0000234.1	0.61	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001723.1	0.61	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0001072.1	0.59	Polyketide, Saccharide, Other, , (, A, m, i, n, o, c, o, u, m, a, r, i, n, )	simocyclinone D8	Streptomyces antibioticus
BGC0001444.1	0.57	Other	caboxamycin	Streptomyces sp. NTK 937
BGC0000228.1	0.54	Polyketide	granaticin	Streptomyces violaceoruber
BGC0000888.1	0.54	Other	bacilysin	Bacillus sp. CS93
BGC0000457.1	0.53	NRP	vicibactin	Rhizobium etli CFN 42

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000270.1	0.87	Polyketide	simocyclinone D8	Streptomyces antibioticus
BGC0000835.1	0.87	Polyketide	simocyclinone	Streptomyces antibioticus
BGC0000231.1	0.83	Polyketide	griseusin	Streptomyces griseus
BGC0000248.1	0.75	Polyketide	naphtocyclinone	Streptomyces arenae
BGC0000234.1	0.73	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001723.1	0.72	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0001072.1	0.65	Polyketide, Saccharide, Other, , (, A, m, i, n, o, c, o, u, m, a, r, i, n, )	simocyclinone D8	Streptomyces antibioticus
BGC0000228.1	0.65	Polyketide	granaticin	Streptomyces violaceoruber
BGC0001444.1	0.64	Other	caboxamycin	Streptomyces sp. NTK 937
BGC0000272.1	0.62	Polyketide	spore pigment	Streptomyces collinus

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Type II PKS

Predicted core structure(s)

For candidate cluster 1, location 0 - 36379:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (tyr)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

simL

Search NORINE for peptide: strict or relaxed

AMP-binding (15..415): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: snAafTViIK
Nearest Stachelhaus code:: pro
Stachelhaus code match:: 50% (weak)

simH

Search NORINE for peptide: strict or relaxed

AMP-binding (413..808): tyr

NRPSPredictor2: tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: tyr, bht
Single AA prediction:: tyr

Stachelhaus prediction details:

Stachelhaus sequence:: DAtvVAAVCK
Nearest Stachelhaus code:: phe
Stachelhaus code match:: 80% (moderate)

AAL15617.1

Search NORINE for peptide: strict or relaxed

AMP-binding (1..176): X

NRPSPredictor2: hydrophobic-aliphatic

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DLLp-----K
Nearest Stachelhaus code:: ala
Stachelhaus code match:: 40% (weak)

Type II PKS gene cluster prediction details

Cluster section:: 0 to 36379
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 714.3; E-value: 8.4e-218)
Product class(es):: angucycline
anthracycline
aureolic acid
tetracycline
Product molecular weight(s):: acetyl-CoA_8: 391.43 Da
acetyl-CoA_9: 433.47 Da

sim3: CLF 8|9 (Score: 714.3; E-value: 8.4e-218)
sim4: ACP (Score: 132.1; E-value: 1.3e-41)
sim5: KR C9 (Score: 487.6; E-value: 1.9e-149)
sim6: CYC C7-C12 (Score: 499.6; E-value: 6e-153)
sim7: OXY (Score: 589.4; E-value: 1.3e-179)
sim8: KR C15 (Score: 487.4; E-value: 2e-149)
sim9: KR (Score: 42.0; E-value: 2e-13)
simJ1: KR (Score: 210.4; E-value: 8.5e-65)
simJ2: KR (Score: 206.4; E-value: 1.4e-63)
simK: KR (Score: 83.2; E-value: 5.5e-26)