BGC0000322 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000322 (Amycolatopsis orientalis)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	34,244	avoparcin	NRP:Glycopeptide	24%

BGC0000322 - Region 1 - NRPS

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Location: 1 - 34,244 nt. (total: 34,244 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 34,245
Label		BGC0000322

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000351.1	0.38	NRP	exochelin	Mycolicibacterium smegmatis
BGC0000427.1	0.35	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0001249.1	0.32	NRP	dimethylcoprogen	Alternaria alternata
BGC0001261.1	0.31	NRP	AM-toxin	Alternaria alternata
BGC0000348.1	0.31	NRP	ergovaline	Epichloe festucae var. lolii
BGC0001132.1	0.31	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001717.1	0.30	Alkaloid	okaramine B	Penicillium simplicissimum
BGC0001629.1	0.30	NRP	Jessenipeptin	Pseudomonas sp. QS1027
BGC0000420.1	0.29	NRP	histidyltryptophanyldiketopiperazine, dehydrohistidyltryptophanyldiketopiperazine, roquefortine D, roquefortine C, glandicoline A, glandicoline B, meleagrine	Penicillium rubens Wisconsin 54-1255
BGC0002071.1	0.29	NRP	Virginiafactin	Pseudomonas sp. QS1027

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000351.1	0.70	NRP	exochelin	Mycolicibacterium smegmatis
BGC0000427.1	0.68	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0001249.1	0.65	NRP	dimethylcoprogen	Alternaria alternata
BGC0001261.1	0.64	NRP	AM-toxin	Alternaria alternata
BGC0000348.1	0.64	NRP	ergovaline	Epichloe festucae var. lolii
BGC0001132.1	0.64	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001717.1	0.64	Alkaloid	okaramine B	Penicillium simplicissimum
BGC0001629.1	0.63	NRP	Jessenipeptin	Pseudomonas sp. QS1027
BGC0000420.1	0.63	NRP	histidyltryptophanyldiketopiperazine, dehydrohistidyltryptophanyldiketopiperazine, roquefortine D, roquefortine C, glandicoline A, glandicoline B, meleagrine	Penicillium rubens Wisconsin 54-1255
BGC0002071.1	0.63	NRP	Virginiafactin	Pseudomonas sp. QS1027

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 34244:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (leu - D-bht - asn) + (D-hpg - D-hpg - bht) + (dhpg)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

CAA11794.1

Search NORINE for peptide: strict or relaxed

AMP-binding (16..403): leu

NRPSPredictor2: leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAFYLGMMCK
Nearest Stachelhaus code:: leu
Stachelhaus code match:: 100% (strong)

AMP-binding (1038..1424): bht

NRPSPredictor2: bht

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: tyr, bht
Single AA prediction:: bht

Stachelhaus prediction details:

Stachelhaus sequence:: DTSKVAAICK
Nearest Stachelhaus code:: bht
Stachelhaus code match:: 100% (strong)

AMP-binding (2545..2949): asn

NRPSPredictor2: asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: asp, asn
Single AA prediction:: asn

Stachelhaus prediction details:

Stachelhaus sequence:: DLTKLGEVGK
Nearest Stachelhaus code:: asn
Stachelhaus code match:: 100% (strong)

CAA11795.1

Search NORINE for peptide: strict or relaxed

AMP-binding (460..855): hpg

NRPSPredictor2: hpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: dhpg, hpg
Single AA prediction:: hpg

Stachelhaus prediction details:

Stachelhaus sequence:: DIFHLGLLCK
Nearest Stachelhaus code:: hpg
Stachelhaus code match:: 100% (strong)

AMP-binding (1960..2352): hpg

NRPSPredictor2: hpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: dhpg, hpg
Single AA prediction:: hpg

Stachelhaus prediction details:

Stachelhaus sequence:: DAVHLGLLCK
Nearest Stachelhaus code:: hpg
Stachelhaus code match:: 100% (strong)

AMP-binding (3476..3863): bht

NRPSPredictor2: bht

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: tyr, bht
Single AA prediction:: bht

Stachelhaus prediction details:

Stachelhaus sequence:: DASTLGAICK
Nearest Stachelhaus code:: bht
Stachelhaus code match:: 100% (strong)

CAA11796.1

Search NORINE for peptide: strict or relaxed

AMP-binding (470..865): dhpg

NRPSPredictor2: dhpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: dhpg, hpg
Single AA prediction:: dhpg

Stachelhaus prediction details:

Stachelhaus sequence:: DPYHeGTLCK
Nearest Stachelhaus code:: dhpg
Stachelhaus code match:: 90% (moderate)