BGC0000382 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000382 (Streptomyces toxytricini)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS-like	1	19,400	saframycin A / saframycin B	NRP	4%

BGC0000382 - Region 1 - NRPS-like

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Location: 1 - 19,400 nt. (total: 19,400 nt) Show pHMM detection rules used

Region on contig edge.

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 19,401
Label		BGC0000382

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000382.1	1.00	NRP	lipstatin	Streptomyces toxytricini
BGC0001458.1	0.28	Other, , (, A, m, i, n, o, c, o, u, m, a, r, i, n, )	salinipostin G	Salinispora tropica CNB-440
BGC0000871.1	0.28	Other, , (, N, u, c, l, e, o, s, i, d, e, )	VEPE, AEPE, TG-1	Myxococcus xanthus DK 1622
BGC0001168.1	0.20	NRP	livipeptin	Streptomyces lividans 1326
BGC0001575.1	0.18	NRP	dipeptide aldehydes	Ruminococcus sp. 5_1_39BFAA
BGC0001871.1	0.18	NRP	L-2-amino-4-methoxy-trans-3-butenoic acid	Pseudomonas aeruginosa PAO1
BGC0000287.1	0.17	NRP	L-2-amino-4-methoxy-trans-3-butenoic acid	Pseudomonas aeruginosa PAO1
BGC0000876.1	0.17	Other	neopolyoxin C	Streptomyces tendae
BGC0000715.1	0.16	Saccharide	actinospectacin	Streptomyces spectabilis
BGC0001561.1	0.16	NRP	curacomycin	Streptomyces curacoi

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000382.1	1.00	NRP	lipstatin	Streptomyces toxytricini
BGC0001458.1	0.61	Other, , (, A, m, i, n, o, c, o, u, m, a, r, i, n, )	salinipostin G	Salinispora tropica CNB-440
BGC0000871.1	0.61	Other, , (, N, u, c, l, e, o, s, i, d, e, )	VEPE, AEPE, TG-1	Myxococcus xanthus DK 1622
BGC0001168.1	0.52	NRP	livipeptin	Streptomyces lividans 1326
BGC0001575.1	0.49	NRP	dipeptide aldehydes	Ruminococcus sp. 5_1_39BFAA
BGC0001871.1	0.49	NRP	L-2-amino-4-methoxy-trans-3-butenoic acid	Pseudomonas aeruginosa PAO1
BGC0000287.1	0.48	NRP	L-2-amino-4-methoxy-trans-3-butenoic acid	Pseudomonas aeruginosa PAO1
BGC0000876.1	0.47	Other	neopolyoxin C	Streptomyces tendae
BGC0000715.1	0.47	Saccharide	actinospectacin	Streptomyces spectabilis
BGC0001561.1	0.47	NRP	curacomycin	Streptomyces curacoi

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 19400:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

lstC

Search NORINE for peptide: strict or relaxed

AMP-binding (27..488): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DLsFvGtPiK
Nearest Stachelhaus code:: ala
Stachelhaus code match:: 60% (weak)

lstE

Search NORINE for peptide: strict or relaxed

AMP-binding (824..1224): X

NRPSPredictor2: gly, ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: gly, ala
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DifALGGvAK
Nearest Stachelhaus code:: leu
Stachelhaus code match:: 70% (weak)