BGC0000467 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000467 (Yersinia enterocolitica)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	13,629	yersiniabactin	NRP + Polyketide	5%

BGC0000467 - Region 1 - T1PKS

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Location: 1 - 13,629 nt. (total: 13,629 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 13,630
Label		BGC0000467

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000467.1	0.56	NRP	yersiniabactin	Yersinia enterocolitica
BGC0001055.1	0.25	NRP, Polyketide	yersiniabactin	Escherichia coli
BGC0000056.1	0.23	Polyketide	esperamicin	Actinomadura verrucosospora
BGC0000393.1	0.19	NRP, Polyketide	myxoprincomide-c506	Myxococcus xanthus DK 1622
BGC0001124.1	0.18	Polyketide	pyranonigrin E	Aspergillus niger ATCC 1015
BGC0001399.1	0.18	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0001444.1	0.18	Other	caboxamycin	Streptomyces sp. NTK 937
BGC0001538.1	0.18	NRP, Polyketide	caboxamycin	Streptomyces sp. NTK 937
BGC0001517.1	0.17	NRP	asperphenamate	Aspergillus terreus NIH2624
BGC0000057.1	0.17	Polyketide	F9775A, F9775B, orsellinic acid	Aspergillus nidulans FGSC A4

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000467.1	0.82	NRP	yersiniabactin	Yersinia enterocolitica
BGC0001055.1	0.59	NRP, Polyketide	yersiniabactin	Escherichia coli
BGC0000056.1	0.57	Polyketide	esperamicin	Actinomadura verrucosospora
BGC0000393.1	0.51	NRP, Polyketide	myxoprincomide-c506	Myxococcus xanthus DK 1622
BGC0001124.1	0.50	Polyketide	pyranonigrin E	Aspergillus niger ATCC 1015
BGC0001399.1	0.49	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0001444.1	0.49	Other	caboxamycin	Streptomyces sp. NTK 937
BGC0001538.1	0.49	NRP, Polyketide	caboxamycin	Streptomyces sp. NTK 937
BGC0001517.1	0.49	NRP	asperphenamate	Aspergillus terreus NIH2624
BGC0000057.1	0.49	Polyketide	F9775A, F9775B, orsellinic acid	Aspergillus nidulans FGSC A4

Similar known gene clusters

Module view

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 13629:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-ohmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

irp1

PKS_AT (552..842): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 62.5%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 129.4
Methoxymalonyl-CoA: 47.3
inactive: 45.3
Methylmalonyl-CoA: 41.0
Benzoyl-CoA: 38.6
Propionyl-CoA: 31.1
Isobutyryl-CoA: 26.0
fatty_acid: 21.7
Acetyl-CoA: 20.1
2-Methylbutyryl-CoA: 19.5
3-Methylbutyryl-CoA: 15.6
CHC-CoA: 12.5
Ethylmalonyl-CoA: 4.3
trans-1,2-CPDA: 0.0

irp5

Search NORINE for peptide: strict or relaxed

AMP-binding (20..422): dhb

NRPSPredictor2: dhb

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: dhb, sal
Small clusters prediction:: dhb, sal
Single AA prediction:: dhb

Stachelhaus prediction details:

Stachelhaus sequence:: PLPAQGVLCK
Nearest Stachelhaus code:: dhb
Stachelhaus code match:: 100% (strong)