BGC0001105 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001105 (symbiont bacterium of Theonella swinhoei)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	transAT-PKS-like,NRPS,T3PKS	1	36,513	pederin / pseudopederin / pederone	Polyketide:Trans-AT type I	18%

BGC0001105 - Region 1 - NRPS,T3PKS,transAT-PKS-like

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Location: 1 - 36,513 nt. (total: 36,513 nt) Show pHMM detection rules used

Region on contig edge.

transAT-PKS-like: cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS) and not PKS_AT)
NRPS: cds(Condensation and (AMP-binding or A-OX))
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 36,514
Label		BGC0001105

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001105.1	1.95	NRP, Polyketide	onnamide A	Uncultured bacterium
BGC0002057.1	0.63	Polyketide	pateamine	Kiritimatiellaeota bacterium
BGC0001458.1	0.56	Other, , (, A, m, i, n, o, c, o, u, m, a, r, i, n, )	salinipostin G	Salinispora tropica CNB-440
BGC0000180.1	0.56	Polyketide	legioliulin	Legionella parisiensis
BGC0000205.1	0.55	Polyketide	bryostatin	Candidatus Endobugula sertula
BGC0000255.1	0.50	Polyketide	pederin	Uncultured bacterium
BGC0001235.1	0.49	NRP, Polyketide	antalid	Polyangium spumosum
BGC0001991.1	0.49	Polyketide	toblerol A, toblerol B, toblerol C, toblerol D, toblerol E, toblerol F, toblerol G, toblerol H	Methylorubrum extorquens AM1
BGC0001664.1	0.49	Terpene	merosterol	Scytonema sp. PCC 10023
BGC0000393.1	0.48	NRP, Polyketide	myxoprincomide-c506	Myxococcus xanthus DK 1622

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001105.1	0.91	NRP, Polyketide	onnamide A	Uncultured bacterium
BGC0000205.1	0.61	Polyketide	bryostatin	Candidatus Endobugula sertula
BGC0002057.1	0.58	Polyketide	pateamine	Kiritimatiellaeota bacterium
BGC0001104.1	0.57	NRP, Polyketide	myxovirescin A1	Myxococcus xanthus DK 1622
BGC0001050.1	0.55	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0001878.1	0.53	NRP, Polyketide	detoxin N2, detoxin N3	Streptomyces sp. NRRL B-1347
BGC0001841.1	0.52	NRP, Polyketide	detoxin P1, detoxin P2, detoxin P3	Amycolatopsis jejuensis
BGC0000180.1	0.52	Polyketide	legioliulin	Legionella parisiensis
BGC0001840.1	0.52	NRP, Polyketide	detoxin S1	Streptomyces sp. NRRL S-325
BGC0001458.1	0.51	Other, , (, A, m, i, n, o, c, o, u, m, a, r, i, n, )	salinipostin G	Salinispora tropica CNB-440

Similar known gene clusters

Module view

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 36513:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (OMe-ohmal - mal - mal) + (mal - gly - ohmal - OMe-ohmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 0 - 21721:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (OMe-ohmal - mal - mal) + (mal - gly - ohmal - OMe-ohmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

onnI

Search NORINE for peptide: strict or relaxed

AMP-binding (1307..1707): gly

NRPSPredictor2: gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: gly, ala
Single AA prediction:: gly

Stachelhaus prediction details:

Stachelhaus sequence:: DILQLGLIWK
Nearest Stachelhaus code:: gly
Stachelhaus code match:: 100% (strong)