BGC0001179 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001179 (Streptomyces bottropensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS,PKS-like	1	46,538	High	rishirilide B/rishirilide A	PKS:Type II

BGC0001179 - Region 1 - PKS-like,T2PKS

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Location: 1 - 46,538 nt. (total: 46,538 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)
PKS-like: (t2pks2 or ksIII)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 46,539
Label		BGC0001179

Tailoring functions

Oxidoreductases: Hydroxylation dehydrogenase oxidoreductase oxygenase

rslO10: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

rslO2: flavin reductase domain protein FMN-binding

smcogs: SMCOG1160: flavin reductase domain protein FMN-binding

rslO3: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

rslO4: Hydroxylation

MITE: MITE0000087Hydroxylation (identity: 100.00%)

rslO5: NADH:flavin oxidoreductase/NADH oxidase

smcogs: SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase

rslO7: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

rslO8: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

rslO9: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

Transferases: acylase

rslA: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Lyases: cyclase

rslC1: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

Ligases: synthase

rslK2: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

rslK3: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

rslK4: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001179.5	1.77	PKS	rishirilide B, rishirilide A	Streptomyces bottropensis
BGC0002154.2	0.59	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0002175.3	0.58	PKS	YWA1	Aspergillus oryzae RIB40
BGC0000037.4	0.58	PKS	cichorine	Aspergillus nidulans FGSC A4
BGC0000272.3	0.56	PKS	spore pigment	Streptomyces collinus
BGC0000041.3	0.56	PKS	oronofacic acid	Pseudomonas syringae
BGC0001164.3	0.56	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000234.5	0.49	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000231.5	0.47	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000271.5	0.46	PKS	spore pigment	Streptomyces avermitilis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001179.5	1.00	PKS	rishirilide B, rishirilide A	Streptomyces bottropensis
BGC0002154.2	0.63	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0002175.3	0.63	PKS	YWA1	Aspergillus oryzae RIB40
BGC0000041.3	0.63	PKS	oronofacic acid	Pseudomonas syringae
BGC0000037.4	0.63	PKS	cichorine	Aspergillus nidulans FGSC A4
BGC0000272.3	0.62	PKS	spore pigment	Streptomyces collinus
BGC0001164.3	0.61	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000271.5	0.56	PKS	spore pigment	Streptomyces avermitilis
BGC0000234.5	0.54	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000231.5	0.54	PKS	griseusin A, griseusin B	Streptomyces griseus

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

rslA: pk

PKS_AT (0..269): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 58.3%

minowa: Methoxymalonyl-CoA

Prediction, score:

Methoxymalonyl-CoA: 23.6
Malonyl-CoA: 21.9
Methylmalonyl-CoA: 21.7
trans-1,2-CPDA: 0.0
inactive: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor

Type II PKS gene cluster prediction details

Cluster section:: 0 to 46538
Starter unit(s):: isobutyryl-CoA (Score: 1362.0; E-value: 0)

rslA: AT (Score: 414.2; E-value: 9.2e-127); AT AHL46711.1_Rishirilide_isobutyryl-CoA (Score: 656.0; E-value: 0.0)
rslC1: CYC C7-C12 (Score: 444.1; E-value: 4.9e-136)
rslC2: CYC C5-C14 (Score: 449.8; E-value: 9.3e-138)
rslC3: CYC C1-C18|C2-C19 (Score: 220.9; E-value: 1.2e-68)
rslK1: ACP (Score: 123.0; E-value: 8.5e-39)
rslK2: CLF (Score: 634.8; E-value: 1.2e-193)
rslK3: KS (Score: 751.8; E-value: 4.1e-229)
rslK4: KSIII (Score: 504.7; E-value: 2.8e-154); KSIII AHL46712.1_Rishirilide_isobutyryl-CoA (Score: 706.0; E-value: 0.0)
rslO10: KR C9 (Score: 462.4; E-value: 8.9e-142)
rslO3: KR (Score: 188.0; E-value: 5.8e-58)
rslO9: OXY (Score: 246.1; E-value: 1.8e-75)