BGC0001203 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001203 (uncultured bacterium AR_456)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS,NRPS	1	37,516	epoxomicin	NRP + Polyketide:Modular type I	50%

BGC0001203 - Region 1 - NRPS,T1PKS

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Location: 1 - 37,516 nt. (total: 37,516 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 37,517
Label		BGC0001203

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001203.1	1.54	NRP, Polyketide	clarexpoxcin	uncultured bacterium AR_456
BGC0001909.1	0.62	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001833.1	0.56	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001068.1	0.55	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0001135.1	0.55	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001128.1	0.54	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001844.1	0.52	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001132.1	0.51	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001758.1	0.51	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001825.1	0.51	NRP	xenematide	Xenorhabdus nematophila AN6/1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001203.1	0.92	NRP, Polyketide	clarexpoxcin	uncultured bacterium AR_456
BGC0001909.1	0.64	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001833.1	0.62	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001068.1	0.61	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0001135.1	0.61	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001128.1	0.60	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001844.1	0.60	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001132.1	0.59	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001758.1	0.59	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001825.1	0.59	NRP	xenematide	Xenorhabdus nematophila AN6/1

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 37516:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (NMe-val - thr - thr - X) + (Me-mal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 0 - 36992:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (NMe-val - thr - thr - X) + (Me-mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

AKA59447.1

Search NORINE for peptide: strict or relaxed

AMP-binding (461..853): val

NRPSPredictor2: val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: val

Stachelhaus prediction details:

Stachelhaus sequence:: DAYFWGVTFK
Nearest Stachelhaus code:: val
Stachelhaus code match:: 100% (strong)

AMP-binding (2083..2471): thr

NRPSPredictor2: thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: thr
Single AA prediction:: thr

Stachelhaus prediction details:

Stachelhaus sequence:: DFWNIGgifK
Nearest Stachelhaus code:: thr
Stachelhaus code match:: 70% (weak)

AMP-binding (2830..3222): thr

NRPSPredictor2: thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: thr
Single AA prediction:: thr

Stachelhaus prediction details:

Stachelhaus sequence:: DFWNIGMVHK
Nearest Stachelhaus code:: thr
Stachelhaus code match:: 100% (strong)

AMP-binding (4116..4499): X

NRPSPredictor2: hydrophobic-aliphatic

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DmaSVGgVfK
Nearest Stachelhaus code:: thr
Stachelhaus code match:: 60% (weak)

AKA59448.1

PKS_AT (512..796): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 70.8%; inactive: 58.3%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 73.9
inactive: 31.9
Methoxymalonyl-CoA: 18.6
Methylmalonyl-CoA: 13.5
Propionyl-CoA: 5.6
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0