BGC0001349 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001349 (Streptomyces marincola)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	84,595	BE-14106	Polyketide:Modular type I	64%

BGC0001349 - Region 1 - T1PKS

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Location: 1 - 84,595 nt. (total: 84,595 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 84,596
Label		BGC0001349

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001349.1	0.73	NRP, Polyketide	heronamide A, heronamide B, heronamide C, heronamide D, heronamide E, heronamide F	Streptomyces sp. SCSIO 03032
BGC0000097.1	0.35	Polyketide	ML-449	Streptomyces sp. MP39-85
BGC0000029.1	0.32	Polyketide	BE-14106	Streptomyces sp. DSM 21069
BGC0000935.1	0.30	Other, Polyketide, , (, A, m, i, n, o, c, o, u, m, a, r, i, n, )	esmeraldin	Streptomyces antibioticus
BGC0001273.1	0.30	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001275.1	0.30	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001276.1	0.30	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.1	0.30	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0000120.1	0.29	Polyketide	patulin	Penicillium expansum
BGC0000160.1	0.29	Polyketide	terreic acid	Aspergillus terreus NIH2624

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001349.1	0.90	NRP, Polyketide	heronamide A, heronamide B, heronamide C, heronamide D, heronamide E, heronamide F	Streptomyces sp. SCSIO 03032
BGC0000097.1	0.68	Polyketide	ML-449	Streptomyces sp. MP39-85
BGC0000029.1	0.65	Polyketide	BE-14106	Streptomyces sp. DSM 21069
BGC0000935.1	0.64	Other, Polyketide, , (, A, m, i, n, o, c, o, u, m, a, r, i, n, )	esmeraldin	Streptomyces antibioticus
BGC0001273.1	0.63	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001275.1	0.63	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001276.1	0.63	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.1	0.63	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0000120.1	0.63	Polyketide	patulin	Penicillium expansum
BGC0000160.1	0.62	Polyketide	terreic acid	Aspergillus terreus NIH2624

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 84595:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-mal - ccmal - ccmal) + (ccmal - pk) + (ccmal - ccmal) + (pk - ccmal) + (ccmal) + (ccmal)
Non-colinear ordering:: AKD43768.1 + AKD43753.1 + AKD43761.1 + AKD43764.1 + AKD43765.1 + AKD43763.1

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

AKD43753.1

PKS_AT (646..939): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 203.8
inactive: 113.4
Methoxymalonyl-CoA: 62.4
Methylmalonyl-CoA: 53.9
Propionyl-CoA: 38.4
Isobutyryl-CoA: 34.0
2-Methylbutyryl-CoA: 22.8
Acetyl-CoA: 15.8
Benzoyl-CoA: 14.8
Ethylmalonyl-CoA: 14.6
trans-1,2-CPDA: 10.2
CHC-CoA: 8.8
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2340..2638): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 221.5
Methylmalonyl-CoA: 217.3
Methoxymalonyl-CoA: 178.5
trans-1,2-CPDA: 153.0
2-Methylbutyryl-CoA: 140.6
Propionyl-CoA: 113.4
Malonyl-CoA: 110.9
CHC-CoA: 93.1
Benzoyl-CoA: 86.9
Isobutyryl-CoA: 77.3
Acetyl-CoA: 52.9
3-Methylbutyryl-CoA: 46.6
fatty_acid: 43.7
inactive: 30.4

AKD43754.1

Search NORINE for peptide: strict or relaxed

AMP-binding (24..436): X

NRPSPredictor2: hydrophobic-aliphatic

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DfFdVtGaaK
Nearest Stachelhaus code:: ala
Stachelhaus code match:: 50% (weak)

AKD43755.1

PKS_AT (4..267): pk

ATSignature: (unknown)

No matches above 50%

minowa: Propionyl-CoA

Prediction, score:

Propionyl-CoA: 15.7
CHC-CoA: 14.5
Methylmalonyl-CoA: 11.5
Methoxymalonyl-CoA: 9.6
2-Methylbutyryl-CoA: 9.1
Ethylmalonyl-CoA: 8.2
trans-1,2-CPDA: 0.0
inactive: 0.0
fatty_acid: 0.0
Malonyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

AKD43757.1

Search NORINE for peptide: strict or relaxed

AMP-binding (18..405): X

NRPSPredictor2: val, leu, ile, abu, iva

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DcffFaLItK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 50% (weak)

AKD43761.1

PKS_AT (552..831): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 75.0%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 205.6
inactive: 99.1
Methylmalonyl-CoA: 62.9
Methoxymalonyl-CoA: 62.6
Propionyl-CoA: 46.5
Isobutyryl-CoA: 34.4
CHC-CoA: 27.8
Ethylmalonyl-CoA: 26.9
Benzoyl-CoA: 22.9
fatty_acid: 21.9
2-Methylbutyryl-CoA: 21.5
Acetyl-CoA: 20.9
trans-1,2-CPDA: 9.9
3-Methylbutyryl-CoA: 0.0

PKS_AT (2171..2446): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 75.0%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 195.2
inactive: 107.8
Methoxymalonyl-CoA: 61.5
Methylmalonyl-CoA: 56.6
Isobutyryl-CoA: 33.9
Ethylmalonyl-CoA: 31.6
Propionyl-CoA: 30.6
Benzoyl-CoA: 25.1
Acetyl-CoA: 24.6
fatty_acid: 19.2
trans-1,2-CPDA: 18.6
2-Methylbutyryl-CoA: 15.5
CHC-CoA: 14.1
3-Methylbutyryl-CoA: 0.0

AKD43763.1

PKS_AT (552..828): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 75.0%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 190.6
inactive: 103.5
Methoxymalonyl-CoA: 60.6
Methylmalonyl-CoA: 54.2
Isobutyryl-CoA: 32.3
Ethylmalonyl-CoA: 31.6
Propionyl-CoA: 27.2
Benzoyl-CoA: 25.1
Acetyl-CoA: 24.6
fatty_acid: 19.2
trans-1,2-CPDA: 18.6
2-Methylbutyryl-CoA: 15.8
CHC-CoA: 14.1
3-Methylbutyryl-CoA: 0.0

AKD43764.1

PKS_AT (558..832): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 197.5
Methylmalonyl-CoA: 197.1
Methoxymalonyl-CoA: 155.7
2-Methylbutyryl-CoA: 135.0
CHC-CoA: 102.8
Propionyl-CoA: 102.2
trans-1,2-CPDA: 102.1
Malonyl-CoA: 74.0
Isobutyryl-CoA: 68.3
Benzoyl-CoA: 47.4
3-Methylbutyryl-CoA: 36.7
Acetyl-CoA: 32.9
fatty_acid: 30.1
inactive: 19.2

PKS_AT (2201..2476): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 209.2
inactive: 100.1
Methoxymalonyl-CoA: 59.8
Methylmalonyl-CoA: 53.1
Isobutyryl-CoA: 35.4
Propionyl-CoA: 29.5
Acetyl-CoA: 26.8
Ethylmalonyl-CoA: 24.7
Benzoyl-CoA: 23.3
2-Methylbutyryl-CoA: 20.4
CHC-CoA: 15.7
fatty_acid: 14.4
trans-1,2-CPDA: 14.0
3-Methylbutyryl-CoA: 0.0

AKD43765.1

PKS_AT (529..805): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 75.0%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 190.6
inactive: 103.5
Methoxymalonyl-CoA: 60.6
Methylmalonyl-CoA: 54.2
Isobutyryl-CoA: 32.3
Ethylmalonyl-CoA: 31.6
Propionyl-CoA: 27.2
Benzoyl-CoA: 25.1
Acetyl-CoA: 24.6
fatty_acid: 19.2
trans-1,2-CPDA: 18.6
2-Methylbutyryl-CoA: 15.8
CHC-CoA: 14.1
3-Methylbutyryl-CoA: 0.0

AKD43768.1

PKS_AT (534..827): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 200.6
Ethylmalonyl-CoA: 195.9
Methoxymalonyl-CoA: 168.3
2-Methylbutyryl-CoA: 143.0
trans-1,2-CPDA: 125.2
Propionyl-CoA: 111.4
Malonyl-CoA: 93.9
CHC-CoA: 91.3
Isobutyryl-CoA: 69.4
Benzoyl-CoA: 60.0
Acetyl-CoA: 57.6
inactive: 42.8
fatty_acid: 32.9
3-Methylbutyryl-CoA: 32.7

PKS_AT (1551..1848): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 87.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 199.0
inactive: 102.4
Methoxymalonyl-CoA: 53.0
Methylmalonyl-CoA: 38.2
Isobutyryl-CoA: 29.0
Propionyl-CoA: 28.4
Acetyl-CoA: 20.3
Ethylmalonyl-CoA: 19.7
Benzoyl-CoA: 19.5
2-Methylbutyryl-CoA: 10.0
CHC-CoA: 9.8
trans-1,2-CPDA: 6.5
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (3342..3636): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 87.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 197.2
inactive: 107.5
Methoxymalonyl-CoA: 50.2
Methylmalonyl-CoA: 34.9
Propionyl-CoA: 24.0
Isobutyryl-CoA: 22.6
Acetyl-CoA: 18.3
Benzoyl-CoA: 11.4
CHC-CoA: 10.1
Ethylmalonyl-CoA: 8.5
2-Methylbutyryl-CoA: 8.5
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

AKD43769.1

PKS_AT (567..859): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 66.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 192.5
inactive: 85.7
Methoxymalonyl-CoA: 57.7
Methylmalonyl-CoA: 45.8
Isobutyryl-CoA: 33.6
Propionyl-CoA: 28.5
Acetyl-CoA: 20.7
Ethylmalonyl-CoA: 18.3
Benzoyl-CoA: 13.3
fatty_acid: 12.3
CHC-CoA: 9.7
2-Methylbutyryl-CoA: 9.3
trans-1,2-CPDA: 7.7
3-Methylbutyryl-CoA: 0.0