BGC0001384 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001384 (Streptomyces sp. TK08046)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T2PKS,oligosaccharide	1	44,148	saquayamycin A	Polyketide	80%

BGC0001384 - Region 1 - T2PKS,oligosaccharide

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Location: 1 - 44,148 nt. (total: 44,148 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)
oligosaccharide: (minimum(3, [DUF1205, Glyco_transf_28, Glycos_transf_1, Glycos_transf_2, MGT]) and minscore(MGT, 150))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 44,149
Label		BGC0001384

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001384.1	1.78	Polyketide	saprolmycin E	Streptomyces sp. TK08046
BGC0000231.1	1.19	Polyketide	griseusin	Streptomyces griseus
BGC0001769.1	1.19	Polyketide	saquayamycin A	Streptomyces sp.
BGC0000229.1	1.05	Polyketide, Saccharide	grincamycin	Streptomyces lusitanus
BGC0000234.1	0.99	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000248.1	0.99	Polyketide	naphtocyclinone	Streptomyces arenae
BGC0000278.1	0.84	Polyketide	urdamycin	Streptomyces fradiae
BGC0001723.1	0.84	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0000268.1	0.64	Polyketide	Sch-47554, Sch-47555	Streptomyces sp. SCC 2136
BGC0000228.1	0.58	Polyketide	granaticin	Streptomyces violaceoruber

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001384.1	1.00	Polyketide	saprolmycin E	Streptomyces sp. TK08046
BGC0001769.1	0.84	Polyketide	saquayamycin A	Streptomyces sp.
BGC0000231.1	0.84	Polyketide	griseusin	Streptomyces griseus
BGC0000229.1	0.79	Polyketide, Saccharide	grincamycin	Streptomyces lusitanus
BGC0000234.1	0.78	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000248.1	0.78	Polyketide	naphtocyclinone	Streptomyces arenae
BGC0001723.1	0.75	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0000278.1	0.73	Polyketide	urdamycin	Streptomyces fradiae
BGC0000264.1	0.65	Polyketide	resistomycin, resistoflavine	Streptomyces resistomycificus
BGC0000228.1	0.62	Polyketide	granaticin	Streptomyces violaceoruber

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Type II PKS

Predicted core structure(s)

For candidate cluster 1, location 0 - 44148:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

spr1

PKS_AT (8..300): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; inactive: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 79.1
Methoxymalonyl-CoA: 49.4
Methylmalonyl-CoA: 46.6
fatty_acid: 28.8
CHC-CoA: 26.3
Benzoyl-CoA: 23.9
Propionyl-CoA: 20.9
trans-1,2-CPDA: 19.3
2-Methylbutyryl-CoA: 18.5
Ethylmalonyl-CoA: 17.9
Isobutyryl-CoA: 14.6
Acetyl-CoA: 13.8
inactive: 12.8
3-Methylbutyryl-CoA: 0.0

Type II PKS gene cluster prediction details

Cluster section:: 0 to 44148
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 721.0; E-value: 7.7e-220)
Product class(es):: angucycline
Product molecular weight(s):: acetyl-CoA_8: 905.82 Da
acetyl-CoA_9: 947.86 Da

sprB: OXY (Score: 628.8; E-value: 1.5e-191)
sprC: CYC C4-C17/C2-C19 (Score: 201.7; E-value: 2.5e-62)
sprD: KS (Score: 804.4; E-value: 4.5e-245)
sprE: CLF 8|9 (Score: 721.0; E-value: 7.7e-220)
sprF: ACP (Score: 144.8; E-value: 1.4e-45)
sprG: KR C9 (Score: 495.5; E-value: 7e-152)
sprGT1: GT (Score: 457.1; E-value: 1.6e-139)
sprGT2: GT (Score: 432.3; E-value: 5e-132)
sprGT3: GT (Score: 414.7; E-value: 1.1e-126)
sprH: CYC C7-C12 (Score: 508.5; E-value: 1.2e-155)
sprI: OXY (Score: 628.8; E-value: 1.4e-191)