BGC0001598 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001598 (Streptomyces diastatochromogenes)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	57,596	acarbose	Saccharide	10%

BGC0001598 - Region 1 - T1PKS

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Location: 1 - 57,596 nt. (total: 57,596 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 57,597
Label		BGC0001598

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001598.1	0.62	NRP, Polyketide	foxicins A-D	Streptomyces diastatochromogenes
BGC0001343.1	0.29	Polyketide	aurachin A, aurachin D	Stigmatella aurantiaca Sg a15
BGC0001377.1	0.26	Polyketide	uncialamycin	Streptomyces uncialis
BGC0001815.1	0.26	Polyketide	uncialamycin	Streptomyces uncialis
BGC0001161.1	0.25	Polyketide	1-heptadecene	Moorea bouillonii PNG
BGC0001163.1	0.25	Polyketide	1-heptadecene	Moorea producens 3L
BGC0001162.1	0.25	Polyketide	1-heptadecene	Moorea producens JHB
BGC0001831.1	0.25	Polyketide	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0001458.1	0.24	Other, , (, A, m, i, n, o, c, o, u, m, a, r, i, n, )	salinipostin G	Salinispora tropica CNB-440
BGC0001441.1	0.24	Other	belactosin A, belactosin C	Streptomyces sp.

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001598.1	0.87	NRP, Polyketide	foxicins A-D	Streptomyces diastatochromogenes
BGC0001343.1	0.63	Polyketide	aurachin A, aurachin D	Stigmatella aurantiaca Sg a15
BGC0000410.1	0.60	NRP	pseudomonine	Pseudomonas fluorescens
BGC0001377.1	0.60	Polyketide	uncialamycin	Streptomyces uncialis
BGC0001815.1	0.60	Polyketide	uncialamycin	Streptomyces uncialis
BGC0001161.1	0.59	Polyketide	1-heptadecene	Moorea bouillonii PNG
BGC0001163.1	0.59	Polyketide	1-heptadecene	Moorea producens 3L
BGC0001162.1	0.59	Polyketide	1-heptadecene	Moorea producens JHB
BGC0001831.1	0.58	Polyketide	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0002000.1	0.58	Polyketide	setomimycin	Streptomyces aurantiacus JA 4570

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 3162 - 57586:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-ccmal - Me-ccmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

foxBI

CAL_domain (46..493): pk

minowa: NH2

Prediction, score:

NH2: 29.3
AHBA: 7.5
fatty_acid: 4.6
shikimic_acid: 2.7
Acetyl-CoA: 1.6

foxBII

PKS_AT (772..1068): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 200.0
Ethylmalonyl-CoA: 192.7
Methoxymalonyl-CoA: 167.5
2-Methylbutyryl-CoA: 130.1
trans-1,2-CPDA: 111.0
Propionyl-CoA: 96.3
CHC-CoA: 93.2
Malonyl-CoA: 92.8
Isobutyryl-CoA: 67.7
Benzoyl-CoA: 57.5
Acetyl-CoA: 47.9
3-Methylbutyryl-CoA: 28.2
inactive: 23.5
fatty_acid: 14.2

PKS_AT (2523..2819): mmal

ATSignature: Ethylmalonyl-CoA, Methylmalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 66.7%; Methylmalonyl-CoA: 66.7%; Propionyl-CoA: 62.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 149.0
Ethylmalonyl-CoA: 141.7
Methoxymalonyl-CoA: 141.3
Malonyl-CoA: 93.9
trans-1,2-CPDA: 84.2
2-Methylbutyryl-CoA: 80.7
CHC-CoA: 71.1
Propionyl-CoA: 67.3
Isobutyryl-CoA: 65.2
Benzoyl-CoA: 41.3
Acetyl-CoA: 31.7
fatty_acid: 27.8
inactive: 19.4
3-Methylbutyryl-CoA: 16.1