BGC0001637 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001637 (Klebsiella oxytoca)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	18,579	tilivalline / 9-deoxy tilivalline / dihydroxy tilivalline / dehydro tilivalline / dihydroxy-dehydro tilivalline	NRP:Pyrrolobenzodiazepine	57%

BGC0001637 - Region 1 - NRPS

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Location: 1 - 18,579 nt. (total: 18,579 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 18,580
Label		BGC0001637

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001637.1	0.96	NRP	kleboxymycin	Klebsiella oxytoca
BGC0001805.1	0.52	NRP	tilivalline	Klebsiella oxytoca
BGC0000446.1	0.52	NRP	tilivalline, 9-deoxy tilivalline, dihydroxy tilivalline, dehydro tilivalline, dihydroxy-dehydro tilivalline	Klebsiella oxytoca
BGC0001399.1	0.31	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0001724.1	0.26	NRP, Polyketide	oxaleimide C	Penicillium oxalicum 114-2
BGC0000983.1	0.25	NRP, Polyketide	cytochalasin E, cytochalasin K	Aspergillus clavatus NRRL 1
BGC0001574.1	0.24	NRP	diisonitrile antibiotic SF2768	Streptomyces thioluteus
BGC0001442.1	0.24	NRP	actinonin	Streptomyces sp. strain ATCC 14903
BGC0001497.1	0.24	Polyketide	actinonin	Streptomyces sp.
BGC0001627.1	0.24	NRP	isonitrile lipopeptides	Mycobacterium tuberculosis H37Rv

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001637.1	0.99	NRP	kleboxymycin	Klebsiella oxytoca
BGC0001805.1	0.80	NRP	tilivalline	Klebsiella oxytoca
BGC0000446.1	0.80	NRP	tilivalline, 9-deoxy tilivalline, dihydroxy tilivalline, dehydro tilivalline, dihydroxy-dehydro tilivalline	Klebsiella oxytoca
BGC0001399.1	0.65	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0001724.1	0.59	NRP, Polyketide	oxaleimide C	Penicillium oxalicum 114-2
BGC0000983.1	0.58	NRP, Polyketide	cytochalasin E, cytochalasin K	Aspergillus clavatus NRRL 1
BGC0001574.1	0.57	NRP	diisonitrile antibiotic SF2768	Streptomyces thioluteus
BGC0001442.1	0.57	NRP	actinonin	Streptomyces sp. strain ATCC 14903
BGC0001497.1	0.57	Polyketide	actinonin	Streptomyces sp.
BGC0001627.1	0.57	NRP	isonitrile lipopeptides	Mycobacterium tuberculosis H37Rv

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 18579:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

npsA

Search NORINE for peptide: strict or relaxed

AMP-binding (16..411): X

NRPSPredictor2: hydrophobic-aliphatic

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: aanfVsGaIK
Nearest Stachelhaus code:: pro
Stachelhaus code match:: 40% (weak)

npsB

Search NORINE for peptide: strict or relaxed

AMP-binding (482..883): X

NRPSPredictor2: hydrophobic-aliphatic

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVQYytlVcK
Nearest Stachelhaus code:: pro
Stachelhaus code match:: 60% (weak)