BGC0001702 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001702 (Saccharothrix syringae)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS,NRPS	1	68,204	tirandamycin	NRP + Polyketide:Modular type I	46%

BGC0001702 - Region 1 - NRPS,T1PKS

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Location: 1 - 68,204 nt. (total: 68,204 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 68,205
Label		BGC0001702

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001702.1	1.25	NRP, Polyketide	nocamycin	Saccharothrix syringae
BGC0000457.1	0.60	NRP	vicibactin	Rhizobium etli CFN 42
BGC0000321.1	0.55	NRP	chaetocin	Collariella virescens
BGC0002058.1	0.55	Other	Reutericyclin A, Reutericyclin B, Reutericyclin C, Reutericyclin D	Streptococcus mutans B04Sm5
BGC0000228.1	0.54	Polyketide	granaticin	Streptomyces violaceoruber
BGC0000122.1	0.54	Polyketide	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla
BGC0000217.1	0.53	Polyketide	daunorubicin	Streptomyces sp.
BGC0001873.1	0.52	NRP	pyrrolizixenamide A	Xenorhabdus szentirmaii DSM 16338
BGC0001585.1	0.52	Alkaloid	melinacidin IV	Escovopsis weberi
BGC0000313.1	0.52	NRP	beauvericin	Beauveria bassiana

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001702.1	0.94	NRP, Polyketide	nocamycin	Saccharothrix syringae
BGC0000067.1	0.66	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000160.1	0.64	Polyketide	terreic acid	Aspergillus terreus NIH2624
BGC0001012.1	0.64	NRP, Polyketide	meridamycin	Streptomyces violaceusniger
BGC0000122.1	0.64	Polyketide	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla
BGC0000457.1	0.64	NRP	vicibactin	Rhizobium etli CFN 42
BGC0000170.1	0.64	Polyketide	yanuthone D	Aspergillus niger ATCC 1015
BGC0001275.1	0.64	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.1	0.64	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001273.1	0.64	Polyketide	asperlactone	Aspergillus ochraceus

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 68204:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (gly) + (mal - Me-ohmal - Me-mal - ohmal) + (Me-ccmal) + (Me-ohmal) + (Me-ccmal) + (ccmal - mal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 0 - 36840:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (gly) + (mal - Me-ohmal - Me-mal - ohmal) + (Me-ccmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ARS01470.1

Search NORINE for peptide: strict or relaxed

AMP-binding (659..918): gly

NRPSPredictor2: gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: gly, ala
Single AA prediction:: gly

Stachelhaus prediction details:

Stachelhaus sequence:: DILQLGVIWK
Nearest Stachelhaus code:: gly
Stachelhaus code match:: 100% (strong)

ARS01473.1

PKS_AT (435..715): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 75.0%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 179.6
inactive: 71.0
Methoxymalonyl-CoA: 59.7
Methylmalonyl-CoA: 58.3
Propionyl-CoA: 34.6
Isobutyryl-CoA: 34.6
Ethylmalonyl-CoA: 29.7
Acetyl-CoA: 20.8
fatty_acid: 20.4
Benzoyl-CoA: 18.9
2-Methylbutyryl-CoA: 18.2
CHC-CoA: 16.1
trans-1,2-CPDA: 14.4
3-Methylbutyryl-CoA: 4.9

PKS_AT (1511..1808): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 226.5
Ethylmalonyl-CoA: 217.3
Methoxymalonyl-CoA: 177.6
2-Methylbutyryl-CoA: 150.7
trans-1,2-CPDA: 134.8
Malonyl-CoA: 126.8
Propionyl-CoA: 120.8
CHC-CoA: 105.8
Benzoyl-CoA: 80.5
Isobutyryl-CoA: 78.1
Acetyl-CoA: 70.9
fatty_acid: 47.9
3-Methylbutyryl-CoA: 45.7
inactive: 39.4

PKS_AT (3008..3298): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 194.8
Ethylmalonyl-CoA: 181.4
Methoxymalonyl-CoA: 156.3
2-Methylbutyryl-CoA: 124.9
Propionyl-CoA: 116.3
Malonyl-CoA: 103.0
trans-1,2-CPDA: 95.0
CHC-CoA: 83.7
Isobutyryl-CoA: 71.8
Acetyl-CoA: 55.8
Benzoyl-CoA: 51.7
inactive: 37.7
3-Methylbutyryl-CoA: 37.3
fatty_acid: 26.6

PKS_AT (3936..4217): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 70.8%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 155.4
Methoxymalonyl-CoA: 73.7
Methylmalonyl-CoA: 72.6
inactive: 54.8
Propionyl-CoA: 50.6
Isobutyryl-CoA: 41.4
Ethylmalonyl-CoA: 35.9
Benzoyl-CoA: 28.8
fatty_acid: 26.4
CHC-CoA: 26.1
2-Methylbutyryl-CoA: 20.1
Acetyl-CoA: 18.4
trans-1,2-CPDA: 14.0
3-Methylbutyryl-CoA: 12.1

ARS01474.1

PKS_AT (550..826): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 202.7
Ethylmalonyl-CoA: 193.9
Methoxymalonyl-CoA: 161.4
2-Methylbutyryl-CoA: 129.3
Propionyl-CoA: 117.6
Malonyl-CoA: 105.5
trans-1,2-CPDA: 101.1
CHC-CoA: 99.7
Isobutyryl-CoA: 79.8
Benzoyl-CoA: 61.7
Acetyl-CoA: 55.9
3-Methylbutyryl-CoA: 43.1
inactive: 33.0
fatty_acid: 27.3

ARS01475.1

PKS_AT (561..851): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 207.9
Ethylmalonyl-CoA: 202.7
Methoxymalonyl-CoA: 169.6
2-Methylbutyryl-CoA: 132.8
Propionyl-CoA: 117.3
trans-1,2-CPDA: 109.3
Malonyl-CoA: 108.5
CHC-CoA: 100.7
Isobutyryl-CoA: 81.8
Benzoyl-CoA: 67.7
Acetyl-CoA: 57.4
3-Methylbutyryl-CoA: 52.0
inactive: 36.2
fatty_acid: 32.5

ARS01476.1

PKS_AT (559..849): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 205.3
Ethylmalonyl-CoA: 200.0
Methoxymalonyl-CoA: 166.0
2-Methylbutyryl-CoA: 128.8
Propionyl-CoA: 110.9
trans-1,2-CPDA: 106.1
Malonyl-CoA: 102.4
CHC-CoA: 100.4
Isobutyryl-CoA: 78.5
Benzoyl-CoA: 69.0
Acetyl-CoA: 56.7
3-Methylbutyryl-CoA: 48.8
inactive: 35.3
fatty_acid: 28.8

ARS01477.1

PKS_AT (557..825): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 177.3
Methoxymalonyl-CoA: 88.0
Methylmalonyl-CoA: 76.0
inactive: 74.3
Propionyl-CoA: 53.1
Isobutyryl-CoA: 48.1
fatty_acid: 46.1
Ethylmalonyl-CoA: 37.1
2-Methylbutyryl-CoA: 31.1
Acetyl-CoA: 28.5
Benzoyl-CoA: 28.0
CHC-CoA: 22.5
trans-1,2-CPDA: 17.5
3-Methylbutyryl-CoA: 9.3

PKS_AT (2180..2464): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%; Methylmalonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 163.8
Methylmalonyl-CoA: 67.2
Methoxymalonyl-CoA: 67.1
inactive: 65.9
Isobutyryl-CoA: 51.6
Propionyl-CoA: 39.7
Ethylmalonyl-CoA: 28.6
2-Methylbutyryl-CoA: 25.7
CHC-CoA: 22.8
Benzoyl-CoA: 18.8
Acetyl-CoA: 18.4
fatty_acid: 16.6
trans-1,2-CPDA: 14.0
3-Methylbutyryl-CoA: 3.2