BGC0000526 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000526 (Streptococcus macedonicus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	lanthipeptide-class-ii	1	15,171	streptococcin A-FF22	RiPP:Lanthipeptide	90%

BGC0000526 - Region 1 - lanthipeptide-class-ii

Download region GenBank file

Download region SVG

Location: 1 - 15,171 nt. (total: 15,171 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG

MIBiG comparison

KnownClusterBlast

Lanthipeptides

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 15,172
Label		BGC0000526

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000526.1	0.93	RiPP	macedocin	Streptococcus macedonicus
BGC0001788.1	0.51	RiPP	suicin 65	Streptococcus suis
BGC0000557.1	0.48	RiPP	streptococcin A-FF22	Streptococcus pyogenes
BGC0000550.1	0.40	RiPP	salivaricin G32	Streptococcus salivarius
BGC0000499.1	0.40	RiPP	butyrivibriocin OR79	Butyrivibrio fibrisolvens
BGC0000626.1	0.36	RiPP	thuricin	Bacillus thuringiensis
BGC0001787.1	0.36	RiPP	suicin 3908	Streptococcus suis
BGC0000528.1	0.36	RiPP	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000547.1	0.35	RiPP	salivaricin 9	Streptococcus salivarius
BGC0001579.1	0.33	RiPP	duramycin	Streptomyces cinnamoneus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000526.1	0.98	RiPP	macedocin	Streptococcus macedonicus
BGC0001788.1	0.79	RiPP	suicin 65	Streptococcus suis
BGC0000557.1	0.78	RiPP	streptococcin A-FF22	Streptococcus pyogenes
BGC0000550.1	0.72	RiPP	salivaricin G32	Streptococcus salivarius
BGC0000499.1	0.72	RiPP	butyrivibriocin OR79	Butyrivibrio fibrisolvens
BGC0000626.1	0.69	RiPP	thuricin	Bacillus thuringiensis
BGC0001787.1	0.69	RiPP	suicin 3908	Streptococcus suis
BGC0000528.1	0.68	RiPP	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000547.1	0.68	RiPP	salivaricin 9	Streptococcus salivarius
BGC0001579.1	0.67	RiPP	duramycin	Streptomyces cinnamoneus

Similar known gene clusters

Lanthipeptide predictions

Lanthipeptide(s) for mcdM

mcdA

Leader:

MEKETTIIESIQEVSLEELDQIIGA

mcdA_

Leader:

MEKETTIIESIQEVSLEELDQIIGA

Shared core:

GKNGVFKTISHECHLNTWAFLATCCS

Core with dehydrations:

GKNGVFKDhbIDhaHECysHLNDhbWAFLADhbCysCysDha

mcdA1

Leader:

MKNNNKICQDALESLQELKLEEVDELLGG

Core:

AGHGVNTISAECRWNSLQAIFSCC

Core with dehydrations:

AGHGVNDhbIDhaAECysRWNDhaLQAIFDhaCysCys

allorf_14551_14658

Leader:

VGLSYLSSNLVRYAVIGA

Core:

KIISYKIEWFSICHNHK

Core with dehydrations:

KIIDhaYKIEWFDhaICysHNHK

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

mcdA - Class II

Cleavage pHMM score: 5.20

RODEO score: 0

Monoisotopic mass: 2776.3 Da

Molecular weight: 2778.2 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2796.2 Da N = 1; 2814.2 Da N = 2

mcdA_ - Class II

Cleavage pHMM score: 5.20

RODEO score: 0

Monoisotopic mass: 2776.3 Da

Molecular weight: 2778.2 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2796.2 Da N = 1; 2814.2 Da N = 2

mcdA1 - Class II

Cleavage pHMM score: 0.40

RODEO score: 0

Monoisotopic mass: 2494.2 Da

Molecular weight: 2495.8 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2513.8 Da N = 1

allorf_14551_14658 - Class II

Cleavage pHMM score: -4.70

RODEO score: 0

Monoisotopic mass: 2109.1 Da

Molecular weight: 2110.5 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2128.5 Da N = 1