BGC0000951 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000951 (Streptomyces coeruleorubidus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS-like,NRPS	1	30,311	napsamycin A / napsamycin B / napsamycin C / napsamycin D / mureidomycin A / mureidomycin B	NRP:Uridylpeptide + Other:Nucleoside	75%

BGC0000951 - Region 1 - NRPS,NRPS-like

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Location: 1 - 30,311 nt. (total: 30,311 nt) Show pHMM detection rules used

Region on contig edge.

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))
NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 30,312
Label		BGC0000951

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000951.1	1.77	NRP	pacidamycin 1, pacidamycin 2, pacidamycin 3, pacidamycin 4, pacidamycin 5, pacidamycin 6, pacidamycin 7, pacidamycin D	Streptomyces coeruleorubidus
BGC0000375.1	0.69	NRP	indigoidine	Streptomyces chromofuscus
BGC0000427.1	0.68	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0000465.1	0.66	NRP	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061
BGC0001249.1	0.64	NRP	dimethylcoprogen	Alternaria alternata
BGC0000900.1	0.64	Other	ferrichrome	Aspergillus oryzae
BGC0000921.1	0.58	Other, Polyketide, NRP, , (, S, h, i, k, i, m, a, t, e, -, d, e, r, i, v, e, d, )	promysalin	Pseudomonas putida
BGC0000876.1	0.57	Other	neopolyoxin C	Streptomyces tendae
BGC0001479.1	0.56	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0001718.1	0.55	NRP	okaramine D	Aspergillus aculeatus ATCC 16872

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000951.1	0.96	NRP	pacidamycin 1, pacidamycin 2, pacidamycin 3, pacidamycin 4, pacidamycin 5, pacidamycin 6, pacidamycin 7, pacidamycin D	Streptomyces coeruleorubidus
BGC0000375.1	0.67	NRP	indigoidine	Streptomyces chromofuscus
BGC0000427.1	0.67	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0000465.1	0.66	NRP	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061
BGC0001249.1	0.65	NRP	dimethylcoprogen	Alternaria alternata
BGC0000900.1	0.65	Other	ferrichrome	Aspergillus oryzae
BGC0000921.1	0.63	Other, Polyketide, NRP, , (, S, h, i, k, i, m, a, t, e, -, d, e, r, i, v, e, d, )	promysalin	Pseudomonas putida
BGC0000876.1	0.62	Other	neopolyoxin C	Streptomyces tendae
BGC0001479.1	0.62	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0001718.1	0.61	NRP	okaramine D	Aspergillus aculeatus ATCC 16872

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 30311:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

pacL

Search NORINE for peptide: strict or relaxed

AMP-binding (278..677): X

NRPSPredictor2: hydrophobic-aliphatic

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DpgIyGqLaK
Nearest Stachelhaus code:: lys-b
Stachelhaus code match:: 50% (weak)

pacO

Search NORINE for peptide: strict or relaxed

AMP-binding (23..425): X

NRPSPredictor2: gly, ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: gly, ala
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DLssVGvcyK
Nearest Stachelhaus code:: asp
Stachelhaus code match:: 50% (weak)

pacP

Search NORINE for peptide: strict or relaxed

AMP-binding (30..426): X

NRPSPredictor2: (unknown)

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DiWQgtadDK
Nearest Stachelhaus code:: gln
Stachelhaus code match:: 50% (weak)

pacU

Search NORINE for peptide: strict or relaxed

AMP-binding (13..412): X

NRPSPredictor2: hydrophobic-aliphatic

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DchyFaLItK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 50% (weak)