BGC0001193 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001193 (Saccharothrix algeriensis)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	41,334	holomycin	NRP	53%

BGC0001193 - Region 1 - NRPS

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Location: 1 - 41,334 nt. (total: 41,334 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 41,335
Label		BGC0001193

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001193.1	1.00	NRP	thiolutin	Saccharothrix algeriensis
BGC0000426.1	0.30	NRP	sevadicin	Paenibacillus larvae
BGC0001538.1	0.30	NRP, Polyketide	caboxamycin	Streptomyces sp. NTK 937
BGC0000003.1	0.29	Polyketide	AF-toxin	Alternaria alternata
BGC0000653.1	0.29	Terpene	pentalenolactone	Streptomyces arenae
BGC0000373.1	0.28	NRP	holomycin	Streptomyces clavuligerus ATCC 27064
BGC0001197.1	0.28	Polyketide	frankiamicin	Frankia sp. EAN1pec
BGC0000347.1	0.27	NRP	equibactin	Streptococcus equi subsp. equi
BGC0000935.1	0.27	Other, Polyketide, , (, A, m, i, n, o, c, o, u, m, a, r, i, n, )	esmeraldin	Streptomyces antibioticus
BGC0000389.1	0.27	NRP	massetolide A	Pseudomonas fluorescens SS101

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001193.1	1.00	NRP	thiolutin	Saccharothrix algeriensis
BGC0000426.1	0.64	NRP	sevadicin	Paenibacillus larvae
BGC0001538.1	0.63	NRP, Polyketide	caboxamycin	Streptomyces sp. NTK 937
BGC0000003.1	0.63	Polyketide	AF-toxin	Alternaria alternata
BGC0000653.1	0.63	Terpene	pentalenolactone	Streptomyces arenae
BGC0000373.1	0.62	NRP	holomycin	Streptomyces clavuligerus ATCC 27064
BGC0001197.1	0.61	Polyketide	frankiamicin	Frankia sp. EAN1pec
BGC0000347.1	0.61	NRP	equibactin	Streptococcus equi subsp. equi
BGC0000935.1	0.61	Other, Polyketide, , (, A, m, i, n, o, c, o, u, m, a, r, i, n, )	esmeraldin	Streptomyces antibioticus
BGC0000389.1	0.61	NRP	massetolide A	Pseudomonas fluorescens SS101

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 39384:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-X) + (cys) + (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

AJI44167.1

Search NORINE for peptide: strict or relaxed

AMP-binding (245..632): X

NRPSPredictor2: hydrophilic

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVwnVGAInK
Nearest Stachelhaus code:: arg
Stachelhaus code match:: 70% (weak)

dtpB

Search NORINE for peptide: strict or relaxed

AMP-binding (455..855): cys

NRPSPredictor2: cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: cys
Small clusters prediction:: cys
Single AA prediction:: cys

Stachelhaus prediction details:

Stachelhaus sequence:: DLYNLSLIWK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 100% (strong)

AJI44189.1

PKS_AT (7..296): mal

ATSignature: Propionyl-CoA, Malonyl-CoA

Top 3 matches:: Propionyl-CoA: 58.3%; Malonyl-CoA: 58.3%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 57.9
Methylmalonyl-CoA: 47.4
Methoxymalonyl-CoA: 42.4
fatty_acid: 30.8
CHC-CoA: 25.3
Ethylmalonyl-CoA: 16.1
Benzoyl-CoA: 15.1
2-Methylbutyryl-CoA: 11.5
Propionyl-CoA: 8.2
Isobutyryl-CoA: 3.8
trans-1,2-CPDA: 0.0
inactive: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0