BGC0001381 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001381 (Nocardia terpenica (Nocardia brasiliensis IFM 0406))

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS-like,T1PKS	1	210,303	caniferolide A / caniferolide B / caniferolide C / caniferolide D	Polyketide:Modular type I	22%

BGC0001381 - Region 1 - NRPS-like,T1PKS

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Location: 1 - 210,303 nt. (total: 210,303 nt) Show pHMM detection rules used

Region on contig edge.

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 210,304
Label		BGC0001381

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000876.1	0.44	Other	neopolyoxin C	Streptomyces tendae
BGC0000145.1	0.43	Polyketide	salinosporamide A	Salinispora tropica
BGC0001041.1	0.42	NRP, Polyketide	salinosporamide A	Salinispora tropica CNB-440
BGC0000823.1	0.40	Alkaloid	rebeccamycin	Lechevalieria aerocolonigenes
BGC0001793.1	0.40	Polyketide	swainsonine	Chaetothyriaceae sp.
BGC0001794.1	0.39	Polyketide	swainsonine	Alternaria oxytropis
BGC0000632.1	0.39	Terpene, Saccharide	brasilicardin A	Nocardia terpenica
BGC0000220.1	0.39	Polyketide	enterocin	Streptomyces maritimus
BGC0000821.1	0.38	Other, , (, A, m, i, n, o, c, o, u, m, a, r, i, n, )	rebeccamycin	Lechevalieria aerocolonigenes
BGC0001012.1	0.38	NRP, Polyketide	meridamycin	Streptomyces violaceusniger

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000375.1	0.67	NRP	indigoidine	Streptomyces chromofuscus
BGC0001273.1	0.67	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001012.1	0.67	NRP, Polyketide	meridamycin	Streptomyces violaceusniger
BGC0001276.1	0.67	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.1	0.66	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001275.1	0.66	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0000201.1	0.66	Polyketide, Saccharide	auricin	Streptomyces aureofaciens
BGC0000427.1	0.66	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0001735.1	0.66	Other	pentostatine, vidarabine	Streptomyces antibioticus
BGC0000160.1	0.65	Polyketide	terreic acid	Aspergillus terreus NIH2624

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 164387:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ohmal - ohmal) + (ohmal - redmal) + (ohmal - Me-ohmal - ohmal - ccmal) + (ohmal - ohmal - mal - Me-ohmal - redmal) + (Me-ohmal - Me-ohmal - ccmal) + (Me-mal - Me-ohmal - Me-ohmal) + (tyr) + (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 0 - 29877:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (tyr) + (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 27332 - 164387:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (tyr) + (Me-mal - Me-ohmal - Me-ohmal) + (Me-ohmal - Me-ohmal - ccmal) + (ohmal - ohmal - mal - Me-ohmal - redmal) + (ohmal - Me-ohmal - ohmal - ccmal) + (ohmal - redmal) + (ohmal - ohmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

AJO72702.1

Search NORINE for peptide: strict or relaxed

AMP-binding (78..503): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: vmaQvGL--K
Nearest Stachelhaus code:: gln
Stachelhaus code match:: 40% (weak)

AJO72717.1

Search NORINE for peptide: strict or relaxed

AMP-binding (430..827): tyr

NRPSPredictor2: tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: asp, asn
Single AA prediction:: tyr

Stachelhaus prediction details:

Stachelhaus sequence:: DvTtIiEVGK
Nearest Stachelhaus code:: asn
Stachelhaus code match:: 70% (weak)

nbrQ1

Search NORINE for peptide: strict or relaxed

AMP-binding (98..322): X

NRPSPredictor2: hydrophobic-aliphatic

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: ---v---IkK
Nearest Stachelhaus code:: ala
Stachelhaus code match:: 20% (weak)

nbrK

PKS_AT (602..904): mmal

ATSignature: Malonyl-CoA, Methylmalonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; Methylmalonyl-CoA: 79.2%; Methoxymalonyl-CoA: 70.8%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 152.4
Ethylmalonyl-CoA: 127.1
Methoxymalonyl-CoA: 123.0
Malonyl-CoA: 97.8
Propionyl-CoA: 66.5
2-Methylbutyryl-CoA: 66.0
Isobutyryl-CoA: 60.2
CHC-CoA: 44.4
trans-1,2-CPDA: 43.7
Benzoyl-CoA: 38.6
inactive: 35.9
Acetyl-CoA: 24.5
3-Methylbutyryl-CoA: 23.2
fatty_acid: 9.1

PKS_AT (1605..1895): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 91.7%; Malonyl-CoA: 83.3%; Methoxymalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 155.7
Ethylmalonyl-CoA: 131.6
Methoxymalonyl-CoA: 129.7
Propionyl-CoA: 77.6
2-Methylbutyryl-CoA: 75.7
trans-1,2-CPDA: 66.5
Malonyl-CoA: 63.1
CHC-CoA: 43.9
Isobutyryl-CoA: 36.6
Benzoyl-CoA: 36.2
fatty_acid: 30.4
inactive: 24.8
Acetyl-CoA: 21.0
3-Methylbutyryl-CoA: 11.4

PKS_AT (3219..3509): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 91.7%; Malonyl-CoA: 83.3%; Methoxymalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 151.1
Ethylmalonyl-CoA: 132.9
Methoxymalonyl-CoA: 125.2
Propionyl-CoA: 73.9
2-Methylbutyryl-CoA: 72.2
trans-1,2-CPDA: 67.9
Malonyl-CoA: 67.9
CHC-CoA: 54.2
Isobutyryl-CoA: 39.0
Benzoyl-CoA: 37.2
fatty_acid: 33.9
inactive: 25.1
Acetyl-CoA: 17.0
3-Methylbutyryl-CoA: 11.3

nbrL

PKS_AT (558..856): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 91.7%; Malonyl-CoA: 83.3%; Methoxymalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 177.8
Ethylmalonyl-CoA: 161.3
Methoxymalonyl-CoA: 141.8
2-Methylbutyryl-CoA: 108.0
trans-1,2-CPDA: 96.0
Malonyl-CoA: 85.7
Propionyl-CoA: 77.6
CHC-CoA: 64.1
Isobutyryl-CoA: 50.3
Benzoyl-CoA: 41.3
3-Methylbutyryl-CoA: 29.2
fatty_acid: 26.9
Acetyl-CoA: 21.1
inactive: 20.1

PKS_AT (2092..2390): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 83.3%; Methoxymalonyl-CoA: 79.2%; Malonyl-CoA: 75.0%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 157.7
Ethylmalonyl-CoA: 133.4
Methoxymalonyl-CoA: 123.3
Malonyl-CoA: 93.3
2-Methylbutyryl-CoA: 66.4
CHC-CoA: 63.4
Propionyl-CoA: 63.2
trans-1,2-CPDA: 62.5
Isobutyryl-CoA: 33.1
Benzoyl-CoA: 26.6
inactive: 21.8
fatty_acid: 20.0
Acetyl-CoA: 17.7
3-Methylbutyryl-CoA: 12.1

PKS_AT (3648..3925): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 83.3%; inactive: 66.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 119.4
Methylmalonyl-CoA: 53.9
Methoxymalonyl-CoA: 45.1
Propionyl-CoA: 29.0
Ethylmalonyl-CoA: 27.7
CHC-CoA: 24.1
inactive: 21.7
2-Methylbutyryl-CoA: 19.0
trans-1,2-CPDA: 18.1
Benzoyl-CoA: 13.3
Acetyl-CoA: 12.5
fatty_acid: 10.6
Isobutyryl-CoA: 10.4
3-Methylbutyryl-CoA: 0.0

nbrG

PKS_AT (585..873): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 66.7%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 129.4
Methoxymalonyl-CoA: 67.7
Methylmalonyl-CoA: 65.6
inactive: 51.5
Ethylmalonyl-CoA: 48.6
Propionyl-CoA: 43.1
2-Methylbutyryl-CoA: 29.0
CHC-CoA: 26.3
trans-1,2-CPDA: 21.1
Acetyl-CoA: 12.0
Benzoyl-CoA: 11.7
fatty_acid: 8.2
Isobutyryl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2077..2354): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 62.5%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 134.0
Methoxymalonyl-CoA: 66.8
Methylmalonyl-CoA: 64.5
Propionyl-CoA: 46.9
inactive: 45.1
Ethylmalonyl-CoA: 37.0
CHC-CoA: 26.7
2-Methylbutyryl-CoA: 17.1
fatty_acid: 13.2
Isobutyryl-CoA: 12.7
Acetyl-CoA: 11.2
Benzoyl-CoA: 7.8
3-Methylbutyryl-CoA: 0.0
trans-1,2-CPDA: -2.4

PKS_AT (3574..3875): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 180.1
Methoxymalonyl-CoA: 67.8
Methylmalonyl-CoA: 59.9
inactive: 57.0
Benzoyl-CoA: 36.9
Isobutyryl-CoA: 34.0
CHC-CoA: 33.1
Ethylmalonyl-CoA: 31.3
Propionyl-CoA: 29.7
Acetyl-CoA: 27.6
fatty_acid: 23.3
2-Methylbutyryl-CoA: 21.8
trans-1,2-CPDA: 17.4
3-Methylbutyryl-CoA: 8.7

PKS_AT (5012..5313): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Malonyl-CoA: 87.5%; Methoxymalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 184.2
Ethylmalonyl-CoA: 166.4
Methoxymalonyl-CoA: 145.9
2-Methylbutyryl-CoA: 109.6
trans-1,2-CPDA: 97.3
Malonyl-CoA: 94.2
Benzoyl-CoA: 76.2
Propionyl-CoA: 74.1
Isobutyryl-CoA: 62.1
CHC-CoA: 57.0
inactive: 40.3
fatty_acid: 26.8
Acetyl-CoA: 23.4
3-Methylbutyryl-CoA: 19.1

PKS_AT (6570..6853): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 179.4
inactive: 98.5
Methylmalonyl-CoA: 53.8
Methoxymalonyl-CoA: 52.0
Propionyl-CoA: 31.2
Ethylmalonyl-CoA: 25.7
fatty_acid: 21.1
Benzoyl-CoA: 19.5
Isobutyryl-CoA: 18.0
trans-1,2-CPDA: 17.0
CHC-CoA: 13.6
2-Methylbutyryl-CoA: 12.3
Acetyl-CoA: 11.9
3-Methylbutyryl-CoA: 0.0

nbrH

PKS_AT (563..856): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 79.2%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 180.3
inactive: 95.9
Methoxymalonyl-CoA: 69.6
Methylmalonyl-CoA: 59.3
Ethylmalonyl-CoA: 33.4
CHC-CoA: 33.4
Isobutyryl-CoA: 32.2
Propionyl-CoA: 29.4
Benzoyl-CoA: 25.8
Acetyl-CoA: 19.6
2-Methylbutyryl-CoA: 19.3
trans-1,2-CPDA: 15.4
fatty_acid: 9.1
3-Methylbutyryl-CoA: 0.0

PKS_AT (2089..2393): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 83.3%; Malonyl-CoA: 79.2%; Methoxymalonyl-CoA: 75.0%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 170.4
Ethylmalonyl-CoA: 153.3
Methoxymalonyl-CoA: 146.8
Malonyl-CoA: 95.9
trans-1,2-CPDA: 89.0
2-Methylbutyryl-CoA: 80.1
Propionyl-CoA: 71.4
Isobutyryl-CoA: 69.2
CHC-CoA: 57.1
Benzoyl-CoA: 54.8
Acetyl-CoA: 52.7
fatty_acid: 34.5
3-Methylbutyryl-CoA: 26.0
inactive: 22.9

PKS_AT (3652..3937): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 170.6
inactive: 88.4
Methylmalonyl-CoA: 50.7
Methoxymalonyl-CoA: 48.8
Propionyl-CoA: 24.0
Isobutyryl-CoA: 18.9
Benzoyl-CoA: 16.1
Ethylmalonyl-CoA: 13.4
fatty_acid: 11.9
CHC-CoA: 11.5
Acetyl-CoA: 8.9
2-Methylbutyryl-CoA: 6.7
trans-1,2-CPDA: 5.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (5186..5499): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%; 2-Methylbutyryl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 154.7
inactive: 90.7
Methoxymalonyl-CoA: 58.8
Methylmalonyl-CoA: 51.2
Propionyl-CoA: 33.0
Ethylmalonyl-CoA: 27.8
CHC-CoA: 25.5
trans-1,2-CPDA: 18.0
Benzoyl-CoA: 16.2
fatty_acid: 11.1
Acetyl-CoA: 9.2
2-Methylbutyryl-CoA: 7.8
Isobutyryl-CoA: 7.1
3-Methylbutyryl-CoA: 0.0

nbrI

PKS_AT (570..842): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 62.5%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 144.6
Methylmalonyl-CoA: 66.3
Methoxymalonyl-CoA: 63.8
inactive: 53.6
Propionyl-CoA: 40.8
Ethylmalonyl-CoA: 31.8
CHC-CoA: 28.7
2-Methylbutyryl-CoA: 23.7
Isobutyryl-CoA: 20.8
trans-1,2-CPDA: 20.4
fatty_acid: 17.1
Acetyl-CoA: 16.3
Benzoyl-CoA: 12.7
3-Methylbutyryl-CoA: 0.7

PKS_AT (2086..2371): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 66.7%; Propionyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 168.7
inactive: 78.4
Methoxymalonyl-CoA: 42.0
Methylmalonyl-CoA: 41.8
Isobutyryl-CoA: 26.4
Acetyl-CoA: 14.9
Ethylmalonyl-CoA: 14.4
Propionyl-CoA: 11.5
CHC-CoA: 7.9
fatty_acid: 5.4
Benzoyl-CoA: 3.7
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

nbrJ

PKS_AT (553..835): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 66.7%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 123.1
Methoxymalonyl-CoA: 69.5
Methylmalonyl-CoA: 66.2
inactive: 43.8
Ethylmalonyl-CoA: 39.9
Propionyl-CoA: 28.9
CHC-CoA: 27.1
Isobutyryl-CoA: 26.9
trans-1,2-CPDA: 17.4
2-Methylbutyryl-CoA: 15.8
Benzoyl-CoA: 15.2
fatty_acid: 14.3
Acetyl-CoA: 8.1
3-Methylbutyryl-CoA: 6.9

PKS_AT (1944..2225): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 66.7%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 128.7
Methoxymalonyl-CoA: 56.4
inactive: 49.4
Methylmalonyl-CoA: 48.2
Ethylmalonyl-CoA: 24.2
fatty_acid: 21.4
Isobutyryl-CoA: 19.6
CHC-CoA: 15.5
trans-1,2-CPDA: 13.0
Propionyl-CoA: 12.0
Benzoyl-CoA: 11.2
Acetyl-CoA: 9.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: -0.9