BGC0001788 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001788 (Streptococcus suis)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	lanthipeptide-class-ii	1	11,509	streptococcin A-FF22	RiPP:Lanthipeptide	80%

BGC0001788 - Region 1 - lanthipeptide-class-ii

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Location: 1 - 11,509 nt. (total: 11,509 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

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Gene details

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MIBiG

MIBiG comparison

KnownClusterBlast

Lanthipeptides

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 11,510
Label		BGC0001788

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001788.1	1.00	RiPP	suicin 65	Streptococcus suis
BGC0000526.1	0.53	RiPP	macedocin	Streptococcus macedonicus
BGC0000557.1	0.48	RiPP	streptococcin A-FF22	Streptococcus pyogenes
BGC0000547.1	0.38	RiPP	salivaricin 9	Streptococcus salivarius
BGC0000550.1	0.36	RiPP	salivaricin G32	Streptococcus salivarius
BGC0000528.1	0.36	RiPP	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001787.1	0.36	RiPP	suicin 3908	Streptococcus suis
BGC0000626.1	0.36	RiPP	thuricin	Bacillus thuringiensis
BGC0000498.1	0.34	RiPP	bovicin HJ50	Streptococcus equinus
BGC0000561.1	0.34	RiPP	thermophilin 1277	Streptococcus thermophilus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001788.1	1.00	RiPP	suicin 65	Streptococcus suis
BGC0000526.1	0.80	RiPP	macedocin	Streptococcus macedonicus
BGC0000557.1	0.77	RiPP	streptococcin A-FF22	Streptococcus pyogenes
BGC0000547.1	0.71	RiPP	salivaricin 9	Streptococcus salivarius
BGC0000550.1	0.69	RiPP	salivaricin G32	Streptococcus salivarius
BGC0000528.1	0.69	RiPP	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001787.1	0.69	RiPP	suicin 3908	Streptococcus suis
BGC0000626.1	0.69	RiPP	thuricin	Bacillus thuringiensis
BGC0000498.1	0.67	RiPP	bovicin HJ50	Streptococcus equinus
BGC0000561.1	0.67	RiPP	thermophilin 1277	Streptococcus thermophilus

Similar known gene clusters

Lanthipeptide predictions

Lanthipeptide(s) for sssM

sssA

Leader:

MKDNYELMNTIQEVSLEELDQIIGA

sssA_

Leader:

MKKDIELMSTIQEVSLEELDQIIGA

Shared core:

GKNGVFKTISHECHMNSWQFLFTCCS

Core with dehydrations:

GKNGVFKDhbIDhaHECysHMNDhaWQFLFDhbCysCysDha

sssA1

Leader:

MNAKTNKEINYEAVATLQEVKIDDLDILLGG

Core:

AGHGVNTISAECRWNSLQAIFTCC

Core with dehydrations:

AGHGVNDhbIDhaAECysRWNDhaLQAIFDhbCysCys

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

sssA - Class II

Cleavage pHMM score: 5.20

RODEO score: 0

Monoisotopic mass: 2913.3 Da

Molecular weight: 2915.3 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2933.4 Da N = 1; 2951.4 Da N = 2

sssA_ - Class II

Cleavage pHMM score: 5.20

RODEO score: 0

Monoisotopic mass: 2913.3 Da

Molecular weight: 2915.3 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2933.4 Da N = 1; 2951.4 Da N = 2

sssA1 - Class II

Cleavage pHMM score: -3.80

RODEO score: 0

Monoisotopic mass: 2508.2 Da

Molecular weight: 2509.8 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2527.8 Da N = 1