BGC0000038 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000038 (Streptomyces coelicolor A3(2))

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS,butyrolactone	1	57,887	coelimycin P1	PKS:Type I	100%

BGC0000038 - Region 1 - T1PKS,butyrolactone

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Location: 1 - 57,887 nt. (total: 57,887 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
butyrolactone: AfsA

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 57,888
Label		BGC0000038

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000849	2.00	Other (Butyrolactone)	SCB1, SCB2, SCB3	Streptomyces coelicolor A3(2)
BGC0000038	1.17	Polyketide	coelimycin P1	Streptomyces coelicolor A3(2)
BGC0000848	0.86	Other	A-factor	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000850	0.72	Other	γ-butyrolactone	Streptomyces acidiscabies
BGC0000234	0.41	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0002578	0.37	Other	gaburedin A, gaburedin B, gaburedin C, gaburedin D, gaburedin E, gaburedin F	Streptomyces venezuelae ATCC 10712
BGC0000131	0.37	Polyketide	pyrrolomycin	Streptomyces sp. UC 11065
BGC0000016	0.36	Other	amphotericin B	Streptomyces nodosus
BGC0001596	0.34	Polyketide	fluostatins M-Q	Streptomyces albus
BGC0001458	0.34	Other (Aminocoumarin)	salinipostin G	Salinispora tropica CNB-440

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000038	1.00	Polyketide	coelimycin P1	Streptomyces coelicolor A3(2)
BGC0000849	1.00	Other (Butyrolactone)	SCB1, SCB2, SCB3	Streptomyces coelicolor A3(2)
BGC0000848	0.74	Other	A-factor	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000234	0.73	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000016	0.69	Other	amphotericin B	Streptomyces nodosus
BGC0000850	0.69	Other	γ-butyrolactone	Streptomyces acidiscabies
BGC0001596	0.67	Polyketide	fluostatins M-Q	Streptomyces albus
BGC0000236	0.66	Polyketide	kinamycin	Streptomyces murayamaensis
BGC0000866	0.66	Other	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0000919	0.66	Other	phaseolotoxin	Pseudomonas syringae

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 57887:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - ccmal - ccmal) + (ccmal - ccmal) + (ccmal)
Non-colinear ordering:: SCO6275 + SCO6274 + SCO6273

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

SCO6273

PKS_AT (565..854): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 171.9
inactive: 73.8
Methoxymalonyl-CoA: 62.1
Methylmalonyl-CoA: 40.8
Propionyl-CoA: 29.3
Acetyl-CoA: 18.6
Isobutyryl-CoA: 15.6
2-Methylbutyryl-CoA: 14.1
Benzoyl-CoA: 9.6
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

SCO6274

PKS_AT (578..871): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 171.9
inactive: 73.8
Methoxymalonyl-CoA: 62.1
Methylmalonyl-CoA: 40.8
Propionyl-CoA: 29.3
Acetyl-CoA: 18.6
Isobutyryl-CoA: 15.6
2-Methylbutyryl-CoA: 14.1
Benzoyl-CoA: 9.6
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2332..2621): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 171.9
inactive: 73.8
Methoxymalonyl-CoA: 62.1
Methylmalonyl-CoA: 40.8
Propionyl-CoA: 29.3
Acetyl-CoA: 18.6
Isobutyryl-CoA: 15.6
2-Methylbutyryl-CoA: 14.1
Benzoyl-CoA: 9.6
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

SCO6275

PKS_AT (548..829): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 209.2
inactive: 103.5
Methoxymalonyl-CoA: 75.4
Methylmalonyl-CoA: 68.4
Isobutyryl-CoA: 37.8
2-Methylbutyryl-CoA: 31.3
Benzoyl-CoA: 30.9
Acetyl-CoA: 30.9
Propionyl-CoA: 29.8
Ethylmalonyl-CoA: 28.1
fatty_acid: 20.5
CHC-CoA: 16.6
3-Methylbutyryl-CoA: 15.4
trans-1,2-CPDA: 15.0

PKS_AT (1549..1846): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 203.5
inactive: 97.1
Methoxymalonyl-CoA: 72.9
Methylmalonyl-CoA: 61.7
Isobutyryl-CoA: 41.7
Propionyl-CoA: 30.9
Ethylmalonyl-CoA: 16.8
Acetyl-CoA: 16.8
2-Methylbutyryl-CoA: 14.2
Benzoyl-CoA: 13.3
3-Methylbutyryl-CoA: 9.0
fatty_acid: 8.4
CHC-CoA: 3.9
trans-1,2-CPDA: 0.0

PKS_AT (3286..3585): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 207.6
inactive: 105.9
Methoxymalonyl-CoA: 62.0
Methylmalonyl-CoA: 50.9
Propionyl-CoA: 30.8
Ethylmalonyl-CoA: 17.7
Isobutyryl-CoA: 16.7
2-Methylbutyryl-CoA: 15.7
Acetyl-CoA: 15.4
Benzoyl-CoA: 11.6
CHC-CoA: 9.5
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0