BGC0000130 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000130 (Streptomyces vitaminophilus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	55,655	marinopyrrole A / marinopyrrole E / marinopyrrole D / marinopyrrole C / marinopyrrole B	NRP + Polyketide:Modular type I	52%

BGC0000130 - Region 1 - T1PKS

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Location: 1 - 55,655 nt. (total: 55,655 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 55,656
Label		BGC0000130

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000130.1	0.60	Polyketide	pyrrolomycin A, pyrrolomycin B, pyrrolomycin C, pyrrolomycin D	Streptomyces vitaminophilus
BGC0000132.1	0.32	Polyketide	pyrrolomycin	Streptomyces sp. UC 11065
BGC0001280.1	0.30	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0001264.1	0.30	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0000041.1	0.30	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000924.1	0.29	Other	pyrrolnitrin	Pseudomonas chlororaphis
BGC0001858.1	0.28	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0001335.1	0.28	Alkaloid	borregomycin A, borregomycin B, borregomycin C, borregomycin D	uncultured bacterium
BGC0001333.1	0.26	Alkaloid	BE-54017	uncultured bacterium AB1650
BGC0001337.1	0.26	Alkaloid	lazarimide A, lazarimide B, lazarimide C	uncultured bacterium

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000130.1	0.87	Polyketide	pyrrolomycin A, pyrrolomycin B, pyrrolomycin C, pyrrolomycin D	Streptomyces vitaminophilus
BGC0000131.1	0.78	Polyketide	pyrrolomycin	Streptomyces sp. UC 11065
BGC0000132.1	0.65	Polyketide	pyrrolomycin	Streptomyces sp. UC 11065
BGC0001280.1	0.63	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0001264.1	0.63	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0000041.1	0.63	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000924.1	0.63	Other	pyrrolnitrin	Pseudomonas chlororaphis
BGC0001858.1	0.62	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0000046.1	0.61	Polyketide	depudecin	Alternaria brassicicola
BGC0001778.1	0.60	Other	showdomycin	Streptomyces showdoensis

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 10892 - 55655:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal) + (ccmal)
Non-colinear ordering:: pyr25 + pyr24

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

pyr8

Search NORINE for peptide: strict or relaxed

AMP-binding (6..373): X

NRPSPredictor2: gly, ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: gly, ala
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DLfYiAwV-K
Nearest Stachelhaus code:: iva
Stachelhaus code match:: 60% (weak)

pyr24

PKS_AT (572..866): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 87.5%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 199.4
inactive: 115.0
Methoxymalonyl-CoA: 74.5
Methylmalonyl-CoA: 74.4
Propionyl-CoA: 48.9
Isobutyryl-CoA: 48.1
Ethylmalonyl-CoA: 38.1
CHC-CoA: 27.2
2-Methylbutyryl-CoA: 26.2
Benzoyl-CoA: 24.3
Acetyl-CoA: 18.1
fatty_acid: 12.5
trans-1,2-CPDA: 12.0
3-Methylbutyryl-CoA: 0.0

pyr25

PKS_AT (563..858): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; Methylmalonyl-CoA: 79.2%; Ethylmalonyl-CoA: 66.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 132.4
Methylmalonyl-CoA: 131.3
Methoxymalonyl-CoA: 105.5
Ethylmalonyl-CoA: 91.1
Isobutyryl-CoA: 76.4
Propionyl-CoA: 73.7
2-Methylbutyryl-CoA: 61.5
Benzoyl-CoA: 53.7
inactive: 52.6
Acetyl-CoA: 52.5
trans-1,2-CPDA: 50.3
fatty_acid: 47.1
CHC-CoA: 46.9
3-Methylbutyryl-CoA: 21.6