BGC0000194 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000194 (Streptomyces coelicolor A3(2))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	72,624	High	actinorhodin	PKS:Type II aromatic

BGC0000194 - Region 1 - T2PKS

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Location: 1 - 72,624 nt. (total: 72,624 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 72,625
Label		BGC0000194

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

SCO5072: 3-hydroxybutyryl-CoA dehydrogenase

smcogs: SMCOG1095: 3-hydroxybutyryl-CoA dehydrogenase

SCO5073: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

SCO5075: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

SCO5080: acyl-CoA dehydrogenase type 2

smcogs: SMCOG1191: acyl-CoA dehydrogenase type 2

SCO5086: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

SCO5092: flavin reductase domain protein FMN-binding

smcogs: SMCOG1160: flavin reductase domain protein FMN-binding

Hydrolases: hydrolase

SCO5091: metallo-beta-lactamase family protein

smcogs: SMCOG1170: metallo-beta-lactamase family protein

Lyases: cyclase

SCO5090: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

Ligases: synthase

SCO5087: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

SCO5088: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Translocases: transport

SCO5084: MMPL domain-containing transport protein

smcogs: SMCOG1035: MMPL domain-containing transport protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000194.5	1.00	PKS	actinorhodin	Streptomyces coelicolor A3(2)
BGC0000231.5	0.69	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000272.3	0.64	PKS	spore pigment	Streptomyces collinus
BGC0002276.2	0.59	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000275.4	0.59	PKS	tetracenomycin C	Streptomyces glaucescens
BGC0001723.5	0.57	PKS	oviedomycin	Streptomyces antibioticus
BGC0001197.5	0.56	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000234.5	0.56	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000271.5	0.56	PKS	spore pigment	Streptomyces avermitilis
BGC0002477.3	0.55	PKS	thioangucycline A, thioangucycline B	Streptomyces sp. CB00072

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000194.5	1.00	PKS	actinorhodin	Streptomyces coelicolor A3(2)
BGC0000231.5	0.69	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000272.3	0.64	PKS	spore pigment	Streptomyces collinus
BGC0002276.2	0.59	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000275.4	0.59	PKS	tetracenomycin C	Streptomyces glaucescens
BGC0001723.5	0.57	PKS	oviedomycin	Streptomyces antibioticus
BGC0001197.5	0.56	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000234.5	0.56	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000271.5	0.56	PKS	spore pigment	Streptomyces avermitilis
BGC0002477.3	0.55	PKS	thioangucycline A, thioangucycline B	Streptomyces sp. CB00072

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

Type II PKS

Type II PKS gene cluster prediction details

Cluster section:: 0 to 72624
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)
Malonyl elongations:: 7 (Score: 743.5; E-value: 1.2e-226)
Product class(es):: benzoisochromanequinone
Product molecular weight(s):: acetyl-CoA_7: 325 Da

SCO5072: KR (Score: 159.4; E-value: 3.1e-49)
SCO5079: DIMER (Score: 426.8; E-value: 8.7e-131)
SCO5080: OXY (Score: 44.7; E-value: 2.1e-14)
SCO5086: KR C9 (Score: 438.4; E-value: 1.9e-134)
SCO5087: KS (Score: 768.6; E-value: 3.5e-234)
SCO5088: CLF 7 (Score: 743.5; E-value: 1.2e-226)
SCO5089: ACP (Score: 114.2; E-value: 5e-36)
SCO5090: CYC C7-C12 (Score: 404.0; E-value: 7.8e-124)
SCO5091: CYC C5-C14 (Score: 467.3; E-value: 4.4e-143)