BGC0001195 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001195 (Nocardiopsis sp. CMB-M0232)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS,NRPS	1	76,702	lydicamycin	NRP + Polyketide:Modular type I	32%

BGC0001195 - Region 1 - NRPS,T1PKS

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Location: 1 - 76,702 nt. (total: 76,702 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 76,703
Label		BGC0001195

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001195.1	1.40	NRP, Polyketide	nocardiopsin A, nocardiopsin B, nocardiopsin C, nocardiopsin D	Nocardiopsis sp. CMB-M0232
BGC0000457.1	0.63	NRP	vicibactin	Rhizobium etli CFN 42
BGC0000041.1	0.60	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0002058.1	0.58	Other	Reutericyclin A, Reutericyclin B, Reutericyclin C, Reutericyclin D	Streptococcus mutans B04Sm5
BGC0000417.1	0.55	NRP	rhodochelin	Rhodococcus jostii RHA1
BGC0000342.1	0.55	NRP	enniatin	Fusarium equiseti
BGC0001913.1	0.54	Polyketide	phomoidride	fungal sp. ATCC 74256
BGC0000292.1	0.54	NRP	acetylaranotin	Aspergillus terreus NIH2624
BGC0000313.1	0.53	NRP	beauvericin	Beauveria bassiana
BGC0001197.1	0.52	Polyketide	frankiamicin	Frankia sp. EAN1pec

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001195.1	0.96	NRP, Polyketide	nocardiopsin A, nocardiopsin B, nocardiopsin C, nocardiopsin D	Nocardiopsis sp. CMB-M0232
BGC0000067.1	0.69	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000041.1	0.67	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000457.1	0.66	NRP	vicibactin	Rhizobium etli CFN 42
BGC0001854.1	0.64	Polyketide	tricholignan A	Trichoderma harzianum
BGC0001901.1	0.64	Polyketide	tricholignan A	Trichoderma harzianum
BGC0000160.1	0.63	Polyketide	terreic acid	Aspergillus terreus NIH2624
BGC0000120.1	0.63	Polyketide	patulin	Penicillium expansum
BGC0001578.1	0.63	Polyketide	duclauxin	Talaromyces stipitatus ATCC 10500
BGC0001304.1	0.63	Polyketide	aflavarin	Aspergillus flavus NRRL3357

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 76702:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pip) + (Me-mal - ohmal - Me-ccmal - Me-redmal) + (ohmal - ohmal - redmal) + (Me-ccmal - Me-mal - redmal) + (ccmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 0 - 36304:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pip) + (Me-mal - ohmal - Me-ccmal - Me-redmal) + (ohmal - ohmal - redmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

AJW65406.1

Search NORINE for peptide: strict or relaxed

AMP-binding (501..903): pip

NRPSPredictor2: pip

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: pro, pip
Small clusters prediction:: pro
Single AA prediction:: pro

Stachelhaus prediction details:

Stachelhaus sequence:: DIQFSAHVVK
Nearest Stachelhaus code:: pip
Stachelhaus code match:: 100% (strong)

AJW65407.1

PKS_AT (550..844): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 194.6
Ethylmalonyl-CoA: 193.3
Methoxymalonyl-CoA: 149.5
2-Methylbutyryl-CoA: 128.0
Propionyl-CoA: 104.1
CHC-CoA: 101.0
trans-1,2-CPDA: 97.9
Malonyl-CoA: 95.7
Isobutyryl-CoA: 49.6
Benzoyl-CoA: 43.8
Acetyl-CoA: 34.8
inactive: 25.4
3-Methylbutyryl-CoA: 21.8
fatty_acid: 19.7

PKS_AT (1549..1829): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; inactive: 66.7%; Methylmalonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 179.7
inactive: 86.9
Methylmalonyl-CoA: 78.0
Methoxymalonyl-CoA: 75.3
Isobutyryl-CoA: 46.8
Ethylmalonyl-CoA: 44.6
Acetyl-CoA: 29.5
Propionyl-CoA: 27.4
Benzoyl-CoA: 25.5
2-Methylbutyryl-CoA: 22.2
CHC-CoA: 21.3
trans-1,2-CPDA: 17.9
fatty_acid: 15.0
3-Methylbutyryl-CoA: 4.5

PKS_AT (3063..3357): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 200.2
Ethylmalonyl-CoA: 193.1
Methoxymalonyl-CoA: 154.1
2-Methylbutyryl-CoA: 131.7
Propionyl-CoA: 106.4
trans-1,2-CPDA: 105.2
CHC-CoA: 103.6
Malonyl-CoA: 94.3
Isobutyryl-CoA: 50.0
Benzoyl-CoA: 43.8
3-Methylbutyryl-CoA: 39.1
Acetyl-CoA: 36.5
fatty_acid: 25.8
inactive: 24.0

PKS_AT (4811..5105): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 203.2
Ethylmalonyl-CoA: 188.1
Methoxymalonyl-CoA: 159.3
2-Methylbutyryl-CoA: 130.5
trans-1,2-CPDA: 109.8
Propionyl-CoA: 107.3
CHC-CoA: 104.7
Malonyl-CoA: 98.0
Benzoyl-CoA: 54.2
Acetyl-CoA: 52.1
Isobutyryl-CoA: 51.5
3-Methylbutyryl-CoA: 42.2
inactive: 27.4
fatty_acid: 23.7

AJW65408.1

PKS_AT (537..815): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; inactive: 66.7%; Methylmalonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 177.5
Methylmalonyl-CoA: 83.5
inactive: 80.4
Methoxymalonyl-CoA: 79.9
Isobutyryl-CoA: 50.9
Ethylmalonyl-CoA: 42.4
Propionyl-CoA: 33.9
Benzoyl-CoA: 26.4
trans-1,2-CPDA: 25.2
Acetyl-CoA: 25.2
CHC-CoA: 23.7
2-Methylbutyryl-CoA: 21.5
fatty_acid: 15.6
3-Methylbutyryl-CoA: 2.2

PKS_AT (2038..2318): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; inactive: 66.7%; Methylmalonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 187.0
Methylmalonyl-CoA: 82.5
Methoxymalonyl-CoA: 81.1
inactive: 77.0
Isobutyryl-CoA: 49.5
Ethylmalonyl-CoA: 49.1
Propionyl-CoA: 38.9
Acetyl-CoA: 33.5
Benzoyl-CoA: 29.4
trans-1,2-CPDA: 24.7
2-Methylbutyryl-CoA: 24.5
CHC-CoA: 22.5
fatty_acid: 18.7
3-Methylbutyryl-CoA: 5.7

PKS_AT (3542..3822): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; inactive: 66.7%; Methylmalonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 176.6
inactive: 78.3
Methylmalonyl-CoA: 72.6
Methoxymalonyl-CoA: 72.4
Ethylmalonyl-CoA: 39.8
Isobutyryl-CoA: 37.2
Propionyl-CoA: 33.0
Benzoyl-CoA: 29.9
Acetyl-CoA: 27.2
2-Methylbutyryl-CoA: 22.7
trans-1,2-CPDA: 20.1
CHC-CoA: 18.2
fatty_acid: 12.7
3-Methylbutyryl-CoA: 3.5

AJW65409.1

PKS_AT (569..863): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 207.4
Ethylmalonyl-CoA: 197.5
Methoxymalonyl-CoA: 164.2
2-Methylbutyryl-CoA: 126.2
trans-1,2-CPDA: 112.7
CHC-CoA: 108.0
Propionyl-CoA: 106.8
Malonyl-CoA: 103.9
Isobutyryl-CoA: 56.4
Benzoyl-CoA: 55.0
Acetyl-CoA: 51.9
3-Methylbutyryl-CoA: 43.5
inactive: 27.6
fatty_acid: 24.5

PKS_AT (2313..2605): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 204.6
Ethylmalonyl-CoA: 198.6
Methoxymalonyl-CoA: 166.7
2-Methylbutyryl-CoA: 145.5
trans-1,2-CPDA: 128.8
Propionyl-CoA: 122.0
CHC-CoA: 119.3
Malonyl-CoA: 104.1
Isobutyryl-CoA: 71.7
Acetyl-CoA: 53.1
Benzoyl-CoA: 48.8
fatty_acid: 47.5
3-Methylbutyryl-CoA: 37.6
inactive: 34.5

PKS_AT (3325..3606): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; inactive: 66.7%; Methylmalonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 170.0
inactive: 86.0
Methylmalonyl-CoA: 71.1
Methoxymalonyl-CoA: 65.7
Isobutyryl-CoA: 37.2
Propionyl-CoA: 31.4
Ethylmalonyl-CoA: 27.2
Benzoyl-CoA: 25.3
Acetyl-CoA: 24.5
CHC-CoA: 21.5
2-Methylbutyryl-CoA: 20.2
fatty_acid: 13.1
trans-1,2-CPDA: 11.5
3-Methylbutyryl-CoA: 0.9

AJW65410.1

PKS_AT (563..857): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 87.5%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 191.4
inactive: 90.4
Methoxymalonyl-CoA: 72.7
Methylmalonyl-CoA: 66.7
Isobutyryl-CoA: 38.6
Propionyl-CoA: 38.0
Ethylmalonyl-CoA: 35.7
Benzoyl-CoA: 22.1
fatty_acid: 20.3
Acetyl-CoA: 17.5
trans-1,2-CPDA: 12.4
2-Methylbutyryl-CoA: 11.8
CHC-CoA: 10.6
3-Methylbutyryl-CoA: 0.0