BGC0001567 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001567 (Streptomyces lincolnensis)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	30,866	JBIR-78 / JBIR-95	NRP	88%

BGC0001567 - Region 1 - NRPS

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Location: 1 - 30,866 nt. (total: 30,866 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 30,867
Label		BGC0001567

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001567.1	0.80	NRP	cysteoamide	Streptomyces lincolnensis
BGC0001628.1	0.39	NRP	JBIR-78, JBIR-95	Kibdelosporangium sp. AK-AA56
BGC0000389.1	0.38	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0000426.1	0.38	NRP	sevadicin	Paenibacillus larvae
BGC0001434.1	0.37	NRP	nematophin	Xenorhabdus budapestensis
BGC0001698.1	0.37	NRP	nevaltophin A, nevaltophin B, nevaltophin C, nevaltophin D	Xenorhabdus budapestensis
BGC0001185.1	0.34	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0000465.1	0.33	NRP	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061
BGC0000401.1	0.33	NRP	paenibactin	Paenibacillus elgii B69
BGC0002075.1	0.33	NRP, Alkaloid	Pyreudione A, Pyreudione B, Pyreudione C, Pyreudione D, Pyreudione E	Pseudomonas fluorescens

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001567.1	0.93	NRP	cysteoamide	Streptomyces lincolnensis
BGC0001628.1	0.71	NRP	JBIR-78, JBIR-95	Kibdelosporangium sp. AK-AA56
BGC0000389.1	0.70	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0000426.1	0.70	NRP	sevadicin	Paenibacillus larvae
BGC0001434.1	0.70	NRP	nematophin	Xenorhabdus budapestensis
BGC0001698.1	0.70	NRP	nevaltophin A, nevaltophin B, nevaltophin C, nevaltophin D	Xenorhabdus budapestensis
BGC0001185.1	0.67	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0000465.1	0.67	NRP	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061
BGC0000401.1	0.66	NRP	paenibactin	Paenibacillus elgii B69
BGC0002075.1	0.66	NRP, Alkaloid	Pyreudione A, Pyreudione B, Pyreudione C, Pyreudione D, Pyreudione E	Pseudomonas fluorescens

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 30866:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (val - D-X) + (thr - D-val) + (ala)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

SLINC_0742

Search NORINE for peptide: strict or relaxed

AMP-binding (483..877): ala

NRPSPredictor2: ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: gly, ala
Single AA prediction:: ala

Stachelhaus prediction details:

Stachelhaus sequence:: DVfsaGFIyK
Nearest Stachelhaus code:: lys
Stachelhaus code match:: 60% (weak)

SLINC_0743

Search NORINE for peptide: strict or relaxed

AMP-binding (483..881): thr

NRPSPredictor2: thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: thr
Single AA prediction:: thr

Stachelhaus prediction details:

Stachelhaus sequence:: DFWNVGMVHK
Nearest Stachelhaus code:: thr
Stachelhaus code match:: 100% (strong)

AMP-binding (1542..1907): val

NRPSPredictor2: val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAmLIGAVcK
Nearest Stachelhaus code:: val
Stachelhaus code match:: 80% (moderate)

SLINC_0744

Search NORINE for peptide: strict or relaxed

AMP-binding (453..841): val

NRPSPredictor2: val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: val

Stachelhaus prediction details:

Stachelhaus sequence:: DAYWWGGTFK
Nearest Stachelhaus code:: val
Stachelhaus code match:: 100% (strong)

AMP-binding (1499..1882): X

NRPSPredictor2: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: asp, asn
Single AA prediction:: asn

Stachelhaus prediction details:

Stachelhaus sequence:: DaTKMGHVGK
Nearest Stachelhaus code:: asp
Stachelhaus code match:: 90% (moderate)