BGC0002880 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002880 (Hormoscilla sp. GUM007)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	37,957	Desoxydysinosin B/Desoxydysinosin C	NRPS:Type I	100%

BGC0002880 - Region 1 - NRPS

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Location: 1 - 37,957 nt. (total: 37,957 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 37,958
Label		BGC0002880

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000457	0.31	NRP	vicibactin	Rhizobium etli CFN 42
BGC0002437	0.30	NRP	thermoactinoamide A	Thermoactinomyces sp. AS95
BGC0000426	0.30	NRP	sevadicin	Paenibacillus larvae
BGC0001133	0.30	NRP	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0001748	0.30	NRP, Polyketide	pseudospumigin A, pseudospumigin B, pseudospumigin C, pseudospumigin D, pseudospumigin E, pseudospumigin F	Nostoc sp. CENA543
BGC0001502	0.29	NRP	amonabactin P 750	Aeromonas hydrophila subsp. hydrophila ATCC 7966
BGC0002287	0.29	NRP	mutanocyclin, leuvalin, tyrvalin	Streptococcus mutans
BGC0002058	0.29	Polyketide, NRP	mutanocyclin	Streptococcus mutans B04Sm5
BGC0001671	0.28	NRP	monobactam	Agrobacterium tumefaciens
BGC0000887	0.28	Alkaloid	saxitoxin, gonyautoxin 2, gonyautoxin 3, toxin C2, toxin C3, gonyautoxin 5, decarbamoylsaxitoxin, decarbamoylgonyautoxin 2, decarbamoylgonyautoxin 3	Dolichospermum circinale AWQC131C

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000457	0.64	NRP	vicibactin	Rhizobium etli CFN 42
BGC0002437	0.64	NRP	thermoactinoamide A	Thermoactinomyces sp. AS95
BGC0000426	0.64	NRP	sevadicin	Paenibacillus larvae
BGC0001133	0.63	NRP	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0001748	0.63	NRP, Polyketide	pseudospumigin A, pseudospumigin B, pseudospumigin C, pseudospumigin D, pseudospumigin E, pseudospumigin F	Nostoc sp. CENA543
BGC0001502	0.63	NRP	amonabactin P 750	Aeromonas hydrophila subsp. hydrophila ATCC 7966
BGC0002287	0.62	NRP	mutanocyclin, leuvalin, tyrvalin	Streptococcus mutans
BGC0002058	0.62	Polyketide, NRP	mutanocyclin	Streptococcus mutans B04Sm5
BGC0001671	0.62	NRP	monobactam	Agrobacterium tumefaciens
BGC0000887	0.62	Alkaloid	saxitoxin, gonyautoxin 2, gonyautoxin 3, toxin C2, toxin C3, gonyautoxin 5, decarbamoylsaxitoxin, decarbamoylgonyautoxin 2, decarbamoylgonyautoxin 3	Dolichospermum circinale AWQC131C

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 37957:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-Val) + (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

dysB

Search NORINE for peptide: strict or relaxed

AMP-binding (1814..2207): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DALFIGIILK
Nearest Stachelhaus code(s):: Val DALFVGIVLK (65% 8Å match)
Stachelhaus code match:: 80% (moderate)

dysG

AMP-binding (473..873): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: pro (Pro)
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: DVHIICFLVK
Nearest Stachelhaus code(s):: cohOhi DVHIIAFLVK (91% 8Å match)
Stachelhaus code match:: 90% (moderate)