BGC0000038 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000038 (Streptomyces coelicolor A3(2))

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS,butyrolactone	1	57,887	tirandamycin	NRP + Polyketide:Modular type I	33%

BGC0000038 - Region 1 - T1PKS,butyrolactone

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Location: 1 - 57,887 nt. (total: 57,887 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
butyrolactone: AfsA

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 57,888
Label		BGC0000038

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000849.1	2.00	Other, , (, B, u, t, y, r, o, l, a, c, t, o, n, e, )	SCB1, SCB2, SCB3	Streptomyces coelicolor A3(2)
BGC0000038.1	0.96	Polyketide	coelimycin P1	Streptomyces coelicolor A3(2)
BGC0000848.1	0.86	Other	A-factor	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000850.1	0.72	Other	γ-butyrolactone	Streptomyces acidiscabies
BGC0000131.1	0.55	Polyketide	pyrrolomycin	Streptomyces sp. UC 11065
BGC0000234.1	0.41	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000041.1	0.35	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001458.1	0.34	Other, , (, A, m, i, n, o, c, o, u, m, a, r, i, n, )	salinipostin G	Salinispora tropica CNB-440
BGC0001596.1	0.32	Polyketide	fluostatins M-Q	Streptomyces albus
BGC0000068.1	0.31	Polyketide	geldanamycin	Streptomyces hygroscopicus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000849.1	1.00	Other, , (, B, u, t, y, r, o, l, a, c, t, o, n, e, )	SCB1, SCB2, SCB3	Streptomyces coelicolor A3(2)
BGC0000038.1	0.94	Polyketide	coelimycin P1	Streptomyces coelicolor A3(2)
BGC0000848.1	0.74	Other	A-factor	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000234.1	0.73	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000850.1	0.69	Other	γ-butyrolactone	Streptomyces acidiscabies
BGC0000041.1	0.68	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001596.1	0.65	Polyketide	fluostatins M-Q	Streptomyces albus
BGC0000068.1	0.65	Polyketide	geldanamycin	Streptomyces hygroscopicus
BGC0000236.1	0.64	Polyketide	kinamycin	Streptomyces murayamaensis
BGC0001273.1	0.63	Polyketide	asperlactone	Aspergillus ochraceus

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 57887:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - ccmal - ccmal) + (ccmal - ccmal) + (ccmal)
Non-colinear ordering:: SCO6275 + SCO6274 + SCO6273

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

SCO6273

PKS_AT (565..854): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 171.9
inactive: 73.8
Methoxymalonyl-CoA: 62.1
Methylmalonyl-CoA: 40.8
Propionyl-CoA: 29.3
Acetyl-CoA: 18.6
Isobutyryl-CoA: 15.6
2-Methylbutyryl-CoA: 14.1
Benzoyl-CoA: 9.6
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

SCO6274

PKS_AT (578..871): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 171.9
inactive: 73.8
Methoxymalonyl-CoA: 62.1
Methylmalonyl-CoA: 40.8
Propionyl-CoA: 29.3
Acetyl-CoA: 18.6
Isobutyryl-CoA: 15.6
2-Methylbutyryl-CoA: 14.1
Benzoyl-CoA: 9.6
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2332..2621): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 171.9
inactive: 73.8
Methoxymalonyl-CoA: 62.1
Methylmalonyl-CoA: 40.8
Propionyl-CoA: 29.3
Acetyl-CoA: 18.6
Isobutyryl-CoA: 15.6
2-Methylbutyryl-CoA: 14.1
Benzoyl-CoA: 9.6
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

SCO6275

PKS_AT (548..829): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 209.2
inactive: 103.5
Methoxymalonyl-CoA: 75.4
Methylmalonyl-CoA: 68.4
Isobutyryl-CoA: 37.8
2-Methylbutyryl-CoA: 31.3
Benzoyl-CoA: 30.9
Acetyl-CoA: 30.9
Propionyl-CoA: 29.8
Ethylmalonyl-CoA: 28.1
fatty_acid: 20.5
CHC-CoA: 16.6
3-Methylbutyryl-CoA: 15.4
trans-1,2-CPDA: 15.0

PKS_AT (1549..1846): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 203.5
inactive: 97.1
Methoxymalonyl-CoA: 72.9
Methylmalonyl-CoA: 61.7
Isobutyryl-CoA: 41.7
Propionyl-CoA: 30.9
Ethylmalonyl-CoA: 16.8
Acetyl-CoA: 16.8
2-Methylbutyryl-CoA: 14.2
Benzoyl-CoA: 13.3
3-Methylbutyryl-CoA: 9.0
fatty_acid: 8.4
CHC-CoA: 3.9
trans-1,2-CPDA: 0.0

PKS_AT (3286..3585): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 207.6
inactive: 105.9
Methoxymalonyl-CoA: 62.0
Methylmalonyl-CoA: 50.9
Propionyl-CoA: 30.8
Ethylmalonyl-CoA: 17.7
Isobutyryl-CoA: 16.7
2-Methylbutyryl-CoA: 15.7
Acetyl-CoA: 15.4
Benzoyl-CoA: 11.6
CHC-CoA: 9.5
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0