BGC0000414 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000414 (Streptomyces melanovinaceus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	48,769	naphthyridinomycin	NRP	35%

BGC0000414 - Region 1 - NRPS

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Location: 1 - 48,769 nt. (total: 48,769 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 48,770
Label		BGC0000414

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000414.1	0.98	NRP	quinocarcin	Streptomyces melanovinaceus
BGC0000457.1	0.36	NRP	vicibactin	Rhizobium etli CFN 42
BGC0001399.1	0.33	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0001345.1	0.32	NRP	myxochelin A, myxochelin B	Stigmatella aurantiaca Sg a15
BGC0000389.1	0.30	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0001748.1	0.30	NRP, Polyketide	pseudospumigin A, pseudospumigin B, pseudospumigin C, pseudospumigin D, pseudospumigin E, pseudospumigin F	Nostoc sp. CENA543
BGC0000352.1	0.30	NRP	fimsbactin A	Acinetobacter sp. ADP1
BGC0002058.1	0.29	Other	Reutericyclin A, Reutericyclin B, Reutericyclin C, Reutericyclin D	Streptococcus mutans B04Sm5
BGC0002071.1	0.29	NRP	Virginiafactin	Pseudomonas sp. QS1027
BGC0001132.1	0.28	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000414.1	0.99	NRP	quinocarcin	Streptomyces melanovinaceus
BGC0000457.1	0.69	NRP	vicibactin	Rhizobium etli CFN 42
BGC0001399.1	0.66	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0001345.1	0.66	NRP	myxochelin A, myxochelin B	Stigmatella aurantiaca Sg a15
BGC0000389.1	0.64	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0001748.1	0.63	NRP, Polyketide	pseudospumigin A, pseudospumigin B, pseudospumigin C, pseudospumigin D, pseudospumigin E, pseudospumigin F	Nostoc sp. CENA543
BGC0000352.1	0.63	NRP	fimsbactin A	Acinetobacter sp. ADP1
BGC0002058.1	0.63	Other	Reutericyclin A, Reutericyclin B, Reutericyclin C, Reutericyclin D	Streptococcus mutans B04Sm5
BGC0002071.1	0.62	NRP	Virginiafactin	Pseudomonas sp. QS1027
BGC0001132.1	0.62	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 419 - 48769:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ala) + (X) + (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

qcn12

Search NORINE for peptide: strict or relaxed

AMP-binding (498..886): ala

NRPSPredictor2: ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: gly, ala
Single AA prediction:: ala

Stachelhaus prediction details:

Stachelhaus sequence:: DLFNNALTYK
Nearest Stachelhaus code:: ala
Stachelhaus code match:: 100% (strong)

qcn13

CAL_domain (180..508): pk

minowa: NH2

Prediction, score:

NH2: 127.8
fatty_acid: 47.5
Acetyl-CoA: 30.9
AHBA: 13.4
shikimic_acid: 9.7

qcn15

Search NORINE for peptide: strict or relaxed

AMP-binding (483..895): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DgWvViLasK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 50% (weak)

qcn17

Search NORINE for peptide: strict or relaxed

AMP-binding (491..890): X

NRPSPredictor2: val, leu, ile, abu, iva

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAgdIAeVwK
Nearest Stachelhaus code:: phe
Stachelhaus code match:: 60% (weak)

qcn19

Search NORINE for peptide: strict or relaxed

AMP-binding (377..775): X

NRPSPredictor2: gly, ala, val, leu, ile, abu, iva

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DgsHSGdVwK
Nearest Stachelhaus code:: glu
Stachelhaus code match:: 60% (weak)