BGC0000428 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000428 (Streptosporangium sibiricum)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	32,713	anthramycin	NRP	48%

BGC0000428 - Region 1 - NRPS

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Location: 1 - 32,713 nt. (total: 32,713 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 32,714
Label		BGC0000428

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000428.1	0.93	NRP	sibiromycin	Streptosporangium sibiricum
BGC0001627.1	0.33	NRP	isonitrile lipopeptides	Mycobacterium tuberculosis H37Rv
BGC0001399.1	0.31	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0001527.1	0.31	Other	basidioferrin	Gelatoporia subvermispora
BGC0000426.1	0.30	NRP	sevadicin	Paenibacillus larvae
BGC0000465.1	0.30	NRP	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061
BGC0000389.1	0.30	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0001050.1	0.30	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0002071.1	0.30	NRP	Virginiafactin	Pseudomonas sp. QS1027
BGC0002002.1	0.29	NRP	1,6-phenazinedimethanol, fontizine A	Serratia fonticola

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000428.1	1.00	NRP	sibiromycin	Streptosporangium sibiricum
BGC0001627.1	0.67	NRP	isonitrile lipopeptides	Mycobacterium tuberculosis H37Rv
BGC0001399.1	0.65	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0001527.1	0.65	Other	basidioferrin	Gelatoporia subvermispora
BGC0000426.1	0.64	NRP	sevadicin	Paenibacillus larvae
BGC0000465.1	0.64	NRP	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061
BGC0000389.1	0.63	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0001050.1	0.63	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0002071.1	0.63	NRP	Virginiafactin	Pseudomonas sp. QS1027
BGC0002002.1	0.63	NRP	1,6-phenazinedimethanol, fontizine A	Serratia fonticola

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 27342:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

sibD

Search NORINE for peptide: strict or relaxed

AMP-binding (525..926): X

NRPSPredictor2: trp, tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVMFYTALVK
Nearest Stachelhaus code:: trp, tyr
Stachelhaus code match:: 100% (strong)

sibE

Search NORINE for peptide: strict or relaxed

AMP-binding (15..405): X

NRPSPredictor2: gly, ala, val, leu, ile, abu, iva

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: aAtnIsAalK
Nearest Stachelhaus code:: phe
Stachelhaus code match:: 40% (weak)