BGC0000441 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000441 (Actinoplanes teichomyceticus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS,T3PKS	1	89,976	teicoplanin	NRP:Glycopeptide	84%

BGC0000441 - Region 1 - NRPS,T3PKS

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Location: 1 - 89,976 nt. (total: 89,976 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 89,977
Label		BGC0000441

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000441.1	0.91	NRP	teicoplanin	Actinoplanes teichomyceticus
BGC0000440.1	0.82	NRP	teicoplanin	Actinoplanes teichomyceticus
BGC0000902.1	0.55	Other	flaviolin	Saccharopolyspora erythraea NRRL 2338
BGC0000285.1	0.55	Polyketide, Saccharide	flaviolin rhamnoside, 3,3'-diflaviolin, flaviolin	Saccharopolyspora erythraea
BGC0001310.1	0.55	Terpene	naringenin	Streptomyces clavuligerus ATCC 27064
BGC0001335.1	0.53	Alkaloid	borregomycin A, borregomycin B, borregomycin C, borregomycin D	uncultured bacterium
BGC0000653.1	0.51	Terpene	pentalenolactone	Streptomyces arenae
BGC0001075.1	0.51	Terpene, Polyketide	aurachin RE	Rhodococcus erythropolis
BGC0001444.1	0.47	Other	caboxamycin	Streptomyces sp. NTK 937
BGC0000679.1	0.46	Terpene	diazepinomicin	Micromonospora sp. M42

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000441.1	0.89	NRP	teicoplanin	Actinoplanes teichomyceticus
BGC0000440.1	0.82	NRP	teicoplanin	Actinoplanes teichomyceticus
BGC0000389.1	0.70	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0002071.1	0.68	NRP	Virginiafactin	Pseudomonas sp. QS1027
BGC0000876.1	0.68	Other	neopolyoxin C	Streptomyces tendae
BGC0000427.1	0.68	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0000375.1	0.67	NRP	indigoidine	Streptomyces chromofuscus
BGC0000902.1	0.67	Other	flaviolin	Saccharopolyspora erythraea NRRL 2338
BGC0000285.1	0.67	Polyketide, Saccharide	flaviolin rhamnoside, 3,3'-diflaviolin, flaviolin	Saccharopolyspora erythraea
BGC0001310.1	0.67	Terpene	naringenin	Streptomyces clavuligerus ATCC 27064

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 87559:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (hpg - D-tyr) + (dhpg) + (D-hpg - D-hpg - bht) + (dhpg)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 0 - 61276:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (hpg - D-tyr) + (dhpg) + (D-hpg - D-hpg - bht) + (dhpg)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

teiA

Search NORINE for peptide: strict or relaxed

AMP-binding (15..402): hpg

NRPSPredictor2: hpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: dhpg, hpg
Single AA prediction:: hpg

Stachelhaus prediction details:

Stachelhaus sequence:: DAFHLGLLCK
Nearest Stachelhaus code:: hpg
Stachelhaus code match:: 100% (strong)

AMP-binding (1037..1423): tyr

NRPSPredictor2: tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: tyr, bht
Single AA prediction:: tyr

Stachelhaus prediction details:

Stachelhaus sequence:: DASTVAAVCK
Nearest Stachelhaus code:: tyr
Stachelhaus code match:: 100% (strong)

teiB

Search NORINE for peptide: strict or relaxed

AMP-binding (466..854): dhpg

NRPSPredictor2: dhpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: dhpg, hpg
Single AA prediction:: dhpg

Stachelhaus prediction details:

Stachelhaus sequence:: DAYNLGTLCK
Nearest Stachelhaus code:: dhpg
Stachelhaus code match:: 100% (strong)

teiC

Search NORINE for peptide: strict or relaxed

AMP-binding (459..852): hpg

NRPSPredictor2: hpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: dhpg, hpg
Single AA prediction:: hpg

Stachelhaus prediction details:

Stachelhaus sequence:: DIFHLGLLCK
Nearest Stachelhaus code:: hpg
Stachelhaus code match:: 100% (strong)

AMP-binding (1956..2348): hpg

NRPSPredictor2: hpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: dhpg, hpg
Single AA prediction:: hpg

Stachelhaus prediction details:

Stachelhaus sequence:: DALHLGLLCK
Nearest Stachelhaus code:: hpg
Stachelhaus code match:: 100% (strong)

AMP-binding (3467..3853): bht

NRPSPredictor2: bht

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: tyr, bht
Single AA prediction:: bht

Stachelhaus prediction details:

Stachelhaus sequence:: DASTIAGVCK
Nearest Stachelhaus code:: bht
Stachelhaus code match:: 100% (strong)

teiD

Search NORINE for peptide: strict or relaxed

AMP-binding (470..870): dhpg

NRPSPredictor2: dhpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: dhpg, hpg
Single AA prediction:: dhpg

Stachelhaus prediction details:

Stachelhaus sequence:: DPYHGGTLCK
Nearest Stachelhaus code:: dhpg
Stachelhaus code match:: 100% (strong)

CAG15025.1

CAL_domain (40..467): pk

minowa: NH2

Prediction, score:

NH2: 94.7
fatty_acid: 48.3
AHBA: 3.8
Acetyl-CoA: 3.4
shikimic_acid: 0.0