BGC0000950 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000950 (Streptomyces sp. DSM 5940)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS-like	1	35,298	pacidamycin 1 / pacidamycin 2 / pacidamycin 3 / pacidamycin 4 / pacidamycin 5 / pacidamycin 6 / pacidamycin 7 / pacidamycin D	NRP	100%

BGC0000950 - Region 1 - NRPS-like

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Location: 1 - 35,298 nt. (total: 35,298 nt) Show pHMM detection rules used

Region on contig edge.

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 35,299
Label		BGC0000950

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000950.1	1.72	NRP, Other, , (, N, u, c, l, e, o, s, i, d, e, )	napsamycin A, napsamycin B, napsamycin C, napsamycin D, mureidomycin A, mureidomycin B	Streptomyces sp. DSM 5940
BGC0000375.1	0.69	NRP	indigoidine	Streptomyces chromofuscus
BGC0000427.1	0.68	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0000900.1	0.64	Other	ferrichrome	Aspergillus oryzae
BGC0000348.1	0.63	NRP	ergovaline	Epichloe festucae var. lolii
BGC0001249.1	0.63	NRP	dimethylcoprogen	Alternaria alternata
BGC0000876.1	0.57	Other	neopolyoxin C	Streptomyces tendae
BGC0001479.1	0.57	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0000921.1	0.56	Other, Polyketide, NRP, , (, S, h, i, k, i, m, a, t, e, -, d, e, r, i, v, e, d, )	promysalin	Pseudomonas putida
BGC0001561.1	0.54	NRP	curacomycin	Streptomyces curacoi

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000950.1	0.95	NRP, Other, , (, N, u, c, l, e, o, s, i, d, e, )	napsamycin A, napsamycin B, napsamycin C, napsamycin D, mureidomycin A, mureidomycin B	Streptomyces sp. DSM 5940
BGC0000375.1	0.67	NRP	indigoidine	Streptomyces chromofuscus
BGC0000427.1	0.67	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0000900.1	0.66	Other	ferrichrome	Aspergillus oryzae
BGC0000348.1	0.65	NRP	ergovaline	Epichloe festucae var. lolii
BGC0001249.1	0.65	NRP	dimethylcoprogen	Alternaria alternata
BGC0000921.1	0.62	Other, Polyketide, NRP, , (, S, h, i, k, i, m, a, t, e, -, d, e, r, i, v, e, d, )	promysalin	Pseudomonas putida
BGC0000876.1	0.62	Other	neopolyoxin C	Streptomyces tendae
BGC0001479.1	0.62	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0001718.1	0.61	NRP	okaramine D	Aspergillus aculeatus ATCC 16872

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 33350:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 0 - 27607:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

npsP3

Search NORINE for peptide: strict or relaxed

AMP-binding (283..679): X

NRPSPredictor2: hydrophobic-aliphatic

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DpgiyGLLaK
Nearest Stachelhaus code:: phg
Stachelhaus code match:: 50% (weak)

npsP5

Search NORINE for peptide: strict or relaxed

AMP-binding (30..426): X

NRPSPredictor2: (unknown)

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DiWQgtadDK
Nearest Stachelhaus code:: gln
Stachelhaus code match:: 50% (weak)

npsP6

Search NORINE for peptide: strict or relaxed

AMP-binding (16..412): X

NRPSPredictor2: hydrophobic-aliphatic

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DPhHfGliGK
Nearest Stachelhaus code:: glu
Stachelhaus code match:: 60% (weak)

npsP8

Search NORINE for peptide: strict or relaxed

AMP-binding (19..420): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DgLilGicVK
Nearest Stachelhaus code:: leu
Stachelhaus code match:: 50% (weak)