BGC0000955 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000955 (Myxococcus xanthus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS,NRPS	1	33,020	althiomycin	NRP	50%

BGC0000955 - Region 1 - NRPS,T1PKS

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Location: 1 - 33,020 nt. (total: 33,020 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 33,021
Label		BGC0000955

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000955.1	2.00	NRP, Polyketide	althiomycin	Myxococcus xanthus
BGC0001415.1	0.77	NRP	althiomycin	Serratia marcescens subsp. marcescens Db11
BGC0000426.1	0.73	NRP	sevadicin	Paenibacillus larvae
BGC0001479.1	0.64	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0000375.1	0.63	NRP	indigoidine	Streptomyces chromofuscus
BGC0000404.1	0.57	NRP	penicillin	Penicillium chrysogenum
BGC0002058.1	0.57	Other	Reutericyclin A, Reutericyclin B, Reutericyclin C, Reutericyclin D	Streptococcus mutans B04Sm5
BGC0001878.1	0.56	NRP, Polyketide	detoxin N2, detoxin N3	Streptomyces sp. NRRL B-1347
BGC0000351.1	0.55	NRP	exochelin	Mycolicibacterium smegmatis
BGC0001132.1	0.54	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000955.1	1.00	NRP, Polyketide	althiomycin	Myxococcus xanthus
BGC0001415.1	0.71	NRP	althiomycin	Serratia marcescens subsp. marcescens Db11
BGC0000426.1	0.69	NRP	sevadicin	Paenibacillus larvae
BGC0001479.1	0.66	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0000375.1	0.65	NRP	indigoidine	Streptomyces chromofuscus
BGC0000404.1	0.62	NRP	penicillin	Penicillium chrysogenum
BGC0002058.1	0.62	Other	Reutericyclin A, Reutericyclin B, Reutericyclin C, Reutericyclin D	Streptococcus mutans B04Sm5
BGC0001878.1	0.62	NRP, Polyketide	detoxin N2, detoxin N3	Streptomyces sp. NRRL B-1347
BGC0000351.1	0.61	NRP	exochelin	Mycolicibacterium smegmatis
BGC0001132.1	0.60	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 33020:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (gly - cys) + (D-ser - D-cys - gly - mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

almA

Search NORINE for peptide: strict or relaxed

AMP-binding (383..786): gly

NRPSPredictor2: gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: gly, ala
Single AA prediction:: gly

Stachelhaus prediction details:

Stachelhaus sequence:: DILQLGVvWK
Nearest Stachelhaus code:: gly
Stachelhaus code match:: 90% (moderate)

AMP-binding (1457..1857): cys

NRPSPredictor2: cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: cys
Small clusters prediction:: cys
Single AA prediction:: cys

Stachelhaus prediction details:

Stachelhaus sequence:: DLYNLSLIWK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 100% (strong)

almB

Search NORINE for peptide: strict or relaxed

AMP-binding (532..946): ser

NRPSPredictor2: ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: ser
Single AA prediction:: ser

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHFSLIDK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 100% (strong)

AMP-binding (2074..2479): cys

NRPSPredictor2: cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: cys
Small clusters prediction:: cys
Single AA prediction:: cys

Stachelhaus prediction details:

Stachelhaus sequence:: DLYNMSMIWK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 100% (strong)

AMP-binding (3583..3983): gly

NRPSPredictor2: gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: gly, ala
Single AA prediction:: gly

Stachelhaus prediction details:

Stachelhaus sequence:: DILQLGVIWK
Nearest Stachelhaus code:: gly
Stachelhaus code match:: 100% (strong)

PKS_AT (4708..5000): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 83.3%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 148.2
inactive: 85.4
Methoxymalonyl-CoA: 66.5
Methylmalonyl-CoA: 47.4
Propionyl-CoA: 36.4
Ethylmalonyl-CoA: 19.4
Isobutyryl-CoA: 18.8
2-Methylbutyryl-CoA: 12.8
CHC-CoA: 11.9
Benzoyl-CoA: 11.4
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0