BGC0001011 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001011 (Streptomyces sp. NRRL 30748)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS,T1PKS	1	116,831	meridamycin	NRP + Polyketide	26%

BGC0001011 - Region 1 - NRPS,T1PKS

Download region GenBank file

Download region SVG

Location: 1 - 116,831 nt. (total: 116,831 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 116,832
Label		BGC0001011

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001011.1	1.11	NRP, Polyketide	meridamycin	Streptomyces sp. NRRL 30748
BGC0001050.1	0.67	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0000457.1	0.63	NRP	vicibactin	Rhizobium etli CFN 42
BGC0001012.1	0.63	NRP, Polyketide	meridamycin	Streptomyces violaceusniger
BGC0000417.1	0.56	NRP	rhodochelin	Rhodococcus jostii RHA1
BGC0001399.1	0.56	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0000342.1	0.55	NRP	enniatin	Fusarium equiseti
BGC0000313.1	0.55	NRP	beauvericin	Beauveria bassiana
BGC0002057.1	0.54	Polyketide	pateamine	Kiritimatiellaeota bacterium
BGC0001185.1	0.53	NRP	bacillibactin	Bacillus velezensis FZB42

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001011.1	0.92	NRP, Polyketide	meridamycin	Streptomyces sp. NRRL 30748
BGC0001012.1	0.74	NRP, Polyketide	meridamycin	Streptomyces violaceusniger
BGC0000041.1	0.67	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001050.1	0.67	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0000457.1	0.66	NRP	vicibactin	Rhizobium etli CFN 42
BGC0001854.1	0.65	Polyketide	tricholignan A	Trichoderma harzianum
BGC0001901.1	0.65	Polyketide	tricholignan A	Trichoderma harzianum
BGC0001399.1	0.64	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0000067.1	0.64	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001283.1	0.64	Polyketide	arsono-polyketide	Streptomyces lividans 1326

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 1567 - 116831:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pip) + (mal - pk - Me-ccmal - ohmal) + (pk - pk - pk - pk) + (ohmal - ohmal - pk - ohmal - ohmal) + (pk - ccmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

merP

Search NORINE for peptide: strict or relaxed

AMP-binding (502..918): pip

NRPSPredictor2: pip

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: pro, pip
Small clusters prediction:: pro
Single AA prediction:: pro

Stachelhaus prediction details:

Stachelhaus sequence:: DIQFSAHVVK
Nearest Stachelhaus code:: pip
Stachelhaus code match:: 100% (strong)

merA

PKS_AT (582..880): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 190.8
inactive: 94.4
Methoxymalonyl-CoA: 69.9
Methylmalonyl-CoA: 51.4
Propionyl-CoA: 26.6
Isobutyryl-CoA: 25.4
Ethylmalonyl-CoA: 21.5
Acetyl-CoA: 20.3
fatty_acid: 16.1
2-Methylbutyryl-CoA: 13.8
Benzoyl-CoA: 10.0
CHC-CoA: 9.4
trans-1,2-CPDA: 5.1
3-Methylbutyryl-CoA: 0.0

PKS_AT (1591..1876): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 220.0
Methylmalonyl-CoA: 213.8
Methoxymalonyl-CoA: 171.9
2-Methylbutyryl-CoA: 144.0
trans-1,2-CPDA: 139.9
CHC-CoA: 128.0
Propionyl-CoA: 113.7
Malonyl-CoA: 91.7
Isobutyryl-CoA: 79.3
Benzoyl-CoA: 73.8
Acetyl-CoA: 51.7
fatty_acid: 40.7
inactive: 23.2
3-Methylbutyryl-CoA: 19.9

PKS_AT (3044..3329): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 209.8
Ethylmalonyl-CoA: 209.1
Methoxymalonyl-CoA: 166.8
2-Methylbutyryl-CoA: 145.0
trans-1,2-CPDA: 143.6
Propionyl-CoA: 121.2
CHC-CoA: 118.7
Malonyl-CoA: 87.8
Isobutyryl-CoA: 73.0
Benzoyl-CoA: 67.4
Acetyl-CoA: 53.4
fatty_acid: 41.2
inactive: 22.6
3-Methylbutyryl-CoA: 10.9

PKS_AT (4719..4992): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 212.4
inactive: 116.1
Methoxymalonyl-CoA: 61.2
Methylmalonyl-CoA: 49.5
Isobutyryl-CoA: 37.6
Propionyl-CoA: 33.5
Ethylmalonyl-CoA: 28.5
Benzoyl-CoA: 28.3
Acetyl-CoA: 18.1
2-Methylbutyryl-CoA: 15.5
fatty_acid: 14.7
CHC-CoA: 11.7
trans-1,2-CPDA: 10.9
3-Methylbutyryl-CoA: 0.0

merB

PKS_AT (558..856): pk

ATSignature: Methoxymalonyl-CoA

Top 3 matches:: Methoxymalonyl-CoA: 87.5%; Ethylmalonyl-CoA: 83.3%; Methylmalonyl-CoA: 79.2%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 186.1
Methylmalonyl-CoA: 179.0
Methoxymalonyl-CoA: 152.5
2-Methylbutyryl-CoA: 119.3
trans-1,2-CPDA: 115.7
Propionyl-CoA: 95.4
CHC-CoA: 89.3
Malonyl-CoA: 81.7
Isobutyryl-CoA: 59.3
fatty_acid: 40.2
Benzoyl-CoA: 33.8
Acetyl-CoA: 29.6
inactive: 20.4
3-Methylbutyryl-CoA: 16.0

PKS_AT (2268..2554): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 214.2
Methylmalonyl-CoA: 208.4
Methoxymalonyl-CoA: 168.0
2-Methylbutyryl-CoA: 148.0
trans-1,2-CPDA: 140.9
CHC-CoA: 114.4
Propionyl-CoA: 113.2
Malonyl-CoA: 88.2
Isobutyryl-CoA: 63.8
Benzoyl-CoA: 55.2
Acetyl-CoA: 40.4
fatty_acid: 40.2
3-Methylbutyryl-CoA: 31.1
inactive: 21.9

PKS_AT (3808..4093): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 211.5
Methylmalonyl-CoA: 210.3
Methoxymalonyl-CoA: 167.2
2-Methylbutyryl-CoA: 148.1
trans-1,2-CPDA: 144.0
CHC-CoA: 121.1
Propionyl-CoA: 120.3
Malonyl-CoA: 89.1
Isobutyryl-CoA: 76.7
Benzoyl-CoA: 70.2
Acetyl-CoA: 56.1
fatty_acid: 41.1
inactive: 25.4
3-Methylbutyryl-CoA: 10.9

PKS_AT (5843..6128): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 214.1
Methylmalonyl-CoA: 209.3
Methoxymalonyl-CoA: 167.0
trans-1,2-CPDA: 142.1
2-Methylbutyryl-CoA: 136.4
CHC-CoA: 124.0
Propionyl-CoA: 117.0
Malonyl-CoA: 89.0
Isobutyryl-CoA: 72.4
Benzoyl-CoA: 62.3
Acetyl-CoA: 46.7
fatty_acid: 33.3
inactive: 21.2
3-Methylbutyryl-CoA: 11.6

merC

PKS_AT (571..844): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 211.4
inactive: 114.8
Methoxymalonyl-CoA: 58.0
Methylmalonyl-CoA: 49.7
Isobutyryl-CoA: 36.1
Propionyl-CoA: 32.8
Ethylmalonyl-CoA: 30.7
Benzoyl-CoA: 25.9
Acetyl-CoA: 19.4
fatty_acid: 18.9
2-Methylbutyryl-CoA: 14.0
trans-1,2-CPDA: 10.2
CHC-CoA: 8.9
3-Methylbutyryl-CoA: 0.0

PKS_AT (2024..2297): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 210.7
inactive: 113.5
Methoxymalonyl-CoA: 63.3
Methylmalonyl-CoA: 52.5
Isobutyryl-CoA: 38.9
Propionyl-CoA: 35.5
Ethylmalonyl-CoA: 29.4
Benzoyl-CoA: 26.4
Acetyl-CoA: 19.5
2-Methylbutyryl-CoA: 16.2
fatty_acid: 14.7
trans-1,2-CPDA: 12.5
CHC-CoA: 12.4
3-Methylbutyryl-CoA: 0.0

PKS_AT (3477..3764): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 220.4
Methylmalonyl-CoA: 215.2
Methoxymalonyl-CoA: 171.6
2-Methylbutyryl-CoA: 146.9
trans-1,2-CPDA: 145.4
CHC-CoA: 124.6
Propionyl-CoA: 117.3
Malonyl-CoA: 89.4
Isobutyryl-CoA: 72.8
Benzoyl-CoA: 63.4
Acetyl-CoA: 48.4
fatty_acid: 40.7
inactive: 17.5
3-Methylbutyryl-CoA: 15.6

PKS_AT (5004..5277): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 210.5
inactive: 112.2
Methoxymalonyl-CoA: 60.5
Methylmalonyl-CoA: 52.8
Propionyl-CoA: 36.1
Isobutyryl-CoA: 35.1
Ethylmalonyl-CoA: 32.6
Acetyl-CoA: 23.4
Benzoyl-CoA: 20.5
2-Methylbutyryl-CoA: 18.5
fatty_acid: 15.2
trans-1,2-CPDA: 12.1
CHC-CoA: 11.9
3-Methylbutyryl-CoA: 0.0

PKS_AT (6458..6731): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 209.9
inactive: 109.3
Methoxymalonyl-CoA: 62.3
Methylmalonyl-CoA: 47.6
Propionyl-CoA: 30.7
Isobutyryl-CoA: 26.2
Benzoyl-CoA: 26.0
Ethylmalonyl-CoA: 25.1
Acetyl-CoA: 20.1
2-Methylbutyryl-CoA: 14.0
fatty_acid: 11.6
CHC-CoA: 10.6
trans-1,2-CPDA: 9.9
3-Methylbutyryl-CoA: 0.0

merD

PKS_AT (158..431): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 217.7
Methylmalonyl-CoA: 210.8
Methoxymalonyl-CoA: 167.1
2-Methylbutyryl-CoA: 151.3
trans-1,2-CPDA: 138.3
CHC-CoA: 118.9
Propionyl-CoA: 114.3
Malonyl-CoA: 85.2
Isobutyryl-CoA: 70.2
Benzoyl-CoA: 64.0
Acetyl-CoA: 51.7
fatty_acid: 37.7
inactive: 20.2
3-Methylbutyryl-CoA: 15.6

PKS_AT (2288..2577): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 83.3%; inactive: 70.8%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 192.5
inactive: 94.1
Methoxymalonyl-CoA: 66.1
Methylmalonyl-CoA: 60.2
Propionyl-CoA: 38.4
Ethylmalonyl-CoA: 29.8
Isobutyryl-CoA: 27.4
Acetyl-CoA: 22.7
CHC-CoA: 16.4
fatty_acid: 13.8
2-Methylbutyryl-CoA: 12.6
trans-1,2-CPDA: 10.8
Benzoyl-CoA: 10.5
3-Methylbutyryl-CoA: 0.0