BGC0001021 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001021 (Mycobacterium tuberculosis H37Rv)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	23,821	gobichelin A / gobichelin B	NRP	16%

BGC0001021 - Region 1 - NRPS

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Location: 1 - 23,821 nt. (total: 23,821 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 23,822
Label		BGC0001021

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001021.1	0.96	NRP, Polyketide	mycobactin	Mycobacterium tuberculosis H37Rv
BGC0000389.1	0.33	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0002071.1	0.33	NRP	Virginiafactin	Pseudomonas sp. QS1027
BGC0001023.1	0.30	NRP, Polyketide	myxochromide S1	Stigmatella aurantiaca
BGC0000457.1	0.29	NRP	vicibactin	Rhizobium etli CFN 42
BGC0001629.1	0.29	NRP	Jessenipeptin	Pseudomonas sp. QS1027
BGC0001050.1	0.28	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0001876.1	0.28	NRP	thalassospiramide A	Thalassospira sp. CNJ-328
BGC0000901.1	0.27	Other	ferrichrome	Aspergillus niger
BGC0001027.1	0.26	NRP, Polyketide	nocobactin NA	Nocardia farcinica IFM 10152

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001021.1	0.99	NRP, Polyketide	mycobactin	Mycobacterium tuberculosis H37Rv
BGC0000389.1	0.66	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0002071.1	0.66	NRP	Virginiafactin	Pseudomonas sp. QS1027
BGC0001023.1	0.63	NRP, Polyketide	myxochromide S1	Stigmatella aurantiaca
BGC0000457.1	0.63	NRP	vicibactin	Rhizobium etli CFN 42
BGC0001629.1	0.63	NRP	Jessenipeptin	Pseudomonas sp. QS1027
BGC0001050.1	0.62	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0001876.1	0.61	NRP	thalassospiramide A	Thalassospira sp. CNJ-328
BGC0000901.1	0.61	Other	ferrichrome	Aspergillus niger
BGC0001027.1	0.60	NRP, Polyketide	nocobactin NA	Nocardia farcinica IFM 10152

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 23821:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-lys) + (lys) + (Me-ohmal) + (ser-thr)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

Rv2379c

Search NORINE for peptide: strict or relaxed

AMP-binding (476..862): lys

NRPSPredictor2: lys

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: orn, lys, arg
Small clusters prediction:: N/A
Single AA prediction:: lys

Stachelhaus prediction details:

Stachelhaus sequence:: DAwDAGCVEK
Nearest Stachelhaus code:: lys
Stachelhaus code match:: 90% (moderate)

Rv2380c

Search NORINE for peptide: strict or relaxed

AMP-binding (446..828): lys

NRPSPredictor2: lys

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: orn, lys, arg
Small clusters prediction:: N/A
Single AA prediction:: lys

Stachelhaus prediction details:

Stachelhaus sequence:: DVAHPGFINK
Nearest Stachelhaus code:: lys
Stachelhaus code match:: 100% (strong)

Rv2381c

PKS_AT (99..401): mmal

ATSignature: Malonyl-CoA, Methylmalonyl-CoA

Top 3 matches:: Malonyl-CoA: 54.2%; Methylmalonyl-CoA: 54.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 102.5
Methoxymalonyl-CoA: 87.7
Ethylmalonyl-CoA: 76.7
2-Methylbutyryl-CoA: 50.0
trans-1,2-CPDA: 48.7
Propionyl-CoA: 44.9
Isobutyryl-CoA: 40.9
CHC-CoA: 40.3
Benzoyl-CoA: 37.0
Acetyl-CoA: 24.5
3-Methylbutyryl-CoA: 19.5
fatty_acid: 16.5
inactive: 14.5
Malonyl-CoA: 3.1

Rv2383c

Search NORINE for peptide: strict or relaxed

AMP-binding (557..951): ser-thr

NRPSPredictor2: ser-thr

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DMLNAGLVHK
Nearest Stachelhaus code:: ser-thr
Stachelhaus code match:: 100% (strong)

Rv2384

Search NORINE for peptide: strict or relaxed

AMP-binding (47..456): sal

NRPSPredictor2: sal

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: dhb, sal
Small clusters prediction:: dhb, sal
Single AA prediction:: dhb

Stachelhaus prediction details:

Stachelhaus sequence:: PLPAQGVLNK
Nearest Stachelhaus code:: sal
Stachelhaus code match:: 100% (strong)