BGC0001027 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001027 (Nocardia farcinica IFM 10152)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	20,510	mycobactin	NRP + Polyketide	30%

BGC0001027 - Region 1 - NRPS

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Location: 1 - 20,510 nt. (total: 20,510 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 20,511
Label		BGC0001027

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001027.1	1.00	NRP, Polyketide	nocobactin NA	Nocardia farcinica IFM 10152
BGC0000426.1	0.38	NRP	sevadicin	Paenibacillus larvae
BGC0001050.1	0.35	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0000389.1	0.35	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0001629.1	0.34	NRP	Jessenipeptin	Pseudomonas sp. QS1027
BGC0002071.1	0.33	NRP	Virginiafactin	Pseudomonas sp. QS1027
BGC0000465.1	0.32	NRP	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061
BGC0001434.1	0.32	NRP	nematophin	Xenorhabdus budapestensis
BGC0001698.1	0.32	NRP	nevaltophin A, nevaltophin B, nevaltophin C, nevaltophin D	Xenorhabdus budapestensis
BGC0001023.1	0.31	NRP, Polyketide	myxochromide S1	Stigmatella aurantiaca

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001027.1	1.00	NRP, Polyketide	nocobactin NA	Nocardia farcinica IFM 10152
BGC0000426.1	0.70	NRP	sevadicin	Paenibacillus larvae
BGC0001050.1	0.68	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0000389.1	0.68	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0001629.1	0.67	NRP	Jessenipeptin	Pseudomonas sp. QS1027
BGC0002071.1	0.66	NRP	Virginiafactin	Pseudomonas sp. QS1027
BGC0000465.1	0.66	NRP	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061
BGC0001434.1	0.65	NRP	nematophin	Xenorhabdus budapestensis
BGC0001698.1	0.65	NRP	nevaltophin A, nevaltophin B, nevaltophin C, nevaltophin D	Xenorhabdus budapestensis
BGC0001023.1	0.65	NRP, Polyketide	myxochromide S1	Stigmatella aurantiaca

Similar known gene clusters

Module view

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 20510:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-ohmal) + (leu) + (D-lys) + (cys)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

NFA_7650

PKS_AT (100..391): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 62.5%; Malonyl-CoA: 58.3%; Ethylmalonyl-CoA: 54.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 94.5
Methoxymalonyl-CoA: 89.1
Malonyl-CoA: 75.6
Ethylmalonyl-CoA: 73.0
Propionyl-CoA: 54.7
trans-1,2-CPDA: 51.6
2-Methylbutyryl-CoA: 46.9
Isobutyryl-CoA: 46.4
inactive: 23.9
CHC-CoA: 23.0
fatty_acid: 21.9
Benzoyl-CoA: 21.5
3-Methylbutyryl-CoA: 21.1
Acetyl-CoA: 21.0

NFA_7660

Search NORINE for peptide: strict or relaxed

AMP-binding (497..886): leu

NRPSPredictor2: leu

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: leu

Stachelhaus prediction details:

Stachelhaus sequence:: DALHpGhvCK
Nearest Stachelhaus code:: hpg
Stachelhaus code match:: 70% (weak)

NFA_7670

Search NORINE for peptide: strict or relaxed

AMP-binding (468..867): lys

NRPSPredictor2: lys

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: orn, lys, arg
Small clusters prediction:: N/A
Single AA prediction:: lys

Stachelhaus prediction details:

Stachelhaus sequence:: DAwDAGCVEK
Nearest Stachelhaus code:: lys
Stachelhaus code match:: 90% (moderate)

NFA_7680

Search NORINE for peptide: strict or relaxed

AMP-binding (567..963): cys

NRPSPredictor2: cys

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: cys
Small clusters prediction:: cys
Single AA prediction:: cys

Stachelhaus prediction details:

Stachelhaus sequence:: DAyntGLIhK
Nearest Stachelhaus code:: gln
Stachelhaus code match:: 60% (weak)