BGC0001425 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001425 (Myxococcus xanthus DK 1622)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS,T1PKS	1	44,135	myxochromide A	NRP:Cyclic depsipeptide + Polyketide:Iterative type I	100%

BGC0001425 - Region 1 - NRPS,T1PKS

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Location: 1 - 44,135 nt. (total: 44,135 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 44,136
Label		BGC0001425

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001425.1	0.87	NRP, Polyketide	myxochromide A	Myxococcus xanthus DK 1622
BGC0001426.1	0.76	NRP, Polyketide	myxochromide A	Myxococcus xanthus
BGC0001023.1	0.76	NRP, Polyketide	myxochromide S1	Stigmatella aurantiaca
BGC0001427.1	0.74	NRP, Polyketide	myxochromide A	Myxococcus xanthus
BGC0001428.1	0.65	NRP, Polyketide	myxochromide A	Myxococcus xanthus
BGC0001423.1	0.61	NRP, Polyketide	myxochromide C	Myxococcus hansupus
BGC0001424.1	0.61	NRP, Polyketide	myxochromide C	Myxococcus virescens
BGC0001421.1	0.61	NRP, Polyketide	myxochromide B	Myxococcus sp.
BGC0001422.1	0.60	NRP, Polyketide	myxochromide A	Myxococcus fulvus HW-1
BGC0000389.1	0.55	NRP	massetolide A	Pseudomonas fluorescens SS101

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001425.1	0.81	NRP, Polyketide	myxochromide A	Myxococcus xanthus DK 1622
BGC0001023.1	0.80	NRP, Polyketide	myxochromide S1	Stigmatella aurantiaca
BGC0001426.1	0.77	NRP, Polyketide	myxochromide A	Myxococcus xanthus
BGC0001427.1	0.76	NRP, Polyketide	myxochromide A	Myxococcus xanthus
BGC0001428.1	0.72	NRP, Polyketide	myxochromide A	Myxococcus xanthus
BGC0000389.1	0.71	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0002071.1	0.70	NRP	Virginiafactin	Pseudomonas sp. QS1027
BGC0001423.1	0.70	NRP, Polyketide	myxochromide C	Myxococcus hansupus
BGC0001424.1	0.70	NRP, Polyketide	myxochromide C	Myxococcus virescens
BGC0001421.1	0.69	NRP, Polyketide	myxochromide B	Myxococcus sp.

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 44135:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk) + (NMe-thr - D-pro) + (leu - pro - phe - gln)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

mchA

PKS_AT (544..840): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; CE-Malonyl-CoA: 62.5%; Methylmalonyl-CoA: 54.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 112.8
Malonyl-CoA: 103.8
Isobutyryl-CoA: 98.1
Methoxymalonyl-CoA: 93.4
Ethylmalonyl-CoA: 81.0
2-Methylbutyryl-CoA: 51.5
Propionyl-CoA: 51.3
Benzoyl-CoA: 46.0
trans-1,2-CPDA: 40.5
CHC-CoA: 40.1
Acetyl-CoA: 31.2
3-Methylbutyryl-CoA: 24.3
inactive: 22.9
fatty_acid: 19.9

mchB

Search NORINE for peptide: strict or relaxed

AMP-binding (508..912): thr

NRPSPredictor2: thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: thr
Single AA prediction:: thr

Stachelhaus prediction details:

Stachelhaus sequence:: DFWNIGMVHK
Nearest Stachelhaus code:: thr
Stachelhaus code match:: 100% (strong)

AMP-binding (2007..2397): pro

NRPSPredictor2: pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: phe, trp
Single AA prediction:: pro

Stachelhaus prediction details:

Stachelhaus sequence:: DvWvIAAViK
Nearest Stachelhaus code:: phe
Stachelhaus code match:: 70% (weak)

mchC

Search NORINE for peptide: strict or relaxed

AMP-binding (470..856): leu

NRPSPredictor2: leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: leu

Stachelhaus prediction details:

Stachelhaus sequence:: DAWFLGNVVK
Nearest Stachelhaus code:: leu
Stachelhaus code match:: 100% (strong)

AMP-binding (1505..1900): pro

NRPSPredictor2: pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: pro, pip
Small clusters prediction:: pro
Single AA prediction:: pro

Stachelhaus prediction details:

Stachelhaus sequence:: DVQFIAHVVK
Nearest Stachelhaus code:: pro
Stachelhaus code match:: 100% (strong)

AMP-binding (2554..2944): phe

NRPSPredictor2: phe

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: phe, trp
Single AA prediction:: phe

Stachelhaus prediction details:

Stachelhaus sequence:: DVWvtAAIiK
Nearest Stachelhaus code:: ala
Stachelhaus code match:: 70% (weak)

AMP-binding (3597..3988): gln

NRPSPredictor2: gln

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAWQcGLIDK
Nearest Stachelhaus code:: gln
Stachelhaus code match:: 90% (moderate)