BGC0001816 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001816 (Shuttle vector AtFAC9J20)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS-like,T1PKS,NRPS	1	118,762

BGC0001816 - Region 1 - NRPS,NRPS-like,T1PKS

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Location: 1 - 118,762 nt. (total: 118,762 nt) Show pHMM detection rules used

Region on contig edge.

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 118,763
Label		BGC0001816

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001816.1	1.36	NRP, Polyketide	valactamide A	Shuttle vector AtFAC9J20
BGC0001261.1	0.60	NRP	AM-toxin	Alternaria alternata
BGC0000900.1	0.54	Other	ferrichrome	Aspergillus oryzae
BGC0001249.1	0.54	NRP	dimethylcoprogen	Alternaria alternata
BGC0001132.1	0.53	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001166.1	0.51	NRP	HC-toxin	Alternaria jesenskae
BGC0000342.1	0.51	NRP	enniatin	Fusarium equiseti
BGC0000396.1	0.51	NRP	nodularin	Nostoc sp. 73.1
BGC0001135.1	0.51	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001833.1	0.51	NRP	icosalide A, icosalide B	Burkholderia gladioli

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001816.1	0.98	NRP, Polyketide	valactamide A	Shuttle vector AtFAC9J20
BGC0001249.1	0.66	NRP	dimethylcoprogen	Alternaria alternata
BGC0000900.1	0.66	Other	ferrichrome	Aspergillus oryzae
BGC0000348.1	0.66	NRP	ergovaline	Epichloe festucae var. lolii
BGC0001858.1	0.66	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0001261.1	0.66	NRP	AM-toxin	Alternaria alternata
BGC0000427.1	0.65	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0000442.1	0.65	NRP	terrequinone A	Aspergillus nidulans FGSC A4
BGC0001068.1	0.64	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0001517.1	0.64	NRP	asperphenamate	Aspergillus terreus NIH2624

Similar known gene clusters

No matches found.

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 1113 - 22733:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 30179 - 109688:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-pk) + (X - X) + (X - X) + (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 30179 - 77992:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - X) + (X - X) + (Me-pk)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 4, location 38953 - 109688:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-pk) + (X - X) + (X - X) + (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

AQM58276.1

Search NORINE for peptide: strict or relaxed

AMP-binding (10..434): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: glu, gln
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: vAiFaGGagK
Nearest Stachelhaus code:: tyr
Stachelhaus code match:: 50% (weak)

lptB

PKS_AT (557..881): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; Methylmalonyl-CoA: 62.5%; Ethylmalonyl-CoA: 58.3%

minowa: Methoxymalonyl-CoA

Prediction, score:

Methoxymalonyl-CoA: 72.7
Methylmalonyl-CoA: 72.5
Malonyl-CoA: 52.1
Isobutyryl-CoA: 43.5
Ethylmalonyl-CoA: 39.9
Propionyl-CoA: 34.0
Benzoyl-CoA: 31.4
fatty_acid: 26.5
trans-1,2-CPDA: 24.6
2-Methylbutyryl-CoA: 22.0
CHC-CoA: 14.8
3-Methylbutyryl-CoA: 10.1
Acetyl-CoA: 9.8
inactive: 0.0

lptA

Search NORINE for peptide: strict or relaxed

AMP-binding (410..804): X

NRPSPredictor2: gly, ala, val, leu, ile, abu, iva

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DALlLGiTiK
Nearest Stachelhaus code:: val
Stachelhaus code match:: 70% (weak)

AMP-binding (1524..1933): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DlGfsGpIiK
Nearest Stachelhaus code:: orn
Stachelhaus code match:: 50% (weak)

benZ

Search NORINE for peptide: strict or relaxed

AMP-binding (263..662): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: GInfiGAGtK
Nearest Stachelhaus code:: tcl
Stachelhaus code match:: 60% (weak)

AMP-binding (1342..1734): X

NRPSPredictor2: hydrophilic

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DmnVMGgVtK
Nearest Stachelhaus code:: phe
Stachelhaus code match:: 60% (weak)

benY

Search NORINE for peptide: strict or relaxed

AMP-binding (45..443): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: gmFiVGLgMK
Nearest Stachelhaus code:: d-lyserg
Stachelhaus code match:: 60% (weak)