BGC0000162 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000162 (Micromonospora chalcea)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	other,T1PKS	1	108,236	lobophorin A	Polyketide	48%

BGC0000162 - Region 1 - T1PKS,other

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Location: 1 - 108,236 nt. (total: 108,236 nt) Show pHMM detection rules used

Region on contig edge.

other: (LmbU or Neocarzinostat or fom1 or bcpB or frbD or mitE or vlmB or prnB or CaiA or bacilysin or orf2_PTase)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 108,237
Label		BGC0000162

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000162.1	1.12	Polyketide	tetrocarcin A	Micromonospora chalcea
BGC0001302.1	0.44	Other	lomofungin	Streptomyces lomondensis
BGC0001386.1	0.43	Polyketide	JBIR-76, JBIR-77	Streptomyces sp. RI-77
BGC0001476.1	0.43	Other, , (, N, u, c, l, e, o, s, i, d, e, )	pseudouridimycin	Streptomyces sp.
BGC0000692.1	0.39	Saccharide	apramycin	Streptoalloteichus hindustanus
BGC0000237.1	0.39	Polyketide	lactonamycin Z	Streptomyces sanglieri
BGC0000204.1	0.38	Polyketide	benastatin A, benastatin B, BE-43767, TAN1532B	Streptomyces sp. A2991200
BGC0000880.1	0.38	Other, , (, N, u, c, l, e, o, s, i, d, e, )	tunicamycin B1	Streptomyces chartreusis NRRL 3882
BGC0000277.1	0.37	Polyketide	urdamycin	Streptomyces fradiae
BGC0000273.1	0.37	Polyketide, Saccharide	steffimycin D	Streptomyces steffisburgensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000162.1	0.94	Polyketide	tetrocarcin A	Micromonospora chalcea
BGC0000068.1	0.69	Polyketide	geldanamycin	Streptomyces hygroscopicus
BGC0000018.1	0.64	Polyketide	angolamycin	Streptomyces eurythermus
BGC0001273.1	0.64	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001704.1	0.64	Other	nocuolin A	Nodularia sp. HBU26
BGC0000122.1	0.64	Polyketide	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla
BGC0001276.1	0.64	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001854.1	0.64	Polyketide	tricholignan A	Trichoderma harzianum
BGC0001901.1	0.64	Polyketide	tricholignan A	Trichoderma harzianum
BGC0001164.1	0.64	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 1289 - 108236:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk - pk - pk - Me-ccmal) + (ccmal - Me-ccmal - ccmal - ccmal) + (Me-ccmal) + (pk - Me-ccmal) + (ohmal)
Non-colinear ordering:: ACB37740.1 + ACB37741.1 + ACB37742.1 + ACB37755.1 + ACB37743.1

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 5662 - 108236:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk - pk - pk - Me-ccmal) + (ccmal - Me-ccmal - ccmal - ccmal) + (Me-ccmal) + (pk - Me-ccmal) + (ohmal)
Non-colinear ordering:: ACB37740.1 + ACB37741.1 + ACB37742.1 + ACB37755.1 + ACB37743.1

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ACB37740.1

PKS_AT (540..834): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; Methylmalonyl-CoA: 83.3%; Methoxymalonyl-CoA: 75.0%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 177.1
Ethylmalonyl-CoA: 166.9
Methoxymalonyl-CoA: 137.3
trans-1,2-CPDA: 95.8
Malonyl-CoA: 93.2
CHC-CoA: 87.9
2-Methylbutyryl-CoA: 82.6
Propionyl-CoA: 75.6
Isobutyryl-CoA: 54.9
Benzoyl-CoA: 47.0
Acetyl-CoA: 32.7
fatty_acid: 31.7
inactive: 27.8
3-Methylbutyryl-CoA: 21.9

PKS_AT (1551..1849): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 193.4
Ethylmalonyl-CoA: 187.7
Methoxymalonyl-CoA: 159.8
2-Methylbutyryl-CoA: 125.4
trans-1,2-CPDA: 108.2
Propionyl-CoA: 103.4
Malonyl-CoA: 83.8
CHC-CoA: 79.6
Isobutyryl-CoA: 68.7
Benzoyl-CoA: 66.7
Acetyl-CoA: 40.9
3-Methylbutyryl-CoA: 32.6
inactive: 29.7
fatty_acid: 29.6

PKS_AT (3309..3600): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; Methylmalonyl-CoA: 83.3%; Methoxymalonyl-CoA: 75.0%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 177.1
Ethylmalonyl-CoA: 166.9
Methoxymalonyl-CoA: 137.3
trans-1,2-CPDA: 95.8
Malonyl-CoA: 93.2
CHC-CoA: 87.9
2-Methylbutyryl-CoA: 82.6
Propionyl-CoA: 75.6
Isobutyryl-CoA: 54.9
Benzoyl-CoA: 47.0
Acetyl-CoA: 32.7
fatty_acid: 31.7
inactive: 27.8
3-Methylbutyryl-CoA: 21.9

PKS_AT (5048..5342): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 83.3%; Methoxymalonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 180.0
Ethylmalonyl-CoA: 175.3
Methoxymalonyl-CoA: 150.4
trans-1,2-CPDA: 119.4
2-Methylbutyryl-CoA: 105.5
Malonyl-CoA: 101.7
CHC-CoA: 95.8
Propionyl-CoA: 86.7
Isobutyryl-CoA: 47.9
Benzoyl-CoA: 46.5
inactive: 38.5
Acetyl-CoA: 25.5
fatty_acid: 20.4
3-Methylbutyryl-CoA: 7.7

ACB37741.1

PKS_AT (564..851): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 212.2
inactive: 101.1
Methoxymalonyl-CoA: 67.9
Methylmalonyl-CoA: 64.3
Propionyl-CoA: 36.7
Ethylmalonyl-CoA: 32.2
Isobutyryl-CoA: 29.7
Acetyl-CoA: 19.8
2-Methylbutyryl-CoA: 19.7
Benzoyl-CoA: 13.7
fatty_acid: 13.5
3-Methylbutyryl-CoA: 10.1
CHC-CoA: 9.5
trans-1,2-CPDA: 7.8

PKS_AT (2265..2556): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 83.3%; Methoxymalonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 178.0
Ethylmalonyl-CoA: 172.6
Methoxymalonyl-CoA: 150.3
trans-1,2-CPDA: 119.5
2-Methylbutyryl-CoA: 102.5
Malonyl-CoA: 101.0
CHC-CoA: 95.9
Propionyl-CoA: 87.1
Isobutyryl-CoA: 48.1
Benzoyl-CoA: 42.7
inactive: 37.5
Acetyl-CoA: 25.5
fatty_acid: 20.4
3-Methylbutyryl-CoA: 8.1

PKS_AT (4012..4293): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 66.7%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 202.9
inactive: 83.9
Methoxymalonyl-CoA: 66.5
Methylmalonyl-CoA: 55.0
Isobutyryl-CoA: 32.9
Propionyl-CoA: 23.4
Ethylmalonyl-CoA: 20.3
fatty_acid: 20.2
Acetyl-CoA: 15.3
Benzoyl-CoA: 14.8
2-Methylbutyryl-CoA: 9.5
trans-1,2-CPDA: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (5754..6050): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 177.3
inactive: 87.0
Methoxymalonyl-CoA: 65.1
Methylmalonyl-CoA: 54.8
Isobutyryl-CoA: 44.2
Ethylmalonyl-CoA: 23.4
Benzoyl-CoA: 20.7
Propionyl-CoA: 19.3
Acetyl-CoA: 15.0
2-Methylbutyryl-CoA: 13.2
fatty_acid: 12.8
CHC-CoA: 9.8
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

ACB37742.1

PKS_AT (562..856): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 83.3%; Methoxymalonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 177.1
Ethylmalonyl-CoA: 166.5
Methoxymalonyl-CoA: 145.4
trans-1,2-CPDA: 113.9
Malonyl-CoA: 99.4
2-Methylbutyryl-CoA: 99.1
CHC-CoA: 98.3
Propionyl-CoA: 85.1
Isobutyryl-CoA: 46.8
Benzoyl-CoA: 37.1
inactive: 35.5
Acetyl-CoA: 24.1
fatty_acid: 19.1
3-Methylbutyryl-CoA: 6.5

ACB37743.1

PKS_AT (571..867): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 194.5
inactive: 92.7
Methoxymalonyl-CoA: 60.0
Methylmalonyl-CoA: 51.1
Propionyl-CoA: 40.1
Ethylmalonyl-CoA: 19.8
2-Methylbutyryl-CoA: 16.9
Acetyl-CoA: 14.8
Isobutyryl-CoA: 10.8
fatty_acid: 7.9
trans-1,2-CPDA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

ACB37755.1

PKS_AT (582..880): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 215.7
Methylmalonyl-CoA: 208.4
Methoxymalonyl-CoA: 172.0
trans-1,2-CPDA: 141.0
2-Methylbutyryl-CoA: 137.9
Propionyl-CoA: 135.7
Malonyl-CoA: 109.3
CHC-CoA: 104.4
Isobutyryl-CoA: 75.8
Benzoyl-CoA: 60.7
fatty_acid: 53.9
Acetyl-CoA: 45.3
3-Methylbutyryl-CoA: 34.4
inactive: 31.7

PKS_AT (2675..2971): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 218.6
Ethylmalonyl-CoA: 209.0
Methoxymalonyl-CoA: 185.0
2-Methylbutyryl-CoA: 155.2
trans-1,2-CPDA: 141.6
Propionyl-CoA: 138.4
CHC-CoA: 120.8
Malonyl-CoA: 113.7
Isobutyryl-CoA: 108.3
Benzoyl-CoA: 71.4
Acetyl-CoA: 64.3
3-Methylbutyryl-CoA: 59.8
fatty_acid: 46.2
inactive: 32.5