BGC0001012 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001012 (Streptomyces violaceusniger)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS,NRPS	1	91,893	meridamycin	NRP + Polyketide	13%

BGC0001012 - Region 1 - NRPS,T1PKS

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Location: 1 - 91,893 nt. (total: 91,893 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 91,894
Label		BGC0001012

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001012.1	1.13	NRP, Polyketide	meridamycin	Streptomyces violaceusniger
BGC0001235.1	0.60	NRP, Polyketide	antalid	Polyangium spumosum
BGC0001013.1	0.57	NRP, Polyketide	meridamycin	Streptomyces sp.
BGC0000342.1	0.54	NRP	enniatin	Fusarium equiseti
BGC0000067.1	0.53	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001132.1	0.49	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001844.1	0.48	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0002057.1	0.48	Polyketide	pateamine	Kiritimatiellaeota bacterium
BGC0001135.1	0.48	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0000313.1	0.48	NRP	beauvericin	Beauveria bassiana

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001012.1	0.92	NRP, Polyketide	meridamycin	Streptomyces violaceusniger
BGC0001013.1	0.68	NRP, Polyketide	meridamycin	Streptomyces sp.
BGC0000067.1	0.64	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000041.1	0.64	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001164.1	0.62	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001011.1	0.61	NRP, Polyketide	meridamycin	Streptomyces sp. NRRL 30748
BGC0000342.1	0.61	NRP	enniatin	Fusarium equiseti
BGC0000313.1	0.61	NRP	beauvericin	Beauveria bassiana
BGC0001665.1	0.59	Polyketide	methylated alkyl-resorcinol, methylated acyl-phloroglucinol	Mycobacterium marinum M
BGC0001132.1	0.58	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 91893:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pip) + (mal - pk - pk - ohmal) + (pk - pk - pk - Me-ccmal) + (ohmal - ohmal - pk - ohmal - ohmal - pk - ccmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

merP

Search NORINE for peptide: strict or relaxed

AMP-binding (502..943): pip

NRPSPredictor2: pip

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: pro, pip
Small clusters prediction:: pro
Single AA prediction:: pro

Stachelhaus prediction details:

Stachelhaus sequence:: DIQFSAHVVK
Nearest Stachelhaus code:: pip
Stachelhaus code match:: 100% (strong)

merA

PKS_AT (578..876): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 188.1
inactive: 92.3
Methoxymalonyl-CoA: 66.7
Methylmalonyl-CoA: 50.5
Acetyl-CoA: 27.5
Propionyl-CoA: 22.9
Isobutyryl-CoA: 22.9
Ethylmalonyl-CoA: 19.3
fatty_acid: 15.7
Benzoyl-CoA: 12.6
2-Methylbutyryl-CoA: 9.5
CHC-CoA: 8.8
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (1595..1883): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 221.3
Methylmalonyl-CoA: 214.3
Methoxymalonyl-CoA: 175.0
2-Methylbutyryl-CoA: 143.4
trans-1,2-CPDA: 136.3
CHC-CoA: 125.7
Propionyl-CoA: 110.1
Malonyl-CoA: 97.5
Isobutyryl-CoA: 81.0
Benzoyl-CoA: 75.3
fatty_acid: 49.8
Acetyl-CoA: 41.3
inactive: 24.9
3-Methylbutyryl-CoA: 19.9

PKS_AT (3048..3333): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 223.7
Methylmalonyl-CoA: 219.4
Methoxymalonyl-CoA: 180.2
2-Methylbutyryl-CoA: 145.4
trans-1,2-CPDA: 145.3
CHC-CoA: 127.2
Propionyl-CoA: 120.7
Malonyl-CoA: 100.9
Isobutyryl-CoA: 82.7
Benzoyl-CoA: 71.8
fatty_acid: 48.3
Acetyl-CoA: 47.3
3-Methylbutyryl-CoA: 30.1
inactive: 25.5

PKS_AT (4722..4994): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 195.9
inactive: 104.2
Methoxymalonyl-CoA: 48.8
Methylmalonyl-CoA: 41.4
Propionyl-CoA: 30.8
Benzoyl-CoA: 24.2
Ethylmalonyl-CoA: 22.0
Isobutyryl-CoA: 21.2
Acetyl-CoA: 19.7
2-Methylbutyryl-CoA: 13.5
fatty_acid: 11.0
CHC-CoA: 10.5
trans-1,2-CPDA: 9.6
3-Methylbutyryl-CoA: 0.0

merB

PKS_AT (557..855): pk

ATSignature: Methoxymalonyl-CoA

Top 3 matches:: Methoxymalonyl-CoA: 87.5%; Ethylmalonyl-CoA: 83.3%; Methylmalonyl-CoA: 79.2%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 185.2
Methylmalonyl-CoA: 178.0
Methoxymalonyl-CoA: 151.4
2-Methylbutyryl-CoA: 113.5
trans-1,2-CPDA: 112.7
Propionyl-CoA: 94.6
CHC-CoA: 87.3
Malonyl-CoA: 74.3
Isobutyryl-CoA: 60.2
fatty_acid: 36.7
Benzoyl-CoA: 35.3
Acetyl-CoA: 33.6
inactive: 20.5
3-Methylbutyryl-CoA: 9.5

PKS_AT (2293..2579): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 221.4
Methylmalonyl-CoA: 211.9
Methoxymalonyl-CoA: 173.9
2-Methylbutyryl-CoA: 154.2
trans-1,2-CPDA: 139.0
Propionyl-CoA: 116.9
CHC-CoA: 113.5
Malonyl-CoA: 88.9
Isobutyryl-CoA: 66.2
Benzoyl-CoA: 59.3
fatty_acid: 39.8
Acetyl-CoA: 37.7
3-Methylbutyryl-CoA: 31.8
inactive: 22.9

PKS_AT (3852..4140): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 212.1
Methylmalonyl-CoA: 208.7
Methoxymalonyl-CoA: 170.0
2-Methylbutyryl-CoA: 144.2
trans-1,2-CPDA: 131.7
CHC-CoA: 123.7
Propionyl-CoA: 121.1
Malonyl-CoA: 95.1
Isobutyryl-CoA: 82.5
Benzoyl-CoA: 72.6
Acetyl-CoA: 47.2
fatty_acid: 43.8
inactive: 31.0
3-Methylbutyryl-CoA: 24.9

PKS_AT (5919..6204): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 202.1
Ethylmalonyl-CoA: 201.3
Methoxymalonyl-CoA: 163.1
2-Methylbutyryl-CoA: 133.9
trans-1,2-CPDA: 133.2
CHC-CoA: 119.0
Propionyl-CoA: 104.9
Malonyl-CoA: 86.0
Isobutyryl-CoA: 71.6
Benzoyl-CoA: 67.9
fatty_acid: 40.7
Acetyl-CoA: 38.6
inactive: 19.9
3-Methylbutyryl-CoA: 8.4

merC

PKS_AT (571..844): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 87.5%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 210.8
inactive: 115.6
Methoxymalonyl-CoA: 53.3
Methylmalonyl-CoA: 46.5
Propionyl-CoA: 37.7
Isobutyryl-CoA: 30.7
Benzoyl-CoA: 24.4
Ethylmalonyl-CoA: 23.8
Acetyl-CoA: 19.0
2-Methylbutyryl-CoA: 18.0
CHC-CoA: 14.4
fatty_acid: 14.1
trans-1,2-CPDA: 12.5
3-Methylbutyryl-CoA: 0.0

PKS_AT (2022..2295): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 87.5%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 205.0
inactive: 121.9
Methoxymalonyl-CoA: 54.6
Methylmalonyl-CoA: 48.2
Isobutyryl-CoA: 36.2
Propionyl-CoA: 35.3
Benzoyl-CoA: 25.3
Ethylmalonyl-CoA: 24.0
Acetyl-CoA: 19.1
fatty_acid: 16.9
2-Methylbutyryl-CoA: 14.3
CHC-CoA: 11.7
trans-1,2-CPDA: 9.1
3-Methylbutyryl-CoA: 0.0

PKS_AT (3472..3760): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 213.0
Methylmalonyl-CoA: 210.2
Methoxymalonyl-CoA: 169.0
2-Methylbutyryl-CoA: 143.5
trans-1,2-CPDA: 139.2
CHC-CoA: 129.5
Propionyl-CoA: 117.9
Malonyl-CoA: 94.2
Isobutyryl-CoA: 81.2
Benzoyl-CoA: 71.4
Acetyl-CoA: 53.7
fatty_acid: 37.0
3-Methylbutyryl-CoA: 26.5
inactive: 26.0

PKS_AT (5006..5279): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 87.5%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 203.7
inactive: 117.2
Methoxymalonyl-CoA: 56.3
Methylmalonyl-CoA: 47.8
Isobutyryl-CoA: 36.6
Propionyl-CoA: 34.9
Ethylmalonyl-CoA: 25.8
Benzoyl-CoA: 21.3
fatty_acid: 15.3
Acetyl-CoA: 15.2
CHC-CoA: 13.2
2-Methylbutyryl-CoA: 11.0
trans-1,2-CPDA: 8.6
3-Methylbutyryl-CoA: 0.0

PKS_AT (6465..6721): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 87.5%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 187.8
inactive: 108.5
Methoxymalonyl-CoA: 45.4
Methylmalonyl-CoA: 38.2
Acetyl-CoA: 20.8
Isobutyryl-CoA: 20.3
Propionyl-CoA: 19.2
Benzoyl-CoA: 14.8
Ethylmalonyl-CoA: 13.1
fatty_acid: 8.9
trans-1,2-CPDA: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (7994..8275): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 220.2
Methylmalonyl-CoA: 208.5
Methoxymalonyl-CoA: 166.9
2-Methylbutyryl-CoA: 148.4
trans-1,2-CPDA: 128.9
CHC-CoA: 117.8
Propionyl-CoA: 108.5
Malonyl-CoA: 84.6
Isobutyryl-CoA: 69.2
Benzoyl-CoA: 58.5
Acetyl-CoA: 46.3
fatty_acid: 35.7
3-Methylbutyryl-CoA: 17.2
inactive: 14.2

PKS_AT (10089..10384): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 186.7
inactive: 91.6
Methoxymalonyl-CoA: 62.6
Methylmalonyl-CoA: 54.9
Propionyl-CoA: 31.7
Isobutyryl-CoA: 29.4
Ethylmalonyl-CoA: 26.7
Acetyl-CoA: 21.2
2-Methylbutyryl-CoA: 14.2
fatty_acid: 13.1
Benzoyl-CoA: 12.9
CHC-CoA: 11.3
trans-1,2-CPDA: 9.8
3-Methylbutyryl-CoA: 0.0