BGC0001569 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001569 (Streptomyces noursei ATCC 11455)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS,betalactone	1	46,257	ulleungmycin	NRPS:Type I	63%

BGC0001569 - Region 1 - NRPS,betalactone

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Location: 1 - 46,257 nt. (total: 46,257 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))
betalactone: (HMGL-like and AMP-binding)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 46,258
Label		BGC0001569

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001569	1.49	NRP	dechlorocuracomycin	Streptomyces noursei ATCC 11455
BGC0001814	0.91	NRP	ulleungmycin	Streptomyces sp. KCB13F003
BGC0001562	0.89	NRP	curacomycin	Streptomyces curacoi
BGC0002437	0.64	NRP	thermoactinoamide A	Thermoactinomyces sp. AS95
BGC0001561	0.63	NRP	curacomycin	Streptomyces curacoi
BGC0000457	0.62	NRP	vicibactin	Rhizobium etli CFN 42
BGC0002017	0.59	NRP	potensibactin	Nocardiopsis potens DSM 45234
BGC0001133	0.59	NRP	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0000426	0.57	NRP	sevadicin	Paenibacillus larvae
BGC0001671	0.57	NRP	monobactam	Agrobacterium tumefaciens

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001569	1.00	NRP	dechlorocuracomycin	Streptomyces noursei ATCC 11455
BGC0001814	0.83	NRP	ulleungmycin	Streptomyces sp. KCB13F003
BGC0001562	0.80	NRP	curacomycin	Streptomyces curacoi
BGC0001561	0.77	NRP	curacomycin	Streptomyces curacoi
BGC0001133	0.71	NRP	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0000426	0.70	NRP	sevadicin	Paenibacillus larvae
BGC0002017	0.68	NRP	potensibactin	Nocardiopsis potens DSM 45234
BGC0002071	0.68	NRP	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0002437	0.67	NRP	thermoactinoamide A	Thermoactinomyces sp. AS95
BGC0000457	0.66	NRP	vicibactin	Rhizobium etli CFN 42

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 46257:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - D-Val - D-X - Val) + (Orn - D-X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

SNOUR_12640

Search NORINE for peptide: strict or relaxed

AMP-binding (518..929): Orn

nrpys: Orn

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DTEDMGFVDK
Nearest Stachelhaus code(s):: Orn DTEDMGFVDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1599..2005): X

nrpys: OH-Asn, Asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asn (Asn)

Stachelhaus prediction details:

Stachelhaus sequence:: DLTKVGEVGK
Nearest Stachelhaus code(s):: OH-Asn or Asn DLTKVGEVGK (100% 8Å match); Trp DLTKVGEVGK (94% 8Å match); Asn DLTKVGEVGK (71% 8Å match)
Stachelhaus code match:: 100% (strong)

SNOUR_12645

Search NORINE for peptide: strict or relaxed

AMP-binding (23..429): X

nrpys: 5-clTrp

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVAMAGAVTK
Nearest Stachelhaus code(s):: 5-clTrp DVAMAGAVTK (100% 8Å match); 6-clTrp DVAMAGAVTK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1107..1506): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: DAFWLGGTFK
Nearest Stachelhaus code(s):: Val DAFWLGGTFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2620..3013): X

nrpys: Leu, Phe

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAIMLGGIAK
Nearest Stachelhaus code(s):: Leu or Phe DAIMLGGIAK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (4137..4542): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: DALWMGGVFK
Nearest Stachelhaus code(s):: Val DALWMGGVFK (100% 8Å match); Ile or Val DALWMGGVFK (62% 8Å match)
Stachelhaus code match:: 100% (strong)