BGC0000421 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000421 (Pseudomonas fluorescens)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	17,974	saframycin A / saframycin B	NRP	6%

BGC0000421 - Region 1 - NRPS

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Location: 1 - 17,974 nt. (total: 17,974 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 17,975
Label		BGC0000421

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000421.1	1.00	NRP	safracin A, safracin B	Pseudomonas fluorescens
BGC0001050.1	0.36	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0000389.1	0.35	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0002071.1	0.34	NRP	Virginiafactin	Pseudomonas sp. QS1027
BGC0000465.1	0.32	NRP	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061
BGC0000426.1	0.32	NRP	sevadicin	Paenibacillus larvae
BGC0001629.1	0.30	NRP	Jessenipeptin	Pseudomonas sp. QS1027
BGC0000438.1	0.28	NRP	syringopeptin 25A	Pseudomonas syringae pv. syringae
BGC0001261.1	0.27	NRP	AM-toxin	Alternaria alternata
BGC0001876.1	0.27	NRP	thalassospiramide A	Thalassospira sp. CNJ-328

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000421.1	1.00	NRP	safracin A, safracin B	Pseudomonas fluorescens
BGC0001050.1	0.69	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0000389.1	0.68	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0002071.1	0.67	NRP	Virginiafactin	Pseudomonas sp. QS1027
BGC0000465.1	0.66	NRP	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061
BGC0000426.1	0.65	NRP	sevadicin	Paenibacillus larvae
BGC0001629.1	0.63	NRP	Jessenipeptin	Pseudomonas sp. QS1027
BGC0000438.1	0.61	NRP	syringopeptin 25A	Pseudomonas syringae pv. syringae
BGC0001261.1	0.61	NRP	AM-toxin	Alternaria alternata
BGC0001876.1	0.61	NRP	thalassospiramide A	Thalassospira sp. CNJ-328

Similar known gene clusters

Module view

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 17974:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ala) + (gly) + (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

sfcA

Search NORINE for peptide: strict or relaxed

AMP-binding (419..803): ala

NRPSPredictor2: ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: gly, ala
Single AA prediction:: ala

Stachelhaus prediction details:

Stachelhaus sequence:: DLFNNALTYK
Nearest Stachelhaus code:: ala
Stachelhaus code match:: 100% (strong)

sfcB

Search NORINE for peptide: strict or relaxed

AMP-binding (464..848): gly

NRPSPredictor2: gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: N/A
Single AA prediction:: gly

Stachelhaus prediction details:

Stachelhaus sequence:: DILQLGLIWK
Nearest Stachelhaus code:: gly
Stachelhaus code match:: 100% (strong)

sfcC

Search NORINE for peptide: strict or relaxed

AMP-binding (454..841): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DpWglGLIDK
Nearest Stachelhaus code:: gln
Stachelhaus code match:: 70% (weak)