BGC0001010 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001010 (Melittangium lichenicola)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS,T1PKS	1	51,855	melithiazol A	NRP + Polyketide	100%

BGC0001010 - Region 1 - NRPS,T1PKS

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Location: 1 - 51,855 nt. (total: 51,855 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 51,856
Label		BGC0001010

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001010.1	1.61	NRP, Polyketide	melithiazol A	Melittangium lichenicola
BGC0001009.1	1.61	NRP, Polyketide	melithiazol A	Melittangium lichenicola
BGC0001024.1	0.82	NRP, Polyketide	myxothiazol	Stigmatella aurantiaca DW4/3-1
BGC0001050.1	0.64	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0001399.1	0.62	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0000982.1	0.59	NRP, Polyketide	cystothiazole A	Cystobacter fuscus
BGC0001023.1	0.58	NRP, Polyketide	myxochromide S1	Stigmatella aurantiaca
BGC0000046.1	0.55	Polyketide	depudecin	Alternaria brassicicola
BGC0000416.1	0.54	NRP	rhabdopeptide 1, rhabdopeptide 2, rhabdopeptide 3, rhabdopeptide 4	Xenorhabdus nematophila ATCC 19061
BGC0000373.1	0.53	NRP	holomycin	Streptomyces clavuligerus ATCC 27064

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001010.1	0.93	NRP, Polyketide	melithiazol A	Melittangium lichenicola
BGC0001009.1	0.93	NRP, Polyketide	melithiazol A	Melittangium lichenicola
BGC0001024.1	0.73	NRP, Polyketide	myxothiazol	Stigmatella aurantiaca DW4/3-1
BGC0001050.1	0.65	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0001399.1	0.64	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0000982.1	0.63	NRP, Polyketide	cystothiazole A	Cystobacter fuscus
BGC0001023.1	0.62	NRP, Polyketide	myxochromide S1	Stigmatella aurantiaca
BGC0000046.1	0.61	Polyketide	depudecin	Alternaria brassicicola
BGC0000416.1	0.61	NRP	rhabdopeptide 1, rhabdopeptide 2, rhabdopeptide 3, rhabdopeptide 4	Xenorhabdus nematophila ATCC 19061
BGC0000373.1	0.60	NRP	holomycin	Streptomyces clavuligerus ATCC 27064

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 51855:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk) + (cys) + (cys - ccmal) + (OMe-Me-ohmal) + (OMe-mal) + (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

melB

PKS_AT (553..847): pk

ATSignature: Isobutyryl-CoA

Top 3 matches:: Isobutyryl-CoA: 100.0%; Methylmalonyl-CoA: 70.8%; Malonyl-CoA: 58.3%

minowa: Isobutyryl-CoA

Prediction, score:

Isobutyryl-CoA: 236.4
Methylmalonyl-CoA: 90.5
Methoxymalonyl-CoA: 83.7
Malonyl-CoA: 73.6
Propionyl-CoA: 33.6
Benzoyl-CoA: 30.8
fatty_acid: 27.0
3-Methylbutyryl-CoA: 25.3
inactive: 25.2
Acetyl-CoA: 19.1
2-Methylbutyryl-CoA: 19.0
CHC-CoA: 11.8
trans-1,2-CPDA: 0.0
Ethylmalonyl-CoA: -1.6

melC

Search NORINE for peptide: strict or relaxed

AMP-binding (517..915): cys

NRPSPredictor2: cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: cys
Small clusters prediction:: cys
Single AA prediction:: cys

Stachelhaus prediction details:

Stachelhaus sequence:: DLYNMSLVWK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 100% (strong)

melD

Search NORINE for peptide: strict or relaxed

AMP-binding (539..938): cys

NRPSPredictor2: cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: cys
Small clusters prediction:: cys
Single AA prediction:: cys

Stachelhaus prediction details:

Stachelhaus sequence:: DLYNLSLIWK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 100% (strong)

PKS_AT (1979..2271): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 62.5%; Isobutyryl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 146.6
inactive: 109.9
Methoxymalonyl-CoA: 77.3
Methylmalonyl-CoA: 61.4
Propionyl-CoA: 41.2
2-Methylbutyryl-CoA: 30.8
Ethylmalonyl-CoA: 29.8
Isobutyryl-CoA: 25.0
CHC-CoA: 23.7
Benzoyl-CoA: 17.9
trans-1,2-CPDA: 15.2
Acetyl-CoA: 11.6
fatty_acid: 10.0
3-Methylbutyryl-CoA: 0.0

melE

PKS_AT (571..866): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 83.3%; Ethylmalonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 175.2
Ethylmalonyl-CoA: 147.8
Methoxymalonyl-CoA: 133.8
Isobutyryl-CoA: 130.7
Benzoyl-CoA: 123.3
Malonyl-CoA: 99.2
Acetyl-CoA: 95.1
2-Methylbutyryl-CoA: 81.3
Propionyl-CoA: 71.6
trans-1,2-CPDA: 67.5
CHC-CoA: 62.1
3-Methylbutyryl-CoA: 44.0
fatty_acid: 43.0
inactive: 31.0

melF

PKS_AT (569..861): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 62.5%; Isobutyryl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 146.6
inactive: 109.9
Methoxymalonyl-CoA: 77.3
Methylmalonyl-CoA: 61.4
Propionyl-CoA: 41.2
2-Methylbutyryl-CoA: 30.8
Ethylmalonyl-CoA: 29.8
Isobutyryl-CoA: 25.0
CHC-CoA: 23.7
Benzoyl-CoA: 17.9
trans-1,2-CPDA: 15.2
Acetyl-CoA: 11.6
fatty_acid: 10.0
3-Methylbutyryl-CoA: 0.0

melG

Search NORINE for peptide: strict or relaxed

A-OX (554..1316): X